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Lymphoma, Mantle-Cell

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Definition: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).     
See Also Cyclin D1; Genes, bcl-1 		Other names Small-Cell Lymphomas, Centrocytic; Small-Cell Lymphoma, Centrocytic; Mantle-Zone Lymphomas; Mantle-Cell Lymphomas; Mantle Zone Lymphoma; Mantle Cell Lymphoma; Lymphomas, Mantle-Zone; Lymphomas, Mantle-Cell; Lymphomas, Centrocytic Small-Cell; Lymphoma, Mantle-Zone; Lymphoma, Mantle Cell; Lymphoma, Centrocytic Small Cell; Diffuse Lymphocytic Lymphoma, Poorly Differentiate; Centrocytic Small-Cell Lymphomas; Centrocytic Small-Cell Lymphoma; Lymphocytic Lymphoma, Diffuse, Poorly Differentiat; Diffuse Lymphocytic Lymphoma, Poorly-Differentiate; Mantle-Zone Lymphoma; Mantle-Cell Lymphoma; Lymphoma, Small-Cell, Centrocytic

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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