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Receptors, Adrenergic, beta-3

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Definition: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The beta-3 adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.      Other names beta-3 Receptors, Adrenergic; beta-3 Receptor, Adrenergic; beta 3 Adrenergic Receptors; Receptors, beta 3 Adrenergic; Receptors, Adrenergic beta-3; Receptor, Adrenergic beta 3; Adrenoreceptor, beta3; Adrenergic beta 3 Receptors; Adrenergic beta 3 Receptor; Adrenergic Receptors, beta 3; beta3 Adrenoreceptor; Receptor, Adrenergic beta-3; Adrenergic beta-3 Receptor; Adrenergic Receptors, beta-3; beta-3 Adrenergic Receptors; Receptors, beta-3 Adrenergic; Adrenergic beta-3 Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ADRB3 protein, human  0   *Receptors, Adrenergic, beta-3. Br J Sports Med. 2011 Feb;45(2):147-9
4'-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)-2-(pyrazin-2-yl)acetanilide  0   *Acetanilides *Pyrazines Receptors, Adrenergic, beta-3/agonists. Eur J Med Chem 2009 Jun;44(6):2533-43
4'-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)-2-(pyrimidin-2-yl)acetanilide  0   *Acetanilides *Pyrimidines Receptors, Adrenergic, beta-3/agonists. Eur J Med Chem 2009 Jun;44(6):2533-43
4'-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)-2-(2-pyridyl)acetanilide  0   *Acetanilides *Pyridines Receptors, Adrenergic, beta-3/agonists. Eur J Med Chem 2009 Jun;44(6):2533-43
4'-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)-3-methoxybiphenyl-4-carboxylic acid  0   *Biphenyl Compounds *Phenethylamines Receptors, Adrenergic, beta-3/agonists. Br J Pharmacol 2009 Jan;156(1):127-34
3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic acid  0   *Aniline Compounds *Benzoic Acids Receptors, Adrenergic, beta-3/agonists. J Pharmacol Exp Ther 2007 Oct;323(1):202-9
ethyl 4-(4-((2-hydroxy-3-(4-hydroxy-3-((methylsulfonyl)amino)phenoxy)propyl)amino)cyclohexyl)benzoate  0   *Benzoates *Sulfonamides Receptors, Adrenergic, beta-3/agonists. J Pharmacol Exp Ther 2007 Jun;321(3):1118-26
2-(2-aminothiazol-4-yl)-4'-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)acetanilide  0   *Acetanilides *Thiazoles Receptors, Adrenergic, beta-3. J Pharmacol Exp Ther 2007 May;321(2):642-7
2,3-dihydrothiopyrano(2,3-b)pyridine  0   *Pyridines Receptors, Adrenergic, beta-3/antagonists & inhibitors. Bioorg Med Chem 2003 Nov 17;11(23):4921-31
ethyl 2-(2-chloro-4-(2-((2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)phenoxy)acetate  0   Norepinephrine/*analogs & derivatives Receptors, Adrenergic, beta-3/agonists. J Med Chem 2003 Jan 2;46(1):105-12
2-(2-chloro-4-(2-((2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)phenoxy)acetic acid  0   Norepinephrine/*analogs & derivatives Receptors, Adrenergic, beta-3/agonists. J Med Chem 2003 Jan 2;46(1):105-12
N-((3-((2-((2-hydroxy-2-(3-chlorophenyl)ethyl)amino)propyl)amino)phenyl)acetyl)-4-methylbenzenesulfonamide  0   *Aniline Compounds *Sulfonamides Receptors, Adrenergic, beta-3/agonists. J Med Chem 2002 Jan 31;45(3):567-83
N-((4-((2-((2-hydroxy-2-(3-chlorophenyl)ethyl)amino)propyl)amino)phenyl)acetyl)-4-methylbenzenesulfonamide  0   *Aniline Compounds *Sulfonamides Receptors, Adrenergic, beta-3/agonists. J Med Chem 2002 Jan 31;45(3):567-83
L 750355  0   *Aminopyridines *Sulfonamides Receptors, Adrenergic, beta-3/antagonists & inhibitors. Eur J Pharmacol 2000 Oct 27;407(1-2):175-81
N-(4-(2-((2-hydroxy-2-(3-pyridinyl)ethyl)amino)ethyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide  0   *Sulfonamides *Thiazoles Receptors, Adrenergic, beta-3/agonists. J Med Chem 2000 Oct 19;43(21):3832-6
CL 316243  138908-40-4   *Dioxoles Receptors, Adrenergic, beta-3/agonists.
Pharma Action Adrenergic beta-Agonists ; Hypoglycemic Agents 		J Med Chem1992 Aug 7;35(16):3081-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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