Definition: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
DF: VDCC L
Other names VDCC, L-Type; Receptor, Dihydropyridine; Long Lasting Calcium Channels; L Type Voltage Dependent Calcium Channels; L Type VDCC gamma Subunit; L Type VDCC delta Subunit; L Type VDCC beta Subunit; L Type VDCC alpha 2 Subunit; L Type VDCC alpha 1 Subunit; L Type VDCC; L Type Calcium Channels; L Type Calcium Channel; Calcium Channels, Long-Lasting; Calcium Channels, L Type; L-Type Voltage-Dependent Calcium Channels; L-Type VDCC gamma Subunit; L-Type VDCC delta Subunit; Calcium Channel, L-Type; L-Type VDCC beta Subunit; L-Type VDCC alpha-2 Subunit