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Vacuolar Proton-Translocating ATPases

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Definition: Proton-translocating ATPases that are involved in acidification of a variety of intracellular compartments.      Other names Vacuolar H+ ATPase; V Type ATPase; Proton-Translocating ATPases, Lysosomal; Lysosomal Proton Translocating ATPases; H+-ATPase, Vacuolar; ATPases, Lysosomal Proton-Translocating; ATPase, Vacuolar; ATPase, V-Type; Vacuolar Membrane H(+)-ATPase; Vacuolar H+-ATPase; Vacuolar F(1)F(0) ATPases; Vacuolar F(1)F(0) ATPase; Vacuolar ATPase; V-Type ATPase; Lysosomal Proton-Translocating ATPases; Lysosomal F(1)F(0) ATPase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
vacuolar ATPase V0 subunit A2, rat  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Mol Biol Chem. 2011 Sep;22(18):3394-409.
vacuolar ATPase V0 subunit A1, rat  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases Protein Subunits. J Biol Chem. 2006 Jun 23;281(25):17164-72.
ATP6V1H protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases Protein Subunits. Invest Ophthalmol Vis Sci 2009 Feb;50(2):893-905
VMA2 protein, S cerevisiae  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins Protein Subunits. J Bioenerg Biomembr 1989 Oct;21(5):589-603
ATP6V1C1 protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Cancer Biol Ther. 2010 Jun 15;9(12):1057-64
Vha100-1 protein, Drosophila  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Drosophila Proteins. J Cell Biol 2010 May 31;189(5):885-99
ATP6V0D2 protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Biochem Biophys Res Commun 2009 Dec 18;390(3):525-90
Atp6v0d2 protein, mouse  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. J Bone Miner Res 2009 May;24(5):871-85
ATP6V0C protein, human  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases. Cancer Lett 2009 Jul 18;280(1):110-9
VMA6 protein, S cerevisiae  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. Biochim Biophys Acta 2009 Apr;1787(4):242-51
VMA21 protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Cell 2009 Apr 17;137(2):235-46
RTA 203  0   *Bicyclo Compounds, Heterocyclic Vacuolar Proton-Translocating ATPases/antagonists & inhibitors. Int J Cancer 2009 Mar 1;124(5):1060-71
VHA-a1 protein, Arabidopsis  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Arabidopsis Proteins Protein Subunits. Proc Natl Acad Sci U S A 2008 Jun 17;105(24):8464-9
ATP6V0A1 protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Anticancer Res 2008 Mar-Apr;28(2B):1221-7
V-ATPase subunit A, zebrafish  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Zebrafish Proteins Protein Subunits. Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5); R2068-76
V-ATPase 55-kDa B subunit, Drosophila  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Drosophila Proteins. J Biol Chem 1996 Nov 29;271(48):30677-84
4-(5,6-dichloro-1H-indol-2-yl)-3-ethoxy-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide  0   *Benzamides *Indoles Vacuolar Proton-Translocating ATPases/antagonists & inhibitors. J Pharmacol Exp Ther 2006 Sep;318(3):939-46
VHA-5 protein, C elegans  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Caenorhabditis elegans Proteins. J Biol Chem 2001 Aug 31;276(35):33079-85
v-ATPase subunit a1, rat  EC 3.6.1.   *Vacuolar Proton-Translocating ATPases Protein Subunits. J Biol Chem 2006 Jun 23;281(25):17164-72
VHA-8 protein, C elegans  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Caenorhabditis elegans Proteins Protein Subunits. FEBS Lett 2006 May 29;580(13):3161-6
methyl 5-(5,6-dichloro-2-indolyl)-2-methoxy-2,4-pentadienoate  0   *Indoles *Valerates Vacuolar Proton-Translocating ATPases/antagonists & inhibitors. Biochemistry 2006 Apr 25;45(16):5271-9
ATP6V1B1 protein, human  EC 3.6.1.34   *Vacuolar Proton-Translocating ATPases. Clin Genet 2006 Feb;69(2):135-44
2,6-dichloro-N-(3-methyl-4-(3-methyl-2-oxo-1-imidazolidinyl)-8-quinolinyl)benzamide  0   *Aminoquinolines *Benzamides Vacuolar Proton-Translocating ATPases/antagonists & inhibitors. J Toxicol Sci 2005 Dec;30(4):297-304
vha-3 protein, C elegans  0   *Vacuolar Proton-Translocating ATPases *Caenorhabditis elegans Proteins.
vha-2 protein, C elegans  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases *Caenorhabditis elegans Proteins.
vha-11 protein, C elegans  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases *Caenorhabditis elegans Proteins.
unc-32 protein, C elegans  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Caenorhabditis elegans Proteins.
