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Receptor Protein-Tyrosine Kinases

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Definition: A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.  DF: PTK RECEPT   
Examples fms-Like Tyrosine Kinase 3; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-ret; Receptor Tyrosine Kinase-like Orphan Receptors; Receptor, Epidermal Growth Factor; Receptor, erbB-2; Receptor, erbB-3; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptor, Fibroblast Growth Factor, Type 3; Receptor, Fibroblast Growth Factor, Type 4; Receptor, IGF Type 1; Receptor, Insulin; Receptor, Macrophage Colony-Stimulating Factor; Receptor, trkA; Receptor, trkB; Receptor, trkC; Receptors, Eph Family; Receptors, Platelet-Derived Growth Factor; Receptors, TIE; Receptors, Vascular Endothelial Growth Factor 		Other names Receptors, Protein Tyrosine Kinase; Receptors, PTK; Receptor, Protein-Tyrosine Kinase; Receptor Protein Tyrosine Kinases; Receptor Protein Tyrosine Kinase; Protein-Tyrosine Kinases, Receptor; Protein-Tyrosine Kinase, Receptor; Protein-Tyrosine Kinase Receptors; Kinases, Receptor Protein-Tyrosine; Kinase, Receptor Protein-Tyrosine; Receptor Protein-Tyrosine Kinase; Protein-Tyrosine Kinase Receptor; PTK Receptors; Tyrosine Kinase Receptors; Tyrosine Kinase Linked Receptors; Receptors, Protein-Tyrosine Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MuSK protein, Xenopus  EC 2.7.1.112   *Receptors, Cholinergic *Receptor Protein-Tyrosine Kinases *Xenopus Proteins. PLoS One. 2011;6(10) (dup#11); e26805
cabozantinib  0   *Anilides *Pyridines Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Curr Opin Endocrinol Diabetes Obes 2009 Oct;16(5):367-72
Ryk protein, zebrafish  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases *Zebrafish Proteins. J Cell Biol. 2010 Jul 26;190(2):263-78
At2g36570 protein, Arabidopsis  EC 2.7.11.-   *Receptor Protein-Tyrosine Kinases *Arabidopsis Proteins. Planta. 2009 Mar;229(4):811-21
Ryk protein, Xenopus  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases. J Cell Biol 2008 Sep 22;182(6):1073-82
1-(4-(3-amino-7-methoxybenzo(d)isoxazol-4-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea  0   *Isoxazoles *Phenylurea Compounds Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1231-41
Tyro3 protein, rat  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases. Neuroscience 2007 Dec 5;150(2):319-34
CAM-1 protein, C elegans  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Caenorhabditis elegans Proteins. Development 2007 Nov;134(22):4053-62
7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-methoxyethoxy)prop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno(1,2-c)pyrazole  0   *Pyrazoles *Thiophenes Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2007 May 3;50(9):2011-29
6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxyprop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno(1,2-c)pyrazole  0   *Pyrazoles *Thiophenes Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2007 May 3;50(9):2011-29
MuSK protein, zebrafish  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Zebrafish Proteins. Protein Sci 1998 Jul;7(7):1632-5
5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide  0   *Indoles *Morpholines Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Mol Cancer Ther 2006 Jul;5(7):1774-82
N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea  0   *Indazoles *Phenylurea Compounds Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Mol Cancer Ther 2006 Apr;5(4):995-1006
Tyro3 protein, mouse  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases. Nat Immunol 2006 Jul;7(7):747-54
MuSK protein, mouse  EC 2.7.10.1   *Receptor Protein-Tyrosine Kinases. Science 2006 Jun 23;312(5781):1802-5
DDR1 protein, rat  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases. Proc Natl Acad Sci U S A 1994 Mar 1;91(5):1819-23
RYK protein, Drosophila  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Drosophila Proteins. Dev Genes Evol 2005 Mar;215(3):158-63
CEP 2563  0   *Carbazoles *Dipeptides Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Invest New Drugs 2004 Nov;22(4):449-58
scrambled protein, Arabidopsis  EC 2.7.1.-   *Protein-Serine-Threonine Kinases *Receptor Protein-Tyrosine Kinases *Arabidopsis Proteins. Science 2005 Feb 18;307(5712):1111-3
off-track protein, Drosophila  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Drosophila Proteins. Development 2004 Nov;131(21):5287-95
LIN-18 protein, C elegans  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Caenorhabditis elegans Proteins. J Biol Chem 1999 Mar 12;274(11):7379-90
EPHA3 protein, human  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases.
Mertk protein, mouse  EC 2.7.1.112   *Proto-Oncogene Proteins *Receptor Protein-Tyrosine Kinases.
Mertk protein, rat  EC 2.7.1.112   *Proto-Oncogene Proteins *Receptor Protein-Tyrosine Kinases.
LTK protein, human  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases.
NOK protein, mouse  EC 2.7.1.112   *Oncogene Proteins *Receptor Protein-Tyrosine Kinases. Cancer Res 2004 May 15;64(10):3491-9
PTK7 protein, Xenopus  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases. Nature 2004 Jul 1;430(6995):93-8
Ptk7 protein, mouse  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases. Gene 2004 Mar 17;328:75-84
SmRTK-2, Schistosoma mansoni  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases Helminth Proteins. J Soc Biol. 2003;197(4):367-73
SmRTK-1, Schistosoma mansoni  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases Helminth Proteins. J Soc Biol. 2003;197(4):367-73
SER receptor, Schistosoma mansoni  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases Helminth Proteins. J Soc Biol. 2003;197(4):367-73
Ryk protein, rat  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases.
