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Caspase 1

More information in Books or onNLM PubMed
Definition: A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.     
See Also Apoptosis; Interleukin-1 		Other names beta-Converting Enzyme, IL-1; beta Convertase, IL-1; Procaspase 1; Pro Caspase 1; Interleukin 1beta Converting Enzyme; Interleukin 1 Converting Enzyme; IL 1 beta Converting Enzyme; IL 1 beta Convertase; Converting Enzyme, Interleukin-1beta; Converting Enzyme, Interleukin-1; Convertase, IL-1 beta; Caspase, CASP1; Procaspase-1; Pro-Caspase-1; Interleukin-1 Converting Enzyme; IL1BC Enzyme; IL-1 beta Convertase; CASP1 Caspase; Interleukin-1beta Converting Enzyme; IL-1 beta-Converting Enzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CM 269  0   *Bicyclo Compounds, Heterocyclic Aspartic Acid/*analogs & derivatives Caspase 1/antagonists & inhibitors. Chem Biol 2010 Sep 24;17(9):999-1007
VRT 018858  0   *Azepines *Isoquinolines Caspase 1/antagonists & inhibitors. Neuropharmacology 2007 Oct;53(5):638-42
1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid  0   *Dipeptides 4-Aminobenzoic Acid/*analogs & derivatives Caspase 1/antagonists & inhibitors. J Pharmacol Exp Ther 2007 May;321(2):509-16
NLRP10 protein, human  0   *Carrier Proteins Caspase 1/antagonists & inhibitors. Int Immunol 2004 Jun;16(6):777-86
EI 2128-1  0   *Epoxy Compounds *Spiro Compounds Caspase 1/antagonists & inhibitors. J Antibiot (Tokyo) 2003 Nov;56(11):891-8
diphenyl ether sulfonamide  0   *Ethers *Sulfonamides Caspase 1. Bioorg Med Chem Lett 2001 Oct 22;11(20):2779-82
N1445  0   *Cytochalasins Caspase 1/antagonists & inhibitors. Cancer J Sci Am 1999 Sep-Oct;5(5):293-300
PD 194035  0   *Azepines *Oxaloacetates Caspase 1/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jun 7;9(11):1587-92

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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