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Matrix Metalloproteinase 1

More information in Books or onNLM PubMed
Definition: A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.  /antag is permitted but TISSUE INHIBITOR OF METALLOPROTEINASE-1 is available    Other names proMMP 1; Promatrixmetalloproteinase 1; Pro Matrix Metalloproteinase 1; Metalloproteinase-1, Pro-Matrix; Metalloproteinase, MMP1; Metalloproteinase, MMP-1; Metalloproteinase 1, Matrix; MMP 1 Metalloproteinase; proMMP-1; Promatrixmetalloproteinase-1; Pro-Matrix Metalloproteinase-1; Matrix Metalloproteinase-1; MMP1 Metalloproteinase; MMP-1 Metalloproteinase; Interstitial Collagenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-methoxybenzyl)-1H-indol-3-yl)propanoic acid  0   *Sulfonamides Tryptophan/*analogs & derivatives Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 13/antagonists & inhibitors Matrix Metalloproteinase 14/antagonists & inhibitors. Bioorg Med Chem 2009 Jun 1;17(11):3857-65
MMP1 protein, human  EC 3.4.24.7   *Matrix Metalloproteinase 1.
N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide  0   *Hydroxamic Acids *Sulfonamides Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors. Bioorg Med Chem 2006 Jun 15;14(12):4260-76
N-hydroxy-4-((4-(phenylthio)phenyl)sulfonyl)-1-(2-propynyl)-4-piperidinecarboxamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinase 1/antagonists & inhibitors. J Med Chem 2005 Oct 20;48(21):6713-30
Mmp1b protein, mouse  EC 3.4.25.-   *Matrix Metalloproteinase 1. J Biol Chem 2001 Mar 30;276(13):10253-62
Mmp1a protein, mouse  EC 3.4.24.-   *Matrix Metalloproteinase 1. J Biol Chem 2001 Mar 30;276(13):10253-62
YLL 224  0   *Imines *Indoles Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 7/antagonists & inhibitors Matrix Metalloproteinase 8/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Aug 11;274(3):780-6
MAG 283  0   *Amides *Sulfhydryl Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 7/antagonists & inhibitors Matrix Metalloproteinase 8/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Aug 11;274(3):780-6
funalenone  0   *Ketones *Polycyclic Compounds Matrix Metalloproteinase 1/antagonists & inhibitors. J Antibiot (Tokyo) 1999 Dec;52(12):1095-100

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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