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Tumor Suppressor Proteins

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Definition: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.     
See Also Genes, Tumor Suppressor
Examples Adenomatous Polyposis Coli Protein; Antigens, CD82; BRCA1 Protein; BRCA2 Protein; Cyclin-Dependent Kinase Inhibitor Proteins; Cystatin M; Kisspeptins; Neurofibromin 1; Neurofibromin 2; PTEN Phosphohydrolase; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; Retinoblastoma Protein; Smad4 Protein; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53; Von Hippel-Lindau Tumor Suppressor Protein; WT1 Proteins 		Other names Proteins, Tumor Suppressor; Proteins, Metastasis Suppressor; Proteins, Growth Suppressor; Metastasis Suppressor Proteins; Growth Suppressor Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RASSF5 protein, rat  0   *Tumor Suppressor Proteins. Apoptosis. 2012 Jan;17(1):14-24
RASSF2 protein, mouse  0   *Tumor Suppressor Proteins. EMBO J. 2012 Mar 7;31(5):1147-59
Zc3h12d protein, mouse  0   *Tumor Suppressor Proteins Zinc Fingers. Cell Signal. 2012 Feb;24(2):569-76.
FAM123A protein, human  0   *Tumor Suppressor Proteins *Adaptor Proteins, Signal Transducing. J Biol Chem. 2012 Jan 13;287(3):1734-41
KANK1-PDGFRbeta fusion protein, human  0   *Oncogene Proteins, Fusion Receptor, Platelet-Derived Growth Factor beta Tumor Suppressor Proteins. Haematologica. 2011 Oct;96(10):1406-14.
Paip2 protein, mouse  0   *Tumor Suppressor Proteins. PLoS One. 2011;6(9):e25116.
SARI protein, human  0   *Tumor Suppressor Proteins *Basic-Leucine Zipper Transcription Factors. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20906-11.
melanoma inhibitory activity protein 2, mouse  0   *Tumor Suppressor Proteins src Homology Domains. Gut. 2008 Feb;57(2):243-51.
LZTS2 protein, mouse  0   *DNA-Binding Proteins *Cell Cycle Proteins *Tumor Suppressor Proteins Leucine Zippers. J Biol Chem. 2011 Nov 18;286(46):40331-42
ZNF668 protein, human  0   *Tumor Suppressor Proteins Zinc Fingers. Cancer Res. 2011 Oct 15;71(20):6524-34.
C10orf97 protein, human  0   *Tumor Suppressor Proteins. Oncogene. 2011 Sep 29;30(39):4107-17.
HOTS protein, human  0   *Nuclear Proteins *Tumor Suppressor Proteins. Proc Natl Acad Sci U S A 2011 Oct 4;108(40):16759-64
SLAN protein, human  0   *Tumor Suppressor Proteins. J Thorac Oncol 2011 Jun;6(6):988-97
FRMD3 protein, human  0   *Tumor Suppressor Proteins. Oncogene 2007 Jun 28;26(30):4464-8
Lzap protein, zebrafish  0   *Tumor Suppressor Proteins *Zebrafish Proteins. Dev Dyn 2011 Jun;240(6):1613-25
LAPSER1 protein, Xenopus  0   *Tumor Suppressor Proteins *Xenopus Proteins Leucine Zippers. Dev Dyn 2011 Jun;240(6):1528-36
UVRAG protein, Drosophila  0   *Tumor Suppressor Proteins *Drosophila Proteins. Dev Biol 2011 Aug 15;356(2):588-97
OTAG-12 protein, mouse  0   *Tumor Suppressor Proteins. Oncogene 2011 Jun 23;30(25):2874-87
OTAG-12 protein, human  0   *Tumor Suppressor Proteins. Oncogene 2011 Jun 23;30(25):2874-87
RASSF1 protein, rat  0   *Tumor Suppressor Proteins Protein Isoforms. Biomed Environ Sci. 2011 Apr;24(2):163-71
Samd9L protein, mouse  0   *Tumor Suppressor Proteins. J Invest Dermatol 2011 Jul;131(7):1428-34
GLTSCR1 protein, human  0   *Tumor Suppressor Proteins. Mol Cell Biol 2011 Jul;31(13):2641-52
HSS1 protein, mouse  0   *Tumor Suppressor Proteins. J Neurooncol 2011 Apr;102(2):197-211
CtIP protein, Xenopus  0   *Tumor Suppressor Proteins *Xenopus Proteins. Mol Cell 2009 Dec 25;36(6):954-69
checkpoint with FHA and RING finger domains protein, mouse  EC 6.3.2.19   *Tumor Suppressor Proteins *Ubiquitin-Protein Ligases. J Cell Sci 2011 Feb 15;124(Pt 4):532-9
NPCEDRG protein, human  0   *Tumor Suppressor Proteins Nasopharyngeal Neoplasms. Mol Cell Biochem. 2011 Jan;346(1-2):1-10
