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Matrix Metalloproteinases

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Definition: A family of zinc-dependent metalloendopeptidases that are involved in the degradation of EXTRACELLULAR MATRIX components. EC 3.4.24.-.  /antag is permitted but TISSUE INHIBITOR OF METALLOPROTEINASES is available; check MeSH for specific matrix metalloproteinases   
Examples Matrix Metalloproteinases, Membrane-Associated; Matrix Metalloproteinases, Secreted 		Other names MMPs
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Rv0198c protein, Mycobacterium tuberculosis  EC 3.4.24.-   *Bacterial Proteins *Matrix Metalloproteinases. Tuberculosis (Edinb). 2011 Mar;91(2):111-6
ZMP-2 protein, C elegans  EC 3.4.24.-   *Matrix Metalloproteinases *Caenorhabditis elegans Proteins. Dev Comp Immunol 2010 Nov;34(11):1160-9
MMP23b protein, zebrafish  EC 3.4.24.-   *Matrix Metalloproteinases *Zebrafish Proteins. Hepatology 2010 Dec;52(6):2158-66
1-cyclopropyl-N-hydroxy-4-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)piperidine-4-carboxamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6653-80
N-hydroxy-1-(2-methoxyethyl)-4-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)piperidine-4-carboxamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6653-80
N-hydroxy-4-((4-(4-(trifluoromethyl)phenoxy)phenyl)sulfonyl)tetrahydro-2H-pyran-4-carboxamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6653-80
2-aminocyclohexylcarbamoylphosphonic acid  0   *Phosphonic Acids Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1406-14
triazin 17-2  0   *Sulfones *Triazines Matrix Metalloproteinases/antagonists & inhibitors. Int J Oncol 2008 Jan;32(1):273-82
RXP 409  0   *Phosphinic Acids Tryptophan/*analogs & derivatives Matrix Metalloproteinases/antagonists & inhibitors. Hepatalogy 2008 Jan;47(1):177-85
MMP-28 protein, Xenopus  EC 3.4.24.-   *Matrix Metalloproteinases *Xenopus Proteins. Dev Dyn 2007 Oct;236(10):2852-64
S 3304  0   *Indoles *Thiophenes Matrix Metalloproteinases/antagonists & inhibitors. Int J Clin Pharmacol Ther 2005 Jun;43(6):282-93
6-(4-(4-imidazol-1-ylphenoxy)benzenesulfonyl)-4,5,6,7-tetrahydrofuro(2,3-c)pyridine-5-carboxylic acid  0   *Pyridines *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. Arthritis Rheum 2005 Jan;52(1):171-80
N-hydroxy-2-(((4'-methoxyphenyl)sulfonyl)benzylamino)-3-methylbutanamide  0   *Hydroxamic Acids *Sulfonamides Carbon Radioisotopes Matrix Metalloproteinases/antagonists & inhibitors. Nucl Med Biol 2004 Jan;31(1):77-85
2-(4'-methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid  0   *Sulfonamides Valine/*analogs & derivatives Carbon Radioisotopes Matrix Metalloproteinases/antagonists & inhibitors. Nucl Med Biol 2004 Jan;31(1):77-85
2-(4-hydroxy-3-methyl-2-butenyl)hydroquinone  0   *Hydroquinones Matrix Metalloproteinases/antagonists & inhibitors. Biosci Biotechnol Biochem 2002 Dec;66(12):2748-50
1-benzyl-4-(4-(4-chlorophenoxy)benzenesulfonyl)piperidine-4-carboxylic acid  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2003 Jun 5;46(12):2376-96
N-hydroxy-2-(4-methoxybenzenesulfonyl)-2-methyl-3-(4-(2-piperidin-1-ylethoxy)phenyl)propionamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2003 Jun 5;46(12):2361-75
N(4)-(2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-phenylsuccinamide  0   *Hydroxamic Acids Matrix Metalloproteinases/antagonists & inhibitors. Br J Pharmacol 2002 Apr;135(7):1655-64
N(4)-(2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide  0   *Hydroxamic Acids Metalloendopeptidases/antagonists & inhibitors Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2002 May 23;45(11):2289-93
CH6631  0   *Hydroxamic Acids *Sulfonamides Matrix Metalloproteinases/antagonists & inhibitors. J Periodontal Res 2002 Feb;37(1):1-7
CH1766  0   *Carrier Proteins Matrix Metalloproteinases/antagonists & inhibitors. J Periodontal Res 2002 Feb;37(1):1-7
matrix metalloproteinase-like protein, Gnathostoma spinigerum  EC 3.4.24.-   *Glycoproteins *Helminth Proteins *Matrix Metalloproteinases. Parasitol Res. 2001 Sep;87(9):751-7
N-((2S)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3- dimethyl-L-Valinamide  259188-38-0   *Imidazoles Matrix Metalloproteinases. J Natl Cancer Inst 2001 Feb 7;93(3):178-93
SI 27  0   *Oligopeptides Matrix Metalloproteinases/antagonists & inhibitors. J Neurooncol 2000 Jul;48(3):217-23
MMI 166  0   *Sulfonamides Matrix Metalloproteinases/antagonists & inhibitors. Clin Exp Metastasis. 2000;18(1):61-6
Dm1 matrix metalloproteinase  EC 3.4.24.-   *Matrix Metalloproteinases. J Biol Chem 2000 Nov 17;275(46):35978-85
OSU8 1  0   *Hydroxamic Acids Alanine/*analogs & derivatives Matrix Metalloproteinases/antagonists & inhibitors. J Cell Biol 2000 Oct 16;151(2):209-19
ONO 4817  0   *Phenyl Ethers Matrix Metalloproteinases/antagonists & inhibitors. Inflamm Res 2000 Apr;49(4):144-6
Cs1-MMP protein, Cucumis sativus  EC 3.4.24.-   *Plant Proteins *Matrix Metalloproteinases. Plant Physiol 2000 Jul;123(3):917-27
PGE 1132881  0   *Hydroxamic Acids Protease Inhibitors Matrix Metalloproteinases/antagonists & inhibitors. J Pharm Biomed Anal 1999 Mar;19(3-4):343-9
N-hydroxy-4-((4--methoxyphenyl)sulfonyl)-2,2-dimethylhexahydro-1,4-thiazepine-3-carboxamide 1,1-dioxide  0   *Cyclic S-Oxides *Thiazepines Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4547-62
N-hydroxy-4-((4-methoxyphenyl)sulfonyl)-2,2-dimethylhexahydro-1,4-thiazepine-3-carboxamide  0   *Thiazepines Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4547-62
CA-matrix metalloproteinases  EC 3.4.24.-   *Matrix Metalloproteinases. FEBS Lett 1999 Aug 27;457(2):262-70
MMP23B protein, human  EC 3.4.24.-   *Matrix Metalloproteinases. J Biol Chem 1999 Feb 19;274(8):4570-6
CMMP matrix metalloproteinase, chicken  EC 3.4.24.-   *Matrix Metalloproteinases *Avian Proteins. J Biol Chem 1998 Jul 10;273(28):17893-900
prinomastat  0   *Organic Chemicals Matrix Metalloproteinases. J Natl Cancer Inst 1998 Jul 1;90(13):960-1
Bay 12-9566  0   *Organic Chemicals Matrix Metalloproteinases. J Natl Cancer Inst 1998 Jul 1;90(13):960-1

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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