Glycogen Phosphorylase (definition)

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ψ	Glycogen Phosphorylase

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Definition: An enzyme that catalyzes the degradation of GLYCOGEN in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. This enzyme exists in two forms: an active phosphorylated form ( PHOSPHORYLASE A) and an inactive un-phosphorylated form (PHOSPHORYLASE B). Both a and b forms of phosphorylase exist as homodimers. In mammals, the major isozymes of glycogen phosphorylase are found in muscle, liver and brain tissue.

GEN or unspecified; prefer specifics
Examples Glycogen Phosphorylase, Brain Form; Glycogen Phosphorylase, Liver Form; Glycogen Phosphorylase, Muscle Form

Other names Phosphorylase, Glycogen; Phosphorylase ab

Substance	CAS Registry & name	Categories	Source
3,3'-(hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy))bisolean-12-en-28-oic acid	0	Triazoles Oleanolic Acid/analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors.	Chem Biodivers 2010 Mar;7(3):690-7
iminobis(ethane-2,1-diylimino(3b)-28-oxoolean-12-ene-28,3-diyl) diacetate	0	Oleanolic Acid/*analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors.	Chem Biodivers 2010 Mar;7(3):690-7
2-(3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl)-N-(3'',4''-dichlorobenzyl)acetamide	0	*Pyridones Glycogen Phosphorylase/antagonists & inhibitors.	Bioorg Med Chem 2009 Jul 1;17(13):4724-33
glucopyranosylidene-spiro-oxathiazole	0	Thiazoles Glucose/analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors.	Bioorg Med Chem Lett 2008 Oct 15;18(20):5680-3
glycogen phosphorylase BB, human	EC 2.4.1.-	*Glycogen Phosphorylase Biological Markers.	Vnitr Lek 2007 Nov;53(11):1164-9
2-chloro-N-(1-(2,3-dihydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno(2,3-b)pyrrole-5-carboxamide	0	Thiophenes Quinolones Glycogen Phosphorylase.	Br J Pharmacol 2007 Dec;152(8):1239-47
glucopyranose spirohydantoin	0	Hydantoins Glucose/analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors.	Proteins 2005 Dec 1;61(4):966-83
3,4-dideoxyglucosone-3-ene	0	*Pyrones Glycogen Phosphorylase/antagonists & inhibitors.	Diabetes 2005 Aug;54(8):2424-9
2-glucopyranosyl-5-methylbenzothiazole	0	Thiazoles Glucosides Glycogen Phosphorylase/antagonists & inhibitors.	Protein Sci 2005 Apr;14(4):873-88
2-glucopyranosyl-5-methylbenzimidazole	0	Benzimidazoles Glucosides Glycogen Phosphorylase/antagonists & inhibitors.	Protein Sci 2005 Apr;14(4):873-88
2-glucopyranosyl-5-methyl-1,3,4-oxadiazole	0	Glucosides Oxadiazoles Glycogen Phosphorylase/antagonists & inhibitors.	Protein Sci 2005 Apr;14(4):873-88
4-(2-(3-nitrobenzoylamino)phenoxy)phthalic acid	0	Benzamides Phthalic Acids Glycogen Phosphorylase/antagonists & inhibitors.	J Med Chem 2004 Jul 1;47(14):3537-45
4-(2,4-bis-(3-nitrobenzoylamino)phenoxy)phthalic acid	0	Benzamides Phthalic Acids Glycogen Phosphorylase/antagonists & inhibitors.	J Med Chem 2004 Jul 1;47(14):3537-45
N-benzoyl-N'-glucopyranosylurea	0	Glucose/analogs & derivatives Urea/analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors.	Eur J Biochem 2002 Mar;269(6):1684-96
N-acetyl-N'-glucopyranosylurea	0	Glucose/analogs & derivatives Urea/analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors.	Eur J Biochem 2002 Mar;269(6):1684-96

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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