NOL7 protein, human  0   *Nuclear Proteins *Tumor Suppressor Proteins. BMC Cell Biol 2010;11:74
C1orf190 protein, human  0   *Tumor Suppressor Proteins NF-kappa B/agonists. J Immunol 2010 Dec 1;185(11):6719-27
killin protein, human  0   *Tumor Suppressor Proteins. JAMA. 2010 Dec 22;304(24):2724-31
Palb2 protein, mouse  0   *Tumor Suppressor Proteins. Hum Mol Genet 2010 Aug 1;19(15):3021-9
L3MBTL1 protein, mouse  0   *Nuclear Proteins *Tumor Suppressor Proteins. J Biol Chem 2010 Sep 3;285(36):27767-75
alpha-fetoprotein enhancer binding protein, human  0   *Carrier Proteins *Tumor Suppressor Proteins. Dis Markers. 2010;28(3):125-35
PDGFRL protein, human  0   *Receptors, Platelet-Derived Growth Factor *Tumor Suppressor Proteins. World J Gastroenterol 2010 Mar 28;16(12):1465-72
Lin9 protein, mouse  0   *Tumor Suppressor Proteins. Mol Cell Biol 2010 Jun;30(12):2896-908
YPEL3 protein, human  0   *Tumor Suppressor Proteins. Cancer Res 2010 May 1;70(9):3566-75
MFSD2A protein, human  0   *Tumor Suppressor Proteins Membrane Transport Proteins. Mol Cancer 2010;9:62
DRR1 protein, rat  0   *Tumor Suppressor Proteins. Biochem Biophys Res Commun 2010 Apr 9;394(3):829-35
DRR1 protein, mouse  0   *Tumor Suppressor Proteins. Biochem Biophys Res Commun 2010 Apr 9;394(3):829-35
scribble protein, rat  0   *Tumor Suppressor Proteins. J Neurosci 2010 Mar 31;30(13):4796-805
RASSF10 protein, human  0   *Tumor Suppressor Proteins. Epigenetics 2009 Nov;4(8):571-6
kibra protein, Drosophila  0   *Tumor Suppressor Proteins *Drosophila Proteins. Dev Cell 2010 Feb 16;18(2):288-99
RASSF8 protein, Drosophila  0   *Carrier Proteins *Drosophila Proteins Tumor Suppressor Proteins. Curr Biol 2009 Dec 15;19(23):1969-78
ASPP protein, Drosophila  0   *Drosophila Proteins Ankyrin Repeat Tumor Suppressor Proteins. Dev Cell 2007 Dec;13(6):773-82
scribbled protein, Drosophila  0   *Tumor Suppressor Proteins *Drosophila Proteins. Nature 2010 Jan 28;463(7280):545-8
CCBE1 protein, human  0   *Calcium-Binding Proteins *Tumor Suppressor Proteins. Br J Cancer 2010 Jan 5;102(1):87-96
MIPOL1 protein, human  0   *Tumor Suppressor Proteins. Proc Natl Acad Sci U S A 2009 Aug 25;106(34):14478-83
Tusc2 protein, rat  0   *Tumor Suppressor Proteins.
Tusc2 protein, mouse  0   *Tumor Suppressor Proteins.
DEAR1 protein, human  0   *Tumor Suppressor Proteins Zinc Fingers. PLoS Med 2009 May 26;6(5):e1000068
Mats1 protein, zebrafish  0   *Tumor Suppressor Proteins *Zebrafish Proteins. Int J Dev Biol 2009;53(4):525-33
Vhl protein, zebrafish  0   *Tumor Suppressor Proteins *Zebrafish Proteins. Blood 2009 Jun 18;113(25):6449-60
Smyd4 protein, mouse  0   *Tumor Suppressor Proteins. Cancer Res 2009 May 1;69(9):4067-72
Apc1 protein, zebrafish  0   *Zebrafish Proteins *Tumor Suppressor Proteins Carrier Proteins. Zebrafish 2009 Mar;6(1):41-7
ING4 protein, mouse  0   *Carrier Proteins *Tumor Suppressor Proteins Zinc Fingers. Respir Res 2009;10:14
mitostatin protein, human  0   *Tumor Suppressor Proteins. Oncogene 2009 Jan 15;28(2):257-69
PRDM5 protein, zebrafish  0   *Tumor Suppressor Proteins *Zebrafish Proteins Carrier Proteins Zinc Fingers. PLoS ONE 2009;4(1):e4273
Axud1 protein, Drosophila  0   *Tumor Suppressor Proteins *Drosophila Proteins. Mech Dev 2009 Mar-Apr;126(3-4):184-97
Vps4 protein, Drosophila  EC 3.6.1.3   *Adenosine Triphosphatases *Drosophila Proteins *Endosomal Sorting Complexes Required for Transport Tumor Suppressor Proteins. PLoS ONE 2009;4(2):e4354
FAT4 protein, human  0   *Cadherins *Tumor Suppressor Proteins. Int J Cancer 2009 Feb 15;124(4):793-8
ZC3H10 protein, human  0   *Carrier Proteins Zinc Fingers Tumor Suppressor Proteins. Biochem Biophys Res Commun 2008 Nov 28;376(4):748-52
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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