Ros1 protein, rat  EC 2.7.1.112   *Proto-Oncogene Proteins *Receptor Protein-Tyrosine Kinases Protein-Tyrosine Kinases.
Ros1 protein, mouse  EC 2.7.1.112   *Proto-Oncogene Proteins *Receptor Protein-Tyrosine Kinases Protein-Tyrosine Kinases.
STYK1 protein, human  EC 2.7.10.2   *Receptor Protein-Tyrosine Kinases. Mol Biol Rep 2003 Jun;30(2):91-6
MuSK protein, rat  EC 2.7.1.-   *Receptors, Cholinergic *Receptor Protein-Tyrosine Kinases. Structure (Camb). 2002 Sep;10(9):1187-96
SU 11657  0   *Organic Chemicals Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Blood 2003 Apr 15;101(8):3188-97
Pvr protein, Drosophila  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Drosophila Proteins Receptors, Platelet-Derived Growth Factor Receptors, Vascular Endothelial Growth Factor. Cell 2001 Oct 5;107(1):17-26
lemon protein, Hydra vulgaris  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases. Dev Biol 2000 Aug 15;224(2):286-98
inrpk1 protein, Ipomoea nil  EC 2.7.1.-   *Plant Proteins *Receptor Protein-Tyrosine Kinases Ipomoea. Plant Mol Biol 2000 May;43(1):43-58
3-(2-(5-bromo-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl)propionic acid  0   *Indoles *Propionic Acids Receptors, Growth Factor/antagonists & inhibitors Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2000 Jul 13;43(14):2655-63
3-(2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl)propionic acid  0   *Indoles *Propionic Acids Receptors, Growth Factor/antagonists & inhibitors Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2000 Jul 13;43(14):2655-63
sweet tooth protein, Hydra vulgaris  EC 2.7.11.-   *Receptor Protein-Tyrosine Kinases Lectins, C-Type. J Biol Chem 2000 Apr 7;275(14):10323-30
LRPKM1 protein, Malus domestica  EC 2.7.11.-   *Plant Proteins *Receptor Protein-Tyrosine Kinases. Plant Mol Biol 1999 Aug;40(6):945-57
CLV1 protein, Arabidopsis  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases *Arabidopsis Proteins. Cell 1997 May 16;84(4):575-85
Ryk protein, mouse  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases. J Biol Chem 1999 Mar 12;274(11):7379-90
PD 173074  0   *Pyrimidines Receptors, Fibroblast Growth Factor/antagonists & inhibitors Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. EMBO J 1998 Oct 15;17(20):5896-904
NSK2 protein, Drosophila  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases *Drosophila Proteins. Oncogene 1995 Jul 20;11(2):281-90
ET(B)R-LP-2 protein, human  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases Nerve Tissue Proteins. FEBS Lett 1998 Mar 13;424(3):193-6
vab-1 protein, C elegans  EC 2.7.1.112   *Cell Cycle Proteins *Receptor Protein-Tyrosine Kinases *Caenorhabditis elegans Proteins. Cell 1998 Mar 6;92(5):633-43
Epha3 protein, rat  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases. Am J Physiol 1998 Jan;274(1 Pt 2):H331-41
GAP-1 protein, C elegans  EC 2.7.1.-   *ras GTPase-Activating Proteins *Receptor Protein-Tyrosine Kinases *Caenorhabditis elegans Proteins. Genes Dev 1997 Oct 15;11(20):2715-28
Ki 6783  0   *Quinolines Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Exp Cell Res 1997 Aug 1;234(2):285-92
EPHB6 protein, human  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases. Biochem Biophys Res Commun 1997 Jun 27;235(3):487-92
6,7-dimethoxy-3-phenylquinoxaline  146535-11-7   *Tyrphostins Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Biochemistry 1997 May 27;36(21):6260-9
Nrk protein, Drosophila  EC 2.7.1.-   *Nerve Tissue Proteins *Receptor Protein-Tyrosine Kinases *Drosophila Proteins. J Biol Chem 1997 May 2;272(18):11916-23
SDZ 281 977  0   *Benzoates Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. Int J Cancer 1996 Jan 26;65(3):351-9
MERTK protein, human  EC 2.7.1.112   *Proto-Oncogene Proteins *Receptor Protein-Tyrosine Kinases. Cell Growth Differ 1994 Jun;5(6):647-57; Hum Mol Genet 2000 Mar 1;9(4):645-51; Mol Cell Biol 1995 Dec;15(12):6582-92
PTK7 protein, human  EC 2.7.1.-   *Cell Adhesion Molecules *Receptor Protein-Tyrosine Kinases. Oncogene 1995 Nov 16;11(10):2179-84
TCK recceptor-tyrosine kinase, Xenopus  EC 2.7.1.-   *Receptor Protein-Tyrosine Kinases *Xenopus Proteins. Oncogene 1995 Nov 2;11(9):1745-52
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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