Tumor Suppressor Protein p14ARF (definition)

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ψ ψ	Tumor Suppressor Protein p14ARF

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Definition: A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.

See Also Cyclin-Dependent Kinase Inhibitor p16; Genes, p16

Other names p14ARF; p14(ARF); p(ARF) Protein; Cdkn2a(p14ARF); p14ARF Protein

Substance	CAS Registry & name	Categories	Source	Drugs*
p19(ARF) protein, rat	0	*Tumor Suppressor Protein p14ARF.	Nephron Physiol 2005;101(2):p27-34

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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