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Protein Isoforms

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Definition: Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.  IM general only; coordinate NIM with specific protein (IM); for enzymes use ISOENZYMES   
See Also Alternative Splicing; RNA Splice Sites
Examples Isoenzymes 		Other names Variants, Protein Splice; Isoforms, Protein; Protein Splice Variants; Splice Variants, Protein; Isoforms
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
casein kinase 2, alpha, human  EC 2.7.11.1   Casein Kinase II Protein Isoforms. Mol Cell Biochem. 2011 Oct;356(1-2):57-65
RASSF1 protein, rat  0   *Tumor Suppressor Proteins Protein Isoforms. Biomed Environ Sci. 2011 Apr;24(2):163-71
CATP-5 protein, C elegans  EC 3.6.1.-   *Adenosine Triphosphatases *Membrane Proteins *Caenorhabditis elegans Proteins Protein Isoforms. FASEB J. 2010 Jan;24(1):206-17
ssSPTa  EC 2.3.1.50   *Serine C-Palmitoyltransferase Protein Isoforms. Proc Natl Acad Sci U S A 2009 May 19;106(20):8186-91
DHRS4 protein, human  EC 1.1.1.184   *Oxidoreductases Protein Isoforms. Biosci Rep. 2009 Feb;29(1):47-56
strongylocin, Strongylocentrotus droebachiensis  0   *Antimicrobial Cationic Peptides Sea Urchins Protein Isoforms. Dev Comp Immunol 2008;32(12):1430-40
nuclear coactivator p120, human  0   *Nuclear Proteins *Transcription Factors Protein Isoforms. Endocr J 2008 Aug;55(4):657-65
COL4A3BP protein, zebrafish  EC 2.7.1.-   *Protein-Serine-Threonine Kinases *Zebrafish Proteins Protein Isoforms. J Biol Chem 2008 Jul 18;283(29):20495-504
jaburetox-2Ec, Canavalia ensiformis  EC 3.5.1.5   *Urease Protein Isoforms. Peptides 2007 Oct;28(10):2042-50
thymosin beta15, rat  0   *Thymosin Protein Isoforms. Ann N Y Acad Sci 2007 Sep;1112:286-96
periostin-like factor, rat  0   *Muscle Proteins *Cell Adhesion Molecules Protein Isoforms. Am J Physiol Cell Physiol 2007 May;292(5):C1672-80
CoAA protein, mouse  0   *Transcription Factors Protein Isoforms. Nucleic Acids Res 2007;35(6):1919-32
mechano-growth factor, rat  0   *Insulin-Like Growth Factor I Protein Isoforms. J Physiol 1999 Apr 15;516( Pt 2):583-92
clusterin-associated protein 1, human  0   *Antigens, Neoplasm Protein Isoforms. Int J Oncol 2007 Feb;30(2):461-7
DIDO1 protein, human  0   *DNA-Binding Proteins Zinc Fingers Protein Isoforms. Proc Natl Acad Sci U S A 2007 Feb 20;104(8):2691-6
CaM-KIIN protein, mouse  0   *Carrier Proteins Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors Protein Isoforms. Biochem Biophys Res Commun 2006 Nov 17;350(2):444-9
CSPP1 protein, human  0   *Microtubule-Associated Proteins *Cell Cycle Proteins Protein Isoforms. J Cell Physiol 2006 Oct;209(1):199-210
AMPD1 protein, human  EC 3.5.4.6   *AMP Deaminase Protein Isoforms. Life Sci 2006 Sep 5;79(15):1413-8
Kv1.7 potassium channel, mouse  0   *Shaker Superfamily of Potassium Channels Protein Isoforms. J Gen Physiol 2006 Jul;128(1):133-45
heat shock 70-kDa protein 8 isoform 1, human  0   *HSP70 Heat-Shock Proteins *Protein Isoforms Stem Cells. Stem Cells 2005 Nov-Dec;23(10):1502-13
schlafen-1 protein, mouse  0   *Cell Cycle Proteins Protein Isoforms. Immunity 1998 Nov;9(5):657-68
endoglin protein, mouse  0   *Intracellular Signaling Peptides and Proteins Antigens, CD Protein Isoforms. Oncogene 2005 Jun 23;24(27):4450-61
SULT1 protein, zebrafish  EC 2.8.2.1   *Arylsulfotransferase *Zebrafish Proteins Protein Isoforms. Arch Biochem Biophys 2005 May 1;437(1):10-9
ROBO3 protein, human  0   *Receptors, Immunologic Nerve Tissue Proteins Protein Isoforms.
