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Sirolimus

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Definition: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.     
Pharmacological Action Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Immunosuppressive Agents 		Other names I2190A; I 2190A; AY 22989; AY 22 989; Wyeth Brand of Sirolimus; Rapamune; I-2190A; AY 22-989; RapamycinDrugs* : RAPAMUNE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
homotemsirolimuse C  0   Sirolimus/*analogs & derivatives. J Nat Prod. 2011 Apr 25;74(4):547-53
homotemsirolimuse B  0   Sirolimus/*analogs & derivatives. J Nat Prod. 2011 Apr 25;74(4):547-53
homotemsirolimuse A  0   Sirolimus/*analogs & derivatives. J Nat Prod. 2011 Apr 25;74(4):547-53
AP 21967  0   Sirolimus/*analogs & derivatives. Nucleic Acids Res 2009 Mar;37(4):e30
Biolimus A9  0   Sirolimus/*analogs & derivatives. Expert Rev Med Devices 2006 Nov;3(6):731-41
ridaforolimus  0   Sirolimus/*analogs & derivatives. IDrugs 2006 Sep;9(9):636-44
SDZ RAD 223-756  0   Sirolimus/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 2002 Jun 5;772(2):283-90
15-deoxo-7,32-O-didesmethylrapamycin  0   Sirolimus/*analogs & derivatives. J Antibiot (Tokyo) 2004 Jul;57(7):415-20462-4
zotarolimus  0   Sirolimus/*analogs & derivatives. Herz 2004 Mar;29(2):167-70
pre-rapamycin  0   Sirolimus/*analogs & derivatives. Angew Chem Int Ed Engl 2004 May 3;43(19):2551-3
SAR943  0   Sirolimus/*analogs & derivatives. Immunology. 2003 Jul;109(3):461-7
temsirolimus  0   Sirolimus/*analogs & derivatives Antineoplastic Agents Protein Kinase Inhibitors. Bull Cancer 1999 Oct;86(10):808-11TORISEL
rapamycin tris-epoxide metabolite  0   Sirolimus/*analogs & derivatives. J Mass Spectrom 1999 Jan;34(1):28-32
everolimus  159351-69-6   Sirolimus/*analogs & derivatives.
Pharma Action Immunosuppressive Agents 		Transplantation 1997 Jul 15;64(1):36-42AFINITOR; ZORTRESS
rapamycin-28-N,N-dimethylglycinate  0   Sirolimus/*analogs & derivatives. Cancer Chemother Pharmacol 1994;33(4):325-30
WAY 124466  149438-31-3   Sirolimus/*analogs & derivatives. Biochem Biophys Res Commun 1993 May 14;192(3):1340-6
demethoxyrapamycin  83482-58-0   Sirolimus/*analogs & derivatives. J Antibiot (Tokyo) 1983;36(4):351

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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