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Defensins

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Definition: Family of antimicrobial peptides that have been identified in humans, animals, and plants. They are thought to play a role in host defenses against infections, inflammation, wound repair, and acquired immunity.     
Pharmacological Action Anti-Infective Agents
Examples alpha-Defensins; beta-Defensins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lucifensin  0   *Defensins. Chembiochem. 2011 Jun 14;12(9):1352-61
PDF1.2a protein, Arabidopsis  0   *Defensins *Arabidopsis Proteins. New Phytol 2010 Sep;187(4):1075-88
PDF1.1 protein, Arabidopsis  0   *Defensins *Arabidopsis Proteins. New Phytol 2010 Sep;187(4):1075-88
neutrophil defensin hNP2, human  0   *Defensins. Org Lett. 2011 Feb 18;13(4):568-71
protaetiamycine protein, Protaetia brevitarsis  0   *Insect Proteins *Defensins. J Pept Sci 2009 Sep;15(9):559-68
AdDLP protein, Anaeromyxobacter dehalogenans  0   *Defensins Bacterial Proteins. Biochem Biophys Res Commun. 2009 Sep 18;387(2):393-8
gallerimycin  0   *Defensins Moths. Biol Chem. 2006 May;387(5):549-57
limenin protein, Phaseolus limensis  0   *Defensins HIV Reverse Transcriptase/antagonists & inhibitors. J Pept Sci 2006 May;12(5):341-6
retrocyclin-2, human  0   *Peptides, Cyclic *Defensins. Biophys J 2006 May 15;90(10):3616-24
phaseococcin protein, Phaseolus coccineus  0   *Defensins. Biochem Cell Biol 2005 Apr;83(2):212-20
PDF1.2 protein, Arabidopsis  0   *Defensins *Arabidopsis Proteins. Plant J 2004 May;38(4):626-38
cucurmoschin protein, Cucurbita moschata  0   *Defensins. Peptides 2003 Jul;24(7):969-72
gymnin protein, Gymnocladus chinensis  0   *Defensins HIV Reverse Transcriptase/antagonists & inhibitors. Peptides 2003 Jul;24(7):963-8
beta defensin-1 protein, rat  0   *Defensins. Biochem Biophys Res Commun 2003 Oct 17:310(2):513-21
theta-defensin  0   *Defensins. Proc Natl Acad Sci U S A 2002 Feb 19;99(4):1813-8
rhesus theta defensin-3  0   *Defensins *Peptides, Cyclic. J Biol Chem 2002 Feb 1;277(5):3079-84
rhesus theta defensin-2  0   *Peptides, Cyclic *Defensins. J Biol Chem 2002 Feb 1;277(5):3079-84
defensin B, Anomala cuprea  0   *Defensins. Insect Biochem Mol Biol 2001 Dec;32(1):75-84
defensin A, Anomala cuprea  0   *Defensins. Insect Biochem Mol Biol 2001 Dec;32(1):75-84
DEFB118 protein, human  0   *Defensins Epididymis. Endocrinology 2001 Oct;142(10):4529-39
tgas118, Lycopersicon esculentum  0   *Plant Proteins *Defensins Plant Proteins. J Exp Bot 2001 Jul;52(360):1427-36
RTD-3 protein, Macaca mulatta  0   *Defensins. J Leukoc Biol 2001 Sep;70(3):461-4
RTD-2 protein, Macaca mulatta  0   *Defensins. J Leukoc Biol 2001 Sep;70(3):461-4
BD-6 protein, mouse  0   *Defensins Muscle Proteins. J Biol Chem 2001 Aug 24;276(34):31510-4
defensin 1, Pisum sativum  0   *Plant Proteins *Defensins. Arch Biochem Biophys 2000 Jun 15;378(2):278-86
defensin 2 protein, Pisum sativum  0   *Plant Proteins *Defensins. Arch Biochem Biophys 2000 Jun 15;378(2):278-86
scorpine  0   *Defensins Scorpion Venoms. FEBS Lett 2000 Apr 14;471(2-3):165-8
peptide NP-5  0   *Defensins.
peptide NP-3b  0   *Defensins.
defensin NP-2  0   *Defensins.
Ah-AMP1protein, Aesculus hippocastanum  0   *Plant Proteins *Defensins. Proteins 1999 Nov 15;37(3):388-403
MGD-1 protein, Mytilus  0   *Defensins. Eur J Biochem 1996 aug 15;240(1):302-6
SPI1 protein, Picea abies  0   *Plant Proteins *Defensins. Plant Mol Biol 1996 Jun;31(3):707-12
Dm-AMP1 protein, Dahlia merckii  0   *Plant Proteins *Defensins. J Biol Chem 1996 Jun 21;271(25):15018-25
RK-1 protein, Oryctolagus cuniculus  0   *Defensins. J Biol Chem 1996 May 3;271(18):10654-9
CRS4C protein, mouse  0   *Protein Precursors *Defensins. Genomics 1994 Nov 1;24(1):99-109
gallinacin 2 protein, chicken  156409-45-9   *Defensins *Avian Proteins. FEBS Lett 1994 Apr 11;342(3):281-5
gallinacin 1 protein, chicken  156409-55-1   *Defensins *Avian Proteins. FEBS Lett 1994 Apr 11;342(3):281-5
defensin protein, Aeshna cyanea  144855-46-9   *Insect Proteins *Defensins. Eur J Biochem 1992 Nov 1;209(3):977-84
insect defensin B  0   *Defensins. Proc Natl Acad Sci USA 1989;86(1):262
insect defensin A  0   *Defensins. Proc Natl Acad Sci USA 1989;86(1):262

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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