Tsp68C protein, Drosophila  0   *Membrane Proteins *Drosophila Proteins Protein Isoforms. Oncogene 2004 Dec 2;23(56):9120-8
Scylla protein, Drosophila  0   *Drosophila Proteins Protein Isoforms. Genes Dev 2004 Dec 1;18(23):2879-92
RASSF1 protein, mouse  0   *Tumor Suppressor Proteins Protein Isoforms. Cancer Res 2005 Jan 1;65(1):92-8
Fgf8 protein, mouse  0   *Fibroblast Growth Factor 8 Protein Isoforms.
Mt2 protein, Drosophila  EC 2.1.1.-   *DNA (Cytosine-5-)-Methyltransferase *Drosophila Proteins Protein Isoforms.
Macf1 protein, mouse  0   *Microfilament Proteins Protein Isoforms.
Ctnna2 protein, mouse  0   *Nerve Tissue Proteins *alpha Catenin Protein Isoforms. Nat Genet 2002 Jul;31(3):279-84
Slitrk protein, mouse  0   *Membrane Proteins *Nerve Tissue Proteins Protein Isoforms. Mol Cell Neurosci 2003 Sep;24(1):117-29
SLC9A9 protein, human  0   *Sodium-Hydrogen Antiporter Protein Isoforms. J Med Genet 2003 Oct;40(10):733-40
NOXO1 protein, human  0   *Adaptor Proteins, Vesicular Transport Protein Isoforms. J Biol Chem 2003 Jul 4;278(27):25234-46
CTP phosphocholine cytidylyltransferase, beta isoform, mouse  EC 2.7.7.15   *Choline-Phosphate Cytidylyltransferase Protein Isoforms. Biochim Biophys Acta 2003 Jul 4;1633(1):1-12
Gle1 protein, human  0   *Nucleocytoplasmic Transport Proteins Protein Isoforms. J Cell Biol 2003 Mar 31;160(7):1029-40
SPTBN1 protein, human  0   *Spectrin Protein Isoforms. J Mol Neurosci 2001 Aug;17(1):59-70
CD44v9 antigen  0   *Antigens, CD44 Protein Isoforms. Leukemia 2002 Jan;16(1):135-43
NCX10 protein, rat  0   *Sodium-Calcium Exchanger Protein Isoforms. Calcif Tissue Int 2000 Jul;67(1):60-7
myrmexins  0   *Ant Venoms Protein Isoforms. Toxicon 2000 Oct;38(10):1403-13
metallothionein isoform 1  0   *Metallothionein Protein Isoforms. Prostate 2000 May 1;43(2):125-35
Dido protein, mouse  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers Protein Isoforms. Proc Natl Acad Sci U S A 1999 Jul 6;96(14):7992-7
ataxin-7  0   *Nerve Tissue Proteins Spinocerebellar Degenerations Protein Isoforms. Nat Genet 1997 Sep;17(1):65-70
CRMP1 protein, human  0   *Nerve Tissue Proteins Protein Isoforms. Gene 1996 Nov 21;180(1-2):157-63
Nedd4 ubiquitin protein ligases  EC 6.3.2.19   *Ubiquitin-Protein Ligases *Endosomal Sorting Complexes Required for Transport Protein Isoforms. EMBO J 1996 May 15;15(10):2371-80; Trends Biochem Sci. 2007 Dec;32(12):561-73
NFASC protein, human  0   *Nerve Growth Factors *Cell Adhesion Molecules Protein Isoforms. Cell 1987;51(5):841

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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