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Protein Sorting Signals

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Definition: Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.     
See Also Protein Transport; Signal Recognition Particle
Examples Nuclear Export Signals; Nuclear Localization Signals 		Other names Leader Signal Peptide; Leader Sequence, Peptide; Leader Peptides; Signal Sequences, Peptide; Signal Sequences; Signal Sequence, Peptide; Signal Peptides; Signal Peptide; Peptide Signal Sequences; Peptide Leader Sequences; Leader Sequences, Peptide; Leader Peptide; Sorting Signals, Protein; Sorting Signal, Protein; Signals, Protein Sorting; Signal, Protein Sorting; Signal Sequence; Signal Peptides, Leader; Signal Peptide, Leader; Sequences, Signal
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
M9 nuclear localization signal peptide  0   *Peptide Fragments *Protein Sorting Signals *Heterogeneous-Nuclear Ribonucleoprotein Group A-B Nuclear Localization Signals. J Cell Biol 1995 May;129(3):551-60
Scube3 protein, mouse  0   *Glycoproteins Epidermal Growth Factor Protein Sorting Signals. J Biol Chem 2004 Sep 3;279(36):37485-90
SCUBE3 protein, human  0   *Calcium-Binding Proteins Epidermal Growth Factor Protein Sorting Signals. J Biol Chem 2004 Sep 3;279(36):37485-90
IFT81 protein, human  0   *Muscle Proteins Protein Sorting Signals. Mol Biol Rep. 2002 Dec;29(4):353-62
latency-associated propeptide, TGF-beta  0   *Peptides *Protein Precursors *Transforming Growth Factor beta Protein Sorting Signals. Connect Tissue Res 2002;43(2-3):381-6
Scube2 protein, mouse  0   *Intercellular Signaling Peptides and Proteins Epidermal Growth Factor Protein Sorting Signals. Mech Dev 2001 Apr;102(1-2):209-11
Scube1 protein, mouse  0   *Intercellular Signaling Peptides and Proteins Protein Sorting Signals. Genomics 2000 Nov 15;70(1):74-81
SPA4CT protein, recombinant  0   *Peptide Fragments *Recombinant Proteins *Amyloid beta-Protein Precursor Membrane Proteins Protein Sorting Signals. FEBS Lett 1999 Jun 25;453(3):288-92
dvnA protein, Carnobacterium divergens  0   *Bacteriocins Protein Sorting Signals. J Bacteriol 1995 Jun;177(11):3143-9
pro-OmpA nuclease A  0   *Bacterial Outer Membrane Proteins *Micrococcal Nuclease *Protein Precursors Protein Sorting Signals. Biochemistry 1995 Mar 28;34(12):3935-41
Qdm protein, mouse  0   *Peptides Histocompatibility Antigens Class I Protein Sorting Signals. Cell 1994 Nov 18;79(4):649-58
iCF10 peptide precursor, Plasmid pCF10  0   *Bacterial Proteins *Protein Sorting Signals. J Bacteriol 1994 Dec;176(23):7405-8
LamB signal peptide, E coli  0   *Protein Sorting Signals *Escherichia coli Proteins. Biochemistry 1993 Dec 21;32(50):13991-9
NS4B protein, flavivirus  0   *Viral Nonstructural Proteins Protein Sorting Signals. J Virol 1993 Apr;67(4):2327-35
NS4A protein, flavivirus  0   *Viral Nonstructural Proteins Protein Sorting Signals. J Virol 1993 Apr;67(4):2327-35
chloroplast transit peptides  0   *Protein Sorting Signals *Chloroplast Proteins. FEBS Lett 1992 Dec 21;314(3):232-6
histidyl-aspartyl-glutamyl-leucine  129623-52-5   *Oligopeptides *Protein Sorting Signals. J Cell Sci 1992 Jan;102(Pt 2):261-71
translational activator peptide, E coli  0   *Protein Sorting Signals *Escherichia coli Proteins. EMBO J 1992 Jul;11(7):2675-83
gamma-transit peptide, Chlamydomonas reinhardtii  0   *Algal Proteins *Protein Sorting Signals Chloroplasts. Biochemistry 1992 Jun 2;31(21):5053-9
lysyl-aspartyl-glutamyl-leucine  113516-56-6   *Oligopeptides *Protein Sorting Signals. J Biol Chem 1992 Apr 5;267(10):7072-6
SEKDEL sequence  123924-38-9   *Protein Sorting Signals. J Cell Biol 1989;109(6 Pt 1):2633
pre-proparathyroid hormone (29+1) amide, Tyr(1)-Ala(14)-Nle(18,21,25)  108998-59-0   *Parathyroid Hormone *Protein Precursors *Protein Sorting Signals. Mol Endocrinol 1988;2(5):452
pretrypsinogen signal sequence peptide  104582-22-1   *Protein Sorting Signals Trypsinogen. Biochem J 1986;238(1):301
prolipoprotein signal peptide  0   *Bacterial Outer Membrane Proteins *Protein Sorting Signals. J Biol Chem 1985;260(20):10961

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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