encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 

P-Glycoprotein

More information in Books or onNLM PubMed
Definition: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).  P-GLYCOPROTEINS is also available   
See Also Drug Resistance, Multiple 		Other names PGY 1 Protein; P Glycoprotein; PGY-1 Protein; ATP-Binding Cassette, Sub-Family B, Member 1; P-gp; Multidrug Resistance Protein 1; MDR1 Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
rivulobirin A  0   *Psoralens P-Glycoprotein/antagonists & inhibitors. Zhongguo Zhong Yao Za Zhi. 2006 Feb;31(4):309-11.
BPR-DC-2 compound  0   *Guanidines P-Glycoprotein/antagonists & inhibitors. Invest New Drugs. 2011 Apr;29(2):195-206
Syl611 compound  0   *Taxoids P-Glycoprotein/antagonists & inhibitors. Cancer Chemother Pharmacol 2010 Oct;66(5):851-9
cyclic-tris-(R)-valineselenazole  0   *Peptides, Cyclic Stereoisomerism P-Glycoprotein/antagonists & inhibitors. Science 2009 Mar 27;323(5922):1718-22
4-oxo-4H-chromene-2-carboxylic acid (2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl)-phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)amide  0   *Benzopyrans *Isoquinolines *Tetrazoles P-Glycoprotein/antagonists & inhibitors. Rapid Commun Mass Spectrom. 2006;20(9):1457-62
4-chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide  0   *Benzamides Guaiacol/*analogs & derivatives P-Glycoprotein/antagonists & inhibitors. Biochem Biophys Res Commun 2007 Mar 30;355(1):136-42
ABCB1 protein, human  0   *P-Glycoprotein. Br J Clin Pharmacol. 2006 Apr;61(4):440-50
Abcb1b protein, mouse  EC 3.6.3.44   *P-Glycoprotein. Biol Reprod 2005 Oct;73(4):591-7
N-1-benzyl-2,3-dihydro-1H-pyrrolo(2,3-b)quinolin-4-yl-2-phenylacetamide  0   *Acetanilides *Pyrroles *Quinolines P-Glycoprotein/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1413-22
ABCB5 protein, human  0   *P-Glycoprotein. J Biol Chem 2003 Nov 21;278(47):47156-65
EhPgp5 protein, Entamoeba histolytica  0   *Protozoan Proteins *P-Glycoprotein. Gene 1995 Oct 16;164(1):179-84
tt12 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins P-Glycoprotein. Plant Cell 2001 Apr;13(4):853-71
SB T-101187  0   Taxoids P-Glycoprotein/antagonists & inhibitors. Br J Cancer 2000 Dec;83(12):1762-8
SB T-1250  0   *Taxoids P-Glycoprotein/antagonists & inhibitors. Br J Cancer 2000 Dec;83(12):1762-8
R 101933  0   *Benzazepines *Quinolines Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Clin Cancer Res 2000 Apr;6(4):1365-71
CP 147673  0   *Piperazines Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Biochemistry 2000 Jan 11;39(1):75-85
CP 172732  0   *Piperazines *Thiazoles Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Biochemistry 2000 Jan 11;39(1):75-85
CP 162398  0   *Piperazines *Quinolines Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Biochemistry 2000 Jan 11;39(1):75-85
AHC 93  0   *Pyrazoles *Pyridines P-Glycoprotein/antagonists & inhibitors. Exp Cell Res 1999 Dec 15;253(2):396-402
GF 120918  143664-11-3   *Acridines *Tetrahydroisoquinolines Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Cancer Res 1993 Oct 1;53(19):4595-602
valspodar  121584-18-7   *Cyclosporins Drug Resistance, Multiple P-Glycoprotein. Cancer Res 1991;51(16):4226

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy