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Glucuronides

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Definition: Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.     
See Also Uridine Diphosphate Glucuronic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-chloro-4-methylumbelliferyl-beta-D-glucuronide  0   *Glucuronides. Plant Physiol. 2011 Oct;157(2):563-73
darexaban glucuronide  0   *Azepines *Benzamides *Glucuronides. Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55
7-methoxybaicalein 6-O-glucuronide  0   *Glucuronides *Flavanones. J Asian Nat Prod Res. 2011 Sep;13(9):861-8
5-O-feruloylquinic acid 4'-O-glucuronide  0   *Glucuronides Quinic Acid/*analogs & derivatives. J Agric Food Chem. 2011 May 25;59(10):5671-6
keshonin  0   *Glucuronides *Flavones Lipase/antagonists & inhibitors. Phytochemistry. 2010 Nov;71(16):1884-91
chrysoeriol 7-O-beta-D-glucopyranosiduronic acid-(1-2)-beta-D-glucopyranoside  0   *Flavonoids *Glucuronides. J Nat Prod. 2009 May 22;72(5):835-40
luteolin 7-O-beta-D-glucopyranosiduronic acid-(1-2)-beta-D-glucopyranoside  0   *Flavonoids *Glucuronides. J Nat Prod. 2009 May 22;72(5):835-40
vabicaserin carbamoyl glucuronide  0   *Azepines *Glucuronides. Drugs Metab Dispos 2010 Apr;38(4):581-90
1,2-dihydro-2-amino-5-O-glucuronide-3-methylimidazo(4,5-f)quinoline  0   *Hydroxyquinolines *Glucuronides. J Mass Spectrom 2009 Sep;44(9):1359-68
4-hydroxy-3-methoxymethamphetamine glucuronide  0   *Glucuronides Methamphetamine/*analogs & derivatives. Chem Pharm Bull (Tokyo). 2009 May;57(5):472-5
achyranthoside H  0   *Saponins *Glucuronides. Nat Med (Tokyo) 2008 Jan;62(1):57-62
achyranthoside G  0   *Saponins *Glucuronides. Nat Med (Tokyo) 2008 Jan;62(1):57-62
epicatechin-glucuronide  0   *Glucuronides Catechin/*analogs & derivatives. Free Radic Res 2007 Aug;41(8):943-9
1-bromo-2-propanol-glucuronide  0   *Glucuronides. Biol Reprod 2007 Mar;76(3):496-505
technetium 99m exorphin C glucuronide  0   *Organotechnetium Compounds *Glucuronides. Appl Radiat Isot 2007 Feb;65(2):170-5
N,N-diethylglycolamide-4',5,6-trihydroxyflavone-7-glucuronide ester  0   *Glucuronides *Flavones. Eur J Pharm Sci 2006 Dec;29(5):385-93
ethyl scutellarin  0   *Glucuronides *Flavones. Eur J Pharm Sci 2006 Dec;29(5):385-93
benzyl scutellarin  0   *Glucuronides *Flavones. Eur J Pharm Sci 2006 Dec;29(5):385-93
imipramine N-glucuronide  0   *Glucuronides Imipramine/*analogs & derivatives. Acta Pharmacol Sin 2006 May;27(5):623-8
bisphenol A glucuronide  0   *Phenols *Glucuronides. Toxicol Appl Pharmacol 2000 Nov 1;168(3):225-34
ezetimibe glucuronide  0   *Azetidines *Glucuronides. Clin Ther. 2006 Mar;28(3):373-87
varenicline N-carbamoylglucuronide  0   *Benzazepines *Glucuronides. Drug Metab Dispos. 2006 Jan;34(1):121-30
4-aminobiphenyl-N-glucuronide  0   *Biphenyl Compounds *Glucuronides. Anal Biochem 2005 May 15;340(2):352-8
2-hydroxyestradiol-17-glucuronide  0   *Glucuronides Estradiol/*analogs & derivatives. Drug Metab Dispos 2005 Mar;33(3):466-73
5-hydroxytryptophol glucuronide  0   *Glucuronides Hydroxytryptophol/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):107-12
