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Calcium Channels, L-Type

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Definition: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.  DF: VDCC L    Other names VDCC, L-Type; Receptor, Dihydropyridine; Long Lasting Calcium Channels; L Type Voltage Dependent Calcium Channels; L Type VDCC gamma Subunit; L Type VDCC delta Subunit; L Type VDCC beta Subunit; L Type VDCC alpha 2 Subunit; L Type VDCC alpha 1 Subunit; L Type VDCC; L Type Calcium Channels; L Type Calcium Channel; Calcium Channels, Long-Lasting; Calcium Channels, L Type; L-Type Voltage-Dependent Calcium Channels; L-Type VDCC gamma Subunit; L-Type VDCC delta Subunit; Calcium Channel, L-Type; L-Type VDCC beta Subunit; L-Type VDCC alpha-2 Subunit
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-((4-chlorophenyl)sulfonyl)-2-(2-thienyl)pyrrolidine  0   *Pyrrolidines *Sulfonamides Calcium Channels, L-Type. J Med Chem 2009 Nov 12;52(21):6637-48
Ca(v)1.1 protein, mouse  0   *Calcium Channels, L-Type Muscle Proteins. Pflugers Arch 2008 Feb;455(5):873-84
Cav1.2 protein, mouse  0   *Calcium Channels, L-Type Protein Subunits. J Mol Cell Cardiol 2006 Jul;41(1):115-25
calcium channel, voltage-dependent, alpha 2/delta subunit 4 protein, mouse  0   *Calcium Channels, L-Type. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3523-30
CACNB1 protein, zebrafish  0   *Calcium Channels, L-Type *Zebrafish Proteins. Cell Calcium. 2006 Mar;39(3):227-36
alpha1D (Cav1.3) L-type calcium channel, human  0   *Calcium Channels, L-Type. Circulation. 2005 Jun 14;111(23):3034-41
Cacna1c protein, rat  0   *Calcium Channels, L-Type. J Biol Chem 1990 Oct 15;265(29):17786-91
CACNA2D4 protein, human  0   *Calcium Channels, L-Type.
calcium channel, l type beta2c subunit, rat  0   *Calcium Channels, L-Type. Eur J Pharmacol. 2004 Mar 8;487(1-3):37-45
Cacnb1 protein, mouse  0   *Calcium Channels, L-Type. J Mol Neurosci 2003;21(1):13-21
Cacnb2 protein, mouse  0   *Calcium Channels, L-Type.
Cacnb2 protein, rat  0   *Calcium Channels, L-Type.
Cav1.3a protein, zebrafish  0   *Calcium Channels, L-Type. J Neurosci 2004 Apr 28;24(17):4213-23
Cacna1d protein, mouse  0   *Calcium Channels, L-Type. J Biol Chem 2003 Oct 17;278(42):40837-41
dihydropyridine receptor (671-690)  0   *Peptide Fragments *Calcium Channels, L-Type. Biochem J 2004 Jan 15;377(Pt 2):385-94
CACNA1D protein, human  0   *Calcium Channels, L-Type. Mol Neurobiol 2002 Aug;26(1):21-44
L-type calcium channel alpha(1C)  0   *Calcium Channels, L-Type. J Biol Chem 2000 Dec 15;275(50):39193-9
CACNA1F protein, human  0   *Calcium Channels, L-Type Night Blindness. Nat Genet 1998 Jul;19(3):260-3
CACNB2 protein, human  0   *Calcium Channels, L-Type. Hum Genet 1997 Aug;100(2):151-4
CACNA1C protein, human  0   *Calcium Channels, L-Type. Genomics 1992 Dec;14(4):1092-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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