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Symporters

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Definition: Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.     
See Also Ion Transport
Examples Dopamine Plasma Membrane Transport Proteins; GABA Plasma Membrane Transport Proteins; Glutamate Plasma Membrane Transport Proteins; Glycine Plasma Membrane Transport Proteins; Norepinephrine Plasma Membrane Transport Proteins; Proton-Coupled Folate Transporter; Proton-Phosphate Symporters; Serotonin Plasma Membrane Transport Proteins; Sodium Chloride Symporters; Sodium-Coupled Vitamin C Transporters; Sodium-Glucose Transport Proteins; Sodium-Bicarbonate Symporters; Sodium-Phosphate Cotransporter Proteins; Sodium-Potassium-Chloride Symporters 		Other names Co Transporters; Co-Transporters
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
sodium-myo-inositol cotransporter, rat  0   *Symporters. Eur J Pharm Sci. 2012 Jan 23;45(1-2):73-8
SMIT2 protein, mouse  0   *Symporters. PLoS One. 2011;6(8):e24032.
SLC13A3 protein, human  0   *Symporters *Organic Anion Transporters, Sodium-Dependent. Invest Ophthalmol Vis Sci. 2011 Sep;52(10) (dup#3):7625-33
Slc4a11 protein, mouse  0   *Anion Transport Proteins *Symporters. J Biol Chem 2009 Sep 25;284(39):26882-96
BAT5 protein, Arabidopsis  0   *Organic Anion Transporters, Sodium-Dependent *Arabidopsis Proteins Symporters. Plant Cell 2009 Jun;21(6):1813-29
Slc10a7 protein, human  0   *Symporters *Organic Anion Transporters, Sodium-Dependent. Int J Androl 2009 Jun;32(3):226-30
INOSITOL TRANSPORTER 2, Arabidopsis  0   *Symporters *Arabidopsis Proteins. Plant Physiol 2007 Dec;145(4):1395-407
Slc10a5 protein, mouse  0   *Symporters *Organic Anion Transporters, Sodium-Dependent. Biochem Biophys Res Commun 2007 Sep 14;361(1):26-32
SLC10A5 protein, human  0   *Symporters *Organic Anion Transporters, Sodium-Dependent. Biochem Biophys Res Commun 2007 Sep 14;361(1):26-32
SLC5A12 protein, human  0   *Monocarboxylic Acid Transporters *Symporters. J Biol Chem 2007 Apr 20;282(16):11996-2009
SLC5A7 protein, human  0   *Symporters. Exp Biol Med (Maywood) 2006 May;231(5):490-504
STP13 protein, Arabidopsis  0   *Symporters *Arabidopsis Proteins. FEBS Lett 2006 Apr 17;580(9):2381-7
SLC5A3 protein, mouse  0   *Symporters. Cytogenete Cell Genet 2000;88(1-2):153-8
Slc13a4 protein, rat  0   *Symporters *Organic Anion Transporters, Sodium-Dependent. Pflugers Arch. 2005 Jul;450(4):262-8
potassium transporter, Arabidopsis  0   *Symporters *Arabidopsis Proteins. Plant Physiol 2005 Mar;137(3):1105-14
nadc2 protein, Xenopus  0   *Symporters *Xenopus Proteins.
Tscot protein, mouse  0   *Symporters.
SLC12A3 protein, human  0   *Receptors, Drug *Symporters Diuretics.
Slc12a3 protein, rat  0   *Receptors, Drug *Symporters.
Slc12a3 protein, mouse  0   *Receptors, Drug *Symporters.
Slc36a1 protein, rat  0   *Amino Acid Transport Systems, Neutral *Symporters. Gastroenterology 2004 Nov;127(5);1410-22
OPT6 protein, Arabidopsis  0   *Symporters *Arabidopsis Proteins. Plant Physiol 2004 Jul;135(3):1378-87
NaDC3 protein, mouse  0   *Symporters *Organic Anion Transporters, Sodium-Dependent. Biochim Biophys Acta 2004 Sep 6;1690(1):63-9
Slc12a7 protein, rat  0   *Symporters.
Slc12a7 protein, mouse  0   *Symporters.
KCC3 protein, rat  0   *Symporters.
Slc12a6 protein, mouse  0   *Symporters.
Slc13a2 protein, mouse  0   *Symporters *Organic Anion Transporters, Sodium-Dependent *Dicarboxylic Acid Transporters.
Slc13a2 protein, rat  0   *Symporters *Organic Anion Transporters, Sodium-Dependent *Dicarboxylic Acid Transporters.
