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Tocopherols

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Definition: A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a long hydrocarbon chain of isoprenoid units. They are antioxidants by virtue of the phenolic hydrogen. Tocopherols react with the most reactive form of oxygen and protect unsaturated fatty acids from oxidation.  deficiency: coordinate TOCOPHEROLS with VITAMIN E DEFICIENCY   
Pharmacological Action Antioxidants; Vitamins
Examples alpha-Tocopherol; beta-Tocopherol; gamma-Tocopherol 		Other names d alpha Tocopheryl Acetate; Vitamin Emp; Vitamin E, Vitagutt; Vitamin E, Togasan; Vitamin E, Mowivit; Vitamin E mp; Vitamin E EVI MIRALE; Vitamin E Dragees; VitaPlus E; VitaE; Vita Plus E; Vita E; UnoVit; Uno Vit; Tocopherol ratiopharm Brand; Tocopherol Worwag Brand; Tocopherol Wiedemann Brand; Tocopherol Verla Brand; Tocopherol Twardy Brand; Tocopherol Togal Brand
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
alpha-tocopherol-5-fluorouracil  0   *Tocopherols Fluorouracil/*analogs & derivatives. Chem Commun (Camb). 2011 Oct 14;47(38):10713-5
pentoxifylline-tocopherol-clodronate  0   *Clodronic Acid *Pentoxifylline *Tocopherols Drug Combinations Osteoradionecrosis/drug therapy Bone Density Conservation Agents. Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3);832-9
germanium L-cysteine alpha-tocopherol complex  0   *Cysteine *Organometallic Compounds *Tocopherols Germanium. Acta Pharm. 2007 Mar;57(1):1-12
all-rac-alpha-selenotocopherol  0   *Selenium Compounds *Tocopherols. J Org Chem. 2006 Feb 3;71(3):992-1001
2,5,7,8-tetramethylchroman-2-(9-(7-nitrobenz(1,2,5)oxadiazol-4-ylamino)nonyl)chroman-6-ol  0   *Tocopherols 4-Chloro-7-nitrobenzofurazan/*analogs & derivatives. Biochemistry 2006 Jan 31;45(4):1075-81
delta-tocopherol glucoside  0   *Glucosides *Tocopherols. J Control Release. 2004 Nov 24;100(2):221-31
2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid  0   *Tocopherols. Cancer Res 2004 Jun 15;64(12):4263-9
delta-tocopherol  119-13-1   *Tocopherols. J Nutr 2003 Oct;133(10):3137-40
tocopherol monoglucoside  0   *Glucosides Tocopherols. J Radiat Res (Tokyo) 2002 Mar;43(1):99-106
7-formyl-5,8-dimethyltocol  0   *Tocopherols. Chem Pharm Bull (Tokyo) 2000 Jan;48(1):71-6
5-formyl-7,8-dimethyltocol  0   *Tocopherols. Chem Pharm Bull (Tokyo) 2000 Jan;48(1):71-6
3,4-dihydro-2-(2-dimethylaminoethyl)-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol  130611-21-1   *Tocopherols. Biochem Biophys Acta 1991;1095(1):23
2,4,6,7-tetramethyl-2-(4',8',12'-trimethyltridecyl)-5-hydroxy-3,4-dihydrobenzofuran  105172-88-1   *Tocopherols. FEBS Lett 1986;205(1):117
2,8-dimethyl-2-(2'-carboxyethyl)-6-chromanol  0   *Tocopherols. J Lipid Res 1984;25(1):40
5-nicotinooxymethyl-alpha-tocopherylnicotinate  51605-68-6 3-Pyridinecarboxylic acid, 3,4-dihydro-2,7,8-trimethyl-5-(((3-pyridinylcarbonyl)oxy)methyl)-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester  *Tocopherols. Clin Exp Hypertens 1982(A)4:177

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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