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Mitogen-Activated Protein Kinase Kinases

More information in Books or onNLM PubMed
Definition: A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.     
See Also MAP Kinase Signaling System
Examples MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 3; MAP Kinase Kinase 4; MAP Kinase Kinase 5; MAP Kinase Kinase 6; MAP Kinase Kinase 7 		Other names Mitogen Activated Protein Kinase Kinases; MAPK ERK Kinases; MAP ERK Kinase; Kinases, MAPK-ERK; Kinases, MAPK; Kinases, MAP Kinase; Kinase, Map Kinase; Kinase, MAP-ERK; Kinase Kinases, MAP; Kinase Kinase, Map; Map Kinase Kinase; MAPKK; MAP-ERK Kinase; MEKs; MAPK-ERK Kinases; MAPK Kinases; MAP Kinase Kinases; MAPKKs
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MKKK20 protein, Arabidopsis  EC 2.7.12.2   *Mitogen-Activated Protein Kinase Kinases *Arabidopsis Proteins. Plant Cell Rep. 2012 Jan;31(1):217-24
MKK2 protein, S cerevisiae  EC 2.7.12.2   *Mitogen-Activated Protein Kinase Kinases *Saccharomyces cerevisiae Proteins. Proc Natl Acad Sci U S A 2011 Jun 14;108(24):9809-14
4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide  0   *Aniline Compounds *Pyridones Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5090-102
MKK5 protein, Arabidopsis  EC 2.7.1.-   *Arabidopsis *Mitogen-Activated Protein Kinase Kinases. Plant Cell 2007 Jan;19(1):63-73
MKK4 protein, Arabidopsis  EC 2.7.1.-   *Mitogen-Activated Protein Kinase Kinases *Arabidopsis Proteins. Plant Cell 2007 Jan;19(1):63-73
PK7 protein, Plasmodium falciparum  EC 2.7.1.-   *Protozoan Proteins *Mitogen-Activated Protein Kinase Kinases. Mol Microbiol 2005 Jan;55(1):184-96
Lk6 protein, Drosophila  EC 2.7.1.37   *Mitogen-Activated Protein Kinase Kinases *Drosophila Proteins. Curr Biol 2005 Jan 11;15(1):19-23
MKK2 protein, Arabidopsis  EC 2.7.1.37   *Mitogen-Activated Protein Kinase Kinases *Arabidopsis Proteins. Mol Cell 2004 Jul 2;15(1):141-52
BCK1 protein, Pneumocystis carinii  EC 2.7.1.37   *Mitogen-Activated Protein Kinase Kinases. FEBS Lett 2003 Jul 31;548(1-3):59-68
AtMPK3 protein, Arabidopsis  EC 2.7.1.-   *Mitogen-Activated Protein Kinase Kinases *Arabidopsis Proteins. Plant J 2002 Mar;29(5):637-47
SIMKK protein, Medicago sativa  EC 2.7.10.-   *Plant Proteins *Mitogen-Activated Protein Kinase Kinases. Plant Cell 2000 Nov;12(11):2247-58
MAP kinase kinase ubc5  EC 2.7.10.-   *Mitogen-Activated Protein Kinase Kinases. Mol Plant Microbe Interact 2000 Jul;13(7):781-6
salicylic acid-induced protein kinase kinase  EC 2.7.10.-   *Mitogen-Activated Protein Kinase Kinases. Mol Plant Microbe Interact 2000 Jan;13(1):118-24
HST7 protein, Candida albicans  EC 2.7.1.37   *Fungal Proteins *Mitogen-Activated Protein Kinase Kinases. Mol Gen Genet 1995 Dec 20;249(6):609-21
STE7 protein, S cerevisiae  EC 2.7.1.-   *Protein Kinases *Mitogen-Activated Protein Kinase Kinases *Saccharomyces cerevisiae Proteins. Genes Dev 1992 Jul;6(7):1305-18
hemipterous protein, Drosophila  EC 2.7.1.-   *Mitogen-Activated Protein Kinase Kinases *Drosophila Proteins.
win1 protein, S pombe  EC 2.7.10.-   *Mitogen-Activated Protein Kinase Kinases *Schizosaccharomyces pombe Proteins. EMBO J 1997 Oct 15;16(20):6162-70
DdMEK1 protein, Dictyostelium discoideum  EC 2.7.10.-   *Protozoan Proteins *Mitogen-Activated Protein Kinase Kinases. EMBO J 1997 Jul 16;16(14):4317-32
Fuz7 protein, Ustilago maydis  EC 2.7.10.-   *Fungal Proteins *Mitogen-Activated Protein Kinase Kinases. Genes Dev 1994 Jun 15;8(12):1367-78
PBS2 protein, S cerevisiae  EC 2.7.12.2   *Mitogen-Activated Protein Kinase Kinases *Saccharomyces cerevisiae Proteins. Yeast 1994 Apr;10(4):425-39
BCK1 protein, S cerevisiae  EC 2.7.1.37   *Mitogen-Activated Protein Kinase Kinases *Saccharomyces cerevisiae Proteins. Gene 1991;108(1):139; Mol Cell Biol 1992;12(1):172
wis1 protein, S pombe  EC 2.7.10.-   *Mitogen-Activated Protein Kinase Kinases *Schizosaccharomyces pombe Proteins. EMBO J 1991;10(13):4291

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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