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Tyrphostins

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Definition: A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor function.     
Pharmacological Action Antineoplastic Agents; Enzyme Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AG1801  0   *Tyrphostins Protease Inhibitors. Cell Signal. 2011 Dec;23(12):2076-85
AGL2019  0   *Tyrphostins Protease Inhibitors. Cell Signal. 2011 Dec;23(12):2076-85
WP1066  0   *Pyridines *Tyrphostins. Oncogene. 2007 Apr 12;26(17):2435-44
tyrphostin AGL-2043  0   *Tyrphostins. Cardiovasc Res 2004 Oct 1;64(1):165-71
tyrphostin AG 126  0   *Tyrphostins. Am J Physiol Gastrointest Liver Physiol 2004 Feb;286(2):G214-24
tyrphostin AG 1024  0   *Tyrphostins. Br J Cancer 2001 Dec 14;85(12):2017-21
AG 538  0   *Catechols *Tyrphostins. Biochemistry 2000 Dec 26;39(51):15705-12
6,7-dimethoxy-2-phenylquinoxaline  0   *Tyrphostins Platelet-Derived Growth Factor/antagonists & inhibitors. Arterioscler Thromb Vasc Biol 2000 Mar;20(3):667-76
tyrphostin A9  10537-47-0   *Tyrphostins. Leukemia 2000 Mar;14(3):374-8
tyrphostin 51  0   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Mol Cell Cardiol 1998 Dec;30(12):2577-90
3-methoxyl-5-(2-,2-dicyanoethenyl)catechol  0   *Catechols *Tyrphostins Nitriles Protein-Tyrosine Kinases/antagonists & inhibitors. Chung Kuo Yao Li Hsueh Pao 1997 Jan;18(1):56-8
AG 372  0   *Tyrphostins Nitriles Protein-Tyrosine Kinases/antagonists & inhibitors. Chung Kuo Yao Li Hsueh Pao 1997 Jan;18(1):56-8
tyrphostin AG 1394  0   *Tyrphostins. Chung Kuo Yao Li Hseuh Pao 1996 Jul;17(4):353-6
tyrphostin AG 1109  0   *Tyrphostins. Chung Kuo Yao Li Hseuh Pao 1996 Jul;17(4):353-6
tyrphostin AG 114  0   *Tyrphostins. Chung Kuo Yao Li Hseuh Pao 1996 Jul;17(4):353-6
tyrphostin A51  0   *Tyrphostins. Calcif Tissue Int 1998 Sep;63(3):243-9
4-nitrobenzylidene malononitrile  0   *Tyrphostins. Cancer Res 1998 Jun 1;58(11):2397-403
AG 494  139087-53-9   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. FEBS Lett 1997 Jun 30;410(2-3):187-90
6,7-dimethoxy-3-phenylquinoxaline  146535-11-7   *Tyrphostins Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Biochemistry 1997 May 27;36(21):6260-9
tyrphostin AG957  0 4-amino-N-(2,5-dihydroxybenzyl)methyl benzoate  *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Anticancer Drugs 1996 Nov;7(8):815-24
tyrphostin AG 1478  170449-18-0   *Quinazolines *Tyrphostins Receptor, Epidermal Growth Factor/antagonists & inhibitors Protein Tyrosine Phosphatases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Cancer Res 1996 Sep 1;56(17):3859-61
tyrphostin B44  0   *Tyrphostins. Experientia 1996 Jun 15;52(6):621-3
AG 556  149092-35-3   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. J Infect Dis 1996 Apr;173(4):927-33
tyrphostin AG825  0   *Tyrphostins *Benzothiazoles Protein-Tyrosine Kinases/antagonists & inhibitors. Cancer Res 1996 Mar 1;56(5):1068-74
alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide  0   *Tyrphostins. Pharmazie 1995 Aug;50(8):558-60
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide  0   *Tyrphostins.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		Blood 1995 Sep 15;86(6):2077-85
tyrphostin AG 814  0   *Tyrphostins. Exp Dermatol 1995 Apr;4(2):82-8
tyrphostin AG34  0   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Eur J Immunol 1994 May;24(5):1046-52
tyrphostin A46  118409-59-9   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Mol Cell Endocrinol 1993 Nov;97(1-2):37-49
tyrphostin AG 568  151013-48-8   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Blood 1993 Dec 15;82(12):3524-9
tyrphostin AG 1112  153150-84-6   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Blood 1993 Dec 15;82(12):3524-9
tyrphostin AG17  71308-35-5   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Br J Cancer 1993 Dec;68(6):1122-6
AG-879  0   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Biochemistry 1993 May 4;32(17):4650-8
tyrphostin 25  118409-58-8   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		Biochem Pharmacol 1993 Feb 9;45(3):711-21
tyrphostin 11  122520-73-4   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Eur J Immunol 1992 Jun;22(6):1391-6
tyrphostin 8  3785-90-8   *Tyrphostins. Eur J Immunol 1992 Jun;22(6):1391-6
RG 13022  136831-48-6 3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)  *Tyrphostins. Cancer Res 1991;51(16):4430
RG 14620  136831-49-7 3-Pyridineacetonitrile, alpha-((3,5-dichlorophenyl)methylene)  *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Cancer Res 1991;51(16):4430
AG 183  122520-90-5 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)  *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Biochem Biophys Res Commun 1991;176(3):1425
AG 127  118409-62-4   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Biochem Biophys Res Commun 1991;176(3):1425
AG 30  122520-79-0   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors. Biochem Biophys Res Commun 1991;176(3):1424
tyrphostin A23  118409-57-7   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		J Biol Chem 1989;264(24):14503
tyrphostin 47  118409-60-2   *Tyrphostins.
Pharma Action Enzyme Inhibitors 		Cell 1989;57(7):1101

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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