HKT1 protein, Arabidopsis  0   *Cation Transport Proteins *Symporters *Arabidopsis Proteins.
Slc15a1 protein, mouse  0   *Symporters Dipeptides.
Slc15a1 protein, rat  0   *Symporters Dipeptides.
SNF-6 protein, C elegans  0   *Symporters *Caenorhabditis elegans Proteins. Nature 2004 aug 19;430(7002):891-6
Slc13a5 protein, mouse  0   *Symporters *Dicarboxylic Acid Transporters. Biochem J 2004 Mar 15;378(Pt 3):949-57
SLC36A2 protein, human  0   *Amino Acid Transport Systems, Neutral *Symporters. Genomics 2003 Jul;82(1):47-56
Slc36a1 protein, mouse  0   *Amino Acid Transport Systems *Symporters. J Biol Chem 2004 Jan 23;279(4):2754-60
SLC36A1 protein, human  0   *Amino Acid Transport Systems *Symporters. J Physiol 2003 Jan 15;546(Pt 2):349-61
Slc36a2 protein, rat  0   *Amino Acid Transport Systems, Neutral *Symporters. Biochem Biophys Res Commun 2003 May 16;304(4):747-54
DUR3 protein, Arabidopsis  0   *Symporters *Arabidopsis Proteins. Plant Cell 2003 Mar;15(3):790-800
SLC13A5 protein, human  0   *Symporters. Biochem Biophys Res Commun 2002 Dec 6;299(3):465-71
Slc13a5 protein, rat  0   *Symporters. J Biol Chem 2002 Oct 18;277(42):39469-76
Slc36a2 protein, mouse  0   *Amino Acid Transport Systems, Neutral *Symporters. J Biol Chem 2002 Jun 21;277(25):22966-73
YclF protein, Bacillus subitillis  0   *Bacterial Proteins *Symporters. J Bacteriol 2001 Dec;183(24):7329-40
FEN2 protein, S cerevisiae  0   *Symporters *Saccharomyces cerevisiae Proteins.
sodium-dependent dicarboxylate transporter 2, rat  0   *Symporters *Organic Anion Transporters, Sodium-Dependent *Dicarboxylic Acid Transporters.
sialic acid transport proteins  0   *Organic Anion Transporters *Symporters Sialic Acid Storage Disease.
monocarboxylate transport protein 1  0   *Monocarboxylic Acid Transporters *Symporters.
Itr2 protein, Mesembryanthemum crystallinum  0   *Plant Proteins *Symporters. Plant J 2000 Nov;24(4):511-22
Itr1 protein, Mesembryanthemum crystallinum  0   *Plant Proteins *Symporters. Plant J 2000 Nov;24(4):511-22
Indy protein, Drosophila  0   *Symporters *Dicarboxylic Acid Transporters *Drosophila Proteins. Science. 2000 Dec 15;290(5499):2137-40
opt-3 protein, C elegans  0   *Nerve Tissue Proteins *Symporters *Caenorhabditis elegans Proteins. J Biol Chem 2000 Mar 31;275(13):9563-71
SLC46A2 protein, human  0   *Symporters Membrane Glycoproteins. J Immunol 2000 Mar 15;164(6):3185-92
Agp2 protein, S cerevisiae  0   *Amino Acid Transport Systems *Symporters *Saccharomyces cerevisiae Proteins. EMBO J 1999 Nov 1;18(21):5843-52
SLC13A4 protein, human  0   *Anion Transport Proteins *Symporters Biological Transport. Proc Natl Acad Sci U S A 1999 Oct 26;96(22):12772-7
pantothenate transporter  0   *Symporters. J Biol Chem 1999 Jun 25;274(26):18747-52
biotin transporter  0   *Symporters Biological Transport, Active Biotin Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins. J Biol Chem 1998 Mar 27;273(13):7501-6; J Biol Chem 1999 Jun 23;274(26):18741-6
SLC12A7 protein, human  0   *Symporters. J Biol Chem 1999 Jun 4;274(23):16355-62
SLC12A6 protein, human  0   *Symporters. J Biol Chem 1999 Jun 4;274(23):16355-62
JEN1 protein, S cerevisiae  0   *Symporters *Monocarboxylic Acid Transporters *Saccharomyces cerevisiae Proteins. J Bacteriol 1999 Apr;181(8):2620-3
xylT protein, Lactobacillus  0   *Bacterial Proteins *Symporters. Appl Environ Microbiol 1998 Dec;64(12):4720-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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