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Immunophilins

More information in Books or onNLM PubMed
Definition: Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.  don't confuse X ref NEUROPHILINS with NEUROPILINS   
Examples Cyclophilins; Tacrolimus Binding Proteins 		Other names Neurophilins; Neurophilin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
FKB-6 protein, C elegans  EC 5.2.1.8   *Immunophilins *Caenorhabditis elegans Proteins. Biochem Biophys Res Commun 2007 Aug 31;360(3):566-72
FPR3 protein, S cerevisiae  EC 5.2.1.-   *Immunophilins *Saccharomyces cerevisiae Proteins.
FKBPL protein, human  0   *Immunophilins. Radiat Res 1999 Nov;152(5):451-61
TLP40 protein, plant  EC 5.2.1.-   *Plant Proteins *Immunophilins. EMBO J 1998 Mar 16;17(6):1577-87

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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