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Guanine Nucleotide Exchange Factors

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Definition: Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.     
Examples Eukaryotic Initiation Factor-2B; Guanine Nucleotide-Releasing Factor 2; Proto-Oncogene Proteins c-vav; ral Guanine Nucleotide Exchange Factor; ras Guanine Nucleotide Exchange Factors 		Other names Reversing Factors, GDP-GTP; Guanine Nucleotide Releasing Factor; GDP GTP Reversing Factors; GDP GTP Exchange Protein; Factors, GDP-GTP Reversing; Factors, GDP Exchange; Exchange Factors, GDP; Guanine-Nucleotide-Releasing Factor; Guanine Nucleotide Exchange Factor; GDP-GTP Exchange Protein; GDP Dissociation Stimulators; GDP Dissociation Factor; Guanine Nucleotide Releasing Factors; GDP-GTP Reversing Factors; GDP Exchange Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
FGD5 protein, human  0   *Guanine Nucleotide Exchange Factors. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):988-96.
connecdenn 3 protein, human  0   *Microfilament Proteins *Guanine Nucleotide Exchange Factors. Mol Biol Cell. 2012 Jan;23(1):163-75.
Swap70 protein, zebrafish  0   *Nuclear Proteins *Guanine Nucleotide Exchange Factors *Zebrafish Proteins. Mol Cell Neurosci. 2011 Nov;48(3):225-35
Ric-8A protein, human  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2011 Sep 2;286(35):31055-61
DOCK10 protein, mouse  0   *Guanine Nucleotide Exchange Factors. Hum Immunol. 2011 Jul;72(7):531-7
Dbl protein, rat  0   *Guanine Nucleotide Exchange Factors. Am J Physiol Gastrointest Liver Physiol 2011 Jun;300(6):G988-97
Ric8b protein, mouse  0   *Guanine Nucleotide Exchange Factors.
Dennd4C protein, mouse  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2011 May 13;286(19):16541-5
Dennd4C protein, human  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2011 May 13;286(19):16541-5
LARG protein, Xenopus  0   *Guanine Nucleotide Exchange Factors *Xenopus Proteins. Biofizika. 2010 Nov-Dec;55(6): 1002-7
Arfgef2 protein, mouse  0   *Guanine Nucleotide Exchange Factors. Int J Dev Biol. 2010;54(8-9):1259-66
Vps9a protein, Arabidopsis  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2010 Nov 19;285(47):36689-97
ARHGEF16 protein, human  0   *Guanine Nucleotide Exchange Factors. Br J Cancer 2011 Jan 18;104(2):324-31
RopGEF1 protein, Arabidopsis  0   *Guanine Nucleotide Exchange Factors *Arabidopsis Proteins. J Biol Chem 2010 Oct 15;285(42):32151-9
Rabex-5 protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Protein Ligases Guanine Nucleotide Exchange Factors. Curr Biol 2010 aug 10;20(15):1378-82
Ric1 protein, S pombe  0   *Guanine Nucleotide Exchange Factors *Schizosaccharomyces pombe Proteins. Mol Genet Genomics 2010 Sep;284(3):161-71
p190RhoGEF protein, human  0   *Guanine Nucleotide Exchange Factors. Amyotroph Lateral Scler 2010;11(1-2):97-103
IQSEC2 protein, human  0   *Guanine Nucleotide Exchange Factors. Nat Genet 2010 Jun;42(6):486-8
VPS39 protein, mouse  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2010 May 28;285(22):16814-21
Lfc protein, rat  0   *Guanine Nucleotide Exchange Factors. J Neurosci 2010 May 12;30(19):6793-800
FGD3 protein, human  0   *Guanine Nucleotide Exchange Factors. Genes Cells 2008 Apr;13(4):329-42
RalGPS2 protein, rat  0   *Guanine Nucleotide Exchange Factors. Neurosci Res. 2010 Mar;66(3):290-8
kalirin protein, mouse  0   *Guanine Nucleotide Exchange Factors. Mol Cell Neurosci 2010 Jan;43(1):81-9
CGEF-1 protein, C elegans  0   *Guanine Nucleotide Exchange Factors *Caenorhabditis elegans Proteins. Mol Biol Cell 2010 Jan;21(2):266-77
Asef2 protein, mouse  0   *Guanine Nucleotide Exchange Factors. EMBO Rep 2009 Dec;10(12):1355-62
Asef protein, mouse  0   *Guanine Nucleotide Exchange Factors. EMBO Rep 2009 Dec;10(12):1355-62
RanBP10 protein, mouse  0   *Microtubule-Associated Proteins *Guanine Nucleotide Exchange Factors. Blood 2009 Dec 24;114(27):5532-40
DENND1B protein, human  0   *Guanine Nucleotide Exchange Factors *Death Domain Receptor Signaling Adaptor Proteins. N Engl J Med. 2010 Jan 7;362(1):36-44
Varp protein, rat  0   *Guanine Nucleotide Exchange Factors Ankyrin Repeat.
Dock8 protein, mouse  0   *Guanine Nucleotide Exchange Factors. Nat Immunol 2009 Dec;10(12):1283-91
ARHGEF5 protein, mouse  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2009 Oct 16;284(42):28599-606
Epac protein, Drosophila  0   *Guanine Nucleotide Exchange Factors *Drosophila Proteins. Mol Cell Endocrinol. 2009 Jun 16;305(1-2); 30-7
zizimin1 protein, mouse  0   *Guanine Nucleotide Exchange Factors. J Neurosci Res 2009 Jun;87(8):1794-805
BRAG1 protein, mouse  0   *Nerve Tissue Proteins *Guanine Nucleotide Exchange Factors. Brain Res 2009 Jan 28;1251:7-15
SidM protein, Legionella pneumophila  0   *Bacterial Proteins *Guanine Nucleotide Exchange Factors. J Biol Chem 2009 Feb 20;284(8):4846-56
Dock7 protein, mouse  0   *Guanine Nucleotide Exchange Factors. Proc Natl Acad Sci U S A 2009 Feb 24;106(8):2706-11
ephexin protein, Drosophila  0   *Guanine Nucleotide Exchange Factors *Drosophila Proteins. Neuron 2009 Feb 26;61(4):556-69
Sec12 protein, Drosophila  0   *Guanine Nucleotide Exchange Factors *Drosophila Proteins. Mol Biol Cell 2008 Oct;19(10):4352-65
P-Rex1 protein, rat  0   *Guanine Nucleotide Exchange Factors. J Cell Sci 2008 Sep 1;121(Pt 17):2892-903
syx protein, zebrafish  0   *Guanine Nucleotide Exchange Factors *Zebrafish Proteins. Circ Res 2008 Sep 26;103(7):710-6
Epac-2 protein, rat  0   *Guanine Nucleotide Exchange Factors. J Physiol 2001 Oct 15;536(Pt 2):375-85
Dock5 protein, mouse  0   *Guanine Nucleotide Exchange Factors. Exp Eye Res 2008 May;86(5):828-34
Als2 protein, rat  0   *Guanine Nucleotide Exchange Factors. Neurobiol Dis 2005 Mar;18(2):243-57
Dock10 protein, human  0   *Guanine Nucleotide Exchange Factors. Mol Immunol 2008 Jul;45(12):3411-8
GEFT protein, mouse  0   *Guanine Nucleotide Exchange Factors. Proc Natl Acad Sci U S A 2008 Jun 17;105(24):8298-303
RANBP10 protein, human  0   *Microtubule-Associated Proteins *Guanine Nucleotide Exchange Factors. J Biol Chem 2008 May 16;283(20):14109-19
Varp protein, human  0   *Guanine Nucleotide Exchange Factors Ankyrin Repeat. Biochem Biophys Res Commun 2008 Jul 18;372(1):162-7
Gapex-5 protein, mouse  0   *Guanine Nucleotide Exchange Factors. Nature 2008 May 8;453(7192):241-5
Get3 protein, S cerevisiae  EC 3.6.3.16   *Adenosine Triphosphatases *Guanine Nucleotide Exchange Factors *Saccharomyces cerevisiae Proteins. Biometals 2003 Sep;16(3):369-78
Dock180 protein, mouse  0   *Guanine Nucleotide Exchange Factors. J Cell Biol 2008 Mar 10;180(5):1005-19
PLEKHG2 protein, human  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2008 Jan 25;283(4):1946-53
PLEKHG6 protein, human  0   *Guanine Nucleotide Exchange Factors. Mol Biol Cell 2007 Dec;18(12):4780-93
Epac-1 protein, rat  0   *Guanine Nucleotide Exchange Factors. Exp Cell Res 2008 Jan 15;314(2):255-63
Akap13 protein, mouse  0   *Guanine Nucleotide Exchange Factors *A Kinase Anchor Proteins. J Biol Chem 2007 Nov 30;282(48):35308-17
Ric-8 protein, Xenopus  0   *Guanine Nucleotide Exchange Factors *Xenopus Proteins. J Cell Physiol 2008 Mar;214(3):673-80
SPATA13 protein, human  0   *Guanine Nucleotide Exchange Factors. Oncogene 2007 Dec 6;26(55):7620-267
RopGEF12 protein, Arabidopsis  0   *Guanine Nucleotide Exchange Factors *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2007 Nov 20;104(47):18830-5
KIAA1110 protein, human  0   *Guanine Nucleotide Exchange Factors. Biochem Biophys Res Commun 2007 Dec 28;364(4):737-42
ephexin protein, human  0   *Guanine Nucleotide Exchange Factors. J Biol Chem 2007 Oct 19;282(42):31103-12
PDZ-RhoGEF, rat  0   *Guanine Nucleotide Exchange Factors. J Hypertens 2007 Aug;25(8):1687-97
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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