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omega-Conotoxins

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Definition: A family of structurally related neurotoxic peptides from mollusk venom that inhibit voltage-activated entry of calcium into the presynaptic membrane. They selectively inhibit N-, P-, and Q-type calcium channels.     
Pharmacological Action Calcium Channel Blockers; Neurotoxins
Examples omega-Conotoxin GVIA 		Other names omega Conotoxins; omega Conotoxin; omega-Conotoxin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
omega-conotoxin-FVIA, Conus fulmen  0   *omega-Conotoxins. Mol Pain 2010;6:97
SO3 conotoxin, Conus striatus  0   *omega-Conotoxins. Peptides 1999;20(10):1139-44
psi-conotoxin PIIIF  0   *omega-Conotoxins. Biochemistry 2003 Jun 3;42(21):6353-62
AM336  0   *omega-Conotoxins. Pain 2002 Mar;96(1-2):119-27
psi-conotoxin PIIIE  0   *omega-Conotoxins Sodium Channels. Biochemistry 1997 Aug 5;36(31):9581-7
omega-conotoxin PnVIB  0   *omega-Conotoxins. J Neurochem 1996 Nov;67(5):2155-63
omega-conotoxin PnVIA  0   *omega-Conotoxins. J Neurochem 1996 Nov;67(5):2155-63
omega-conotoxin TxVII  0   *omega-Conotoxins Mollusk Venoms. Biochemistry 1996 Jul 2;35(26):8748-52
omega-conotoxin TVIA  137688-12-1 omega-Conotoxin G VIA (reduced), 2-L-leucine-23-L-serine-24-L-arginine-25-L-lysine-27-L-argininamide  *omega-Conotoxins Neuropeptides. Neurosci Lett 1994 Jan 3;165(1-2):157-60
omega-conotoxin RVIA, Conus radiatus  137688-17-6   *omega-Conotoxins. Int J Dev Neurosci 1994 Feb;12(1):43-7
ziconotide  107452-89-1   *omega-Conotoxins Calcium Channels, N-Type.
Pharma Action Calcium Channel Blockers ; Neuroprotective Agents ; Analgesics, Non-Narcotic 		J Cardiovasc Pharmacol 1992;20(5):756-64PRIALT
omega-conotoxin SVIA  137706-81-1 L-Threoninamide, L-cysteinyl-L-arginyl-L-seryl-L-serylglycyl-L-seryl-trans-4-hydroxy-L-prolyl-L-cysteinylglycyl-L-valyl-L-threonyl-L-seryl-L-isoleucyl-L-cysteinyl-L-cysteinylglycyl-L-arginyl-L-cysteinyl-L-tyrosyl-L-arginylglycyl-L-lysyl-L-cysteinyl  *omega-Conotoxins. Biochemistry 1992 Oct 20;31(41):9919-26
omega-conotoxin SVIB  137706-83-3 omega-Conotoxin M VIIA (reduced), 3-L-leucine-6-L-glutamine-7-L-serine-17-L-serine-20a-endo-L-serine-, cyclic (1-16),(8-20),(15-25)-tris(disulfide)  *omega-Conotoxins. Biochemistry 1992 Oct 20;31(41):9919-26
omega-conotoxin-MVIIC  147794-23-8   *omega-Conotoxins.
Pharma Action Calcium Channel Blockers 		Neuron 1992 Jul;9(1):69-77
Conus magus toxin  107407-86-3   *omega-Conotoxins.
Pharma Action Calcium Channel Blockers 		J Neurosci 1987;7(8):2390-6
omega-conotoxin receptor  0   *Calcium Channels omega-Conotoxins. J Biol Chem 1987;262(20):9877

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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