Atp6v0b protein, mouse  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases.
ATP6V0B protein, human  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases.
ATP6V1G2 protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Tissue Antigens 2005 Sep;66(3):200-8
Det3 protein, Arabidopsis  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Arabidopsis Proteins Protein Subunits. Plant J 2005 Aug;43(3):348-55
Atp6v1c2 protein, mouse  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases Protein Subunits.
TUFF protein, Arabidopsis  0   *Arabidopsis Proteins Vacuolar Proton-Translocating ATPases. Plant J 2005 Jan;41(1):125-32
Vma4 protein, S cerevisiae  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. Biochemistry 2005 Mar 15;44(10):3933-41
FR 167356  0   *Benzamides *Benzofurans Vacuolar Proton-Translocating ATPases/antagonists & inhibitors. Br J Pharmacol 2004 Jun;142(3):558-66
VPS4A protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
ATP6V0A4 protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases.
VMA9 protein, S cerevisiae  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. J Biol Chem 2004 Apr 23;279(17):17361-5
VMA10 protein, S cerevisiae  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. J Exp Biol. 2003 Sep;206(Pt 18):3227-3p7
Ac45 protein, Xenopus  0   *Xenopus Proteins *Vacuolar Proton-Translocating ATPases.
Atp6ap1 protein, mouse  0   *Vacuolar Proton-Translocating ATPases.
Atp6v1b1 protein, mouse  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Gene 2003 Oct 30;318:25-34
Atp6v1c1 protein, mouse  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases Protein Subunits. J Biol Chem 2003 Nov 7;278(45):44843-51
chondropsin C  0   *Macrolides Vacuolar Proton-Translocating ATPases/antagonists & inhibitors. J Biol Chem 2003 Nov 7;278(45):44147-52
V-ATPase a subunit, S cerevisiae  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins Protein Subunits. J Biol Chem 2003 Oct 24;278(43):41908-13
CUP5 protein, S cerevisiae  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. J Biol Chem 2003 Oct 24;278(43):41908-13
TCIRG1 protein, human  0   *Vacuolar Proton-Translocating ATPases. Hum Mutat 2003 Feb;21(2);151-7; Immunity 1998 Oct;9(4):509-18
V-ATPase G subunit, mouse  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. J Biol Chem 2002 Sep 27;277(39):36296-303
ATP6V1E2 protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases. Gene 2002 May 1;289(1-2):7-12
ATP6AP2 protein, human  0   *Receptors, Cell Surface *Vacuolar Proton-Translocating ATPases Renin. J Clin Invest 2002 Jun;109(11):1417-27
VMA13 protein, S cerevisiae  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. J Biol Chem 1993 Aug 25;268(24):18286-92
VMA5 protein, S cerevisiae  EC 3.6.3.14   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. J Biol Chem 1993 Jan 5;268(1):221-7
V-ATPase subunit E, Manduca sexta  EC 3.6.1.-   *Insect Proteins *Vacuolar Proton-Translocating ATPases. Biochim Biophys Acta 1994 Feb 23;1190(1):193-6
VMA8 protein, S cerevisiae  0   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. Proc Natl Acad Sci U S A 1995 Jan 17;92(2):497-501
VMA7 protein, S cerevisiae  0   *Vacuolar Proton-Translocating ATPases *Saccharomyces cerevisiae Proteins. J Biol Chem 1994 Sep 30;269(39):24150-5
ATP6AP1 protein, human  0   *Vacuolar Proton-Translocating ATPases. J Biol Chem 1994 Sep 30;269(39):24102-6
ductin  0   *Proteolipids *Vacuolar Proton-Translocating ATPases. Exp Cell Res 1993 Aug;207(2):261-70
proton pump polypeptide 116K  135846-03-6   *Vacuolar Proton-Translocating ATPases Nerve Tissue Proteins. J Biol Chem 1991;266(6):3877

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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