resveratrol-4'-O-glucuronide  0   *Stilbenes *Glucuronides. J Pharm Sci. 2004 Oct;93(10):2448-57
leukotriene B4 glucuronide  0   *Glucuronides Leukotriene B4/*analogs & derivatives. Clin Exp Allergy 2004 Aug;34(8):1262-9
18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide  0   *Glucuronides Glycyrrhetinic Acid/*analogs & derivatives. Arch Pharm Res. 2004 Jan;27(1):5760
peonidin 3-glucuronide  0   *Anthocyanins *Glucuronides. J Nutr 2004 Sep;134(9):2275-9
oxymorphone-3-glucuronide  0   *Glucuronides Oxymorphone/*analogs & derivatives. Pharmacotherapy 2004 Apr;24(4):468-76
1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid  0   *Glucuronides Diclofenac/*analogs & derivatives. J Med Chem 2004 May 20;47(11):2816-25
HMR 1098 glucuronide  0   *Sulfonamides *Glucuronides. Drug Metab Dispos 2003 Aug;31(8):1027-34
mexiletine carbonyloxy glucuronide  0   *Glucuronides Mexiletine/*analogs & derivatives. Xenobiotica 2003 Aug;33(8):871-84
4-cresylglucuronide  0   *Cresols *Glucuronides. Kidney Int 2003 Oct;64(4):1365-73
1-O-(2,4-dimethyl-3-(2-methyl-2-(3,4-dimethoxyphenylethylamino)ethoxy)phenyl)glucuronic acid  0   *Glucuronides. Yao Xue Xue Bao 2001 Jun;36(6):440-3
1-O-(24-deoxycholyl)-2-deoxyglucopyranuronic acid  0   *Glucuronides Deoxycholic Acid/*analogs & derivatives. Lipids 2003 Aug;38(8):873-9
1-O-clofibryl glucuronide  0   *Glucuronides Clofibric Acid/*analogs & derivatives. Chem Biol Interact. 2003 May 6;145(2):201-11
luteolin-7-glucuronide ethyl ester  0   *Glucuronides *Luteolin. Clin Chim Acta 2002 Feb;316(1-2):95-9
luteolin-7-glucuronide methyl ester  0   *Glucuronides *Luteolin. Clin Chim Acta 2002 Feb;316(1-2):95-9
2-amino-5-nitro-4-trifluoromethylphenol glucuronide  0   *Glucuronides. Eur J Clin Pharmacol 2002 Apr;58(1):11-4
wogonin-7-glucuronide  0   *Glucuronides *Flavanones. J Chromatogr B Analyt Technol Biomed Life Sci 2002 Aug 5;775(2):169-78
9-aminocamptothecin glucuronide  0   *Glucuronides Camptothecin/*analogs & derivatives. Br J Cancer 2002 May 20;86(10):1634-8
7-ethyl-10-hydroxycamptothecin glucuronide  0   *Glucuronides Camptothecin/*analogs & derivatives. Biochem Biophys Res Commun 2001 Nov 9;288(4):827-32
naproxen glucuronide  0   *Glucuronides Naproxen/*analogs & derivatives. Blood 2001 Jun 15;97(12):3846-50
N'-3-oxymethylglucuronide phenytoin  0   *Glucuronides Phenytoin/*analogs & derivatives. Clin Chem 2001 May;47(5):910-8
phenylthioglucuronide  0   *Glucuronides. Fresenius J Anal Chem 2001 Feb;369(3-4):273-9
dihydroartemisinin beta-glucuronide  0   *Glucuronides *Artemisinins. J Med Chem 2001 Apr 26;44(9):1467-70
glutarylpaclitaxel 6-aminohexanol glucuronide  0   *Taxoids *Glucuronides. Int J Oncol 1998 Feb;12(2) :391-4
4-trifluoromethylumbelliferylglucuronide  0   *Glucuronides Hymecromone/*analogs & derivatives. J Microbiol Methods 2000 Nov;42(3):233-44
apigenin-7-methylglucuronide  0   *Glucuronides *Apigenin. Ceska Slov Farm 2000 Mar;49(2):75-7
mycophenolic acid glucuronide  0   *Glucuronides Mycophenolic Acid/*analogs & derivatives. Int J Clin Pharmacol Ther 1998 Mar;36(3):159-63

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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