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Karyopherins

More information in Books or onNLM PubMed
Definition: A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.     
See Also Active Transport, Cell Nucleus
Examples alpha Karyopherins; beta Karyopherins 		Other names Transportins; Transportin; Exportins; Importin; Importins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
exportin 6, mouse  0   *Karyopherins. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):E544-52.
exportin 6 protein, human  0   *Karyopherins. Exp Cell Res. 2011 Apr 15;317(7):941-54
importin 4, mouse  0   *Karyopherins. Mol Cell Biol 2008 Jul;28(13):4331-41
importin 13, rat  0   *Karyopherins. Biochim Biophys Acta. 2010 Aug;1803(8):968-74
XPO1A protein, Arabidopsis  0   *Receptors, Cytoplasmic and Nuclear *Karyopherins *Arabidopsis Proteins. New Phytol. 2010 Jun;186(4):833-42
importin 13 protein, Drosophila  0   *Karyopherins *Drosophila Proteins. J Neurosci. 2009 Apr 29;29(17):5628-39
Srp1 protein, S cerevisiae  0   *Karyopherins *Saccharomyces cerevisiae Proteins. Genetics 20090 Jan;181(1):105-18
importin alpha, Arabidopsis  0   *Karyopherins *Arabidopsis Proteins. Plant Cell 2008 Oct;20(10):2661-80
importin 13, human  0   *Karyopherins. Mol Cell Biochem 2008 Jan;307(1-2):93-100
moleskin protein, Drosophila  0   *Karyopherins *Drosophila Proteins. J Cell Biol 2007 Sep 10;178(6):981-94
importin 13 protein, mouse  0   *Karyopherins. Dev Biol 2006 Sep 15;297(2):350-60
SAD2 protein, Arabidopsis  0   *Karyopherins *Arabidopsis Proteins. Plant J 2006 Sep;47(5):776-87
exportin-5 protein, Drosophila  0   *Karyopherins *Drosophila Proteins. EMBO J 2002 Nov 15;21(22):6205-15
importin 9, rat  0   *Karyopherins. Brain Res Mol Brain Res 2005 Sep 13;139(1):103-14
MOS6 protein, Arabidopsis  0   *Karyopherins *Arabidopsis Proteins. Curr Biol 2005 Jun 21;15(12):1129-35
Xpo5 protein, mouse  0   *Karyopherins.
Xpo4 protein, mouse  0   *Karyopherins.
KAP120 protein, S cerevisiae  0   *Karyopherins *Saccharomyces cerevisiae Proteins. Mol Microbiol 2003 Sep;49(5):1297-307
paused protein, Arabidopsis  0   *Karyopherins *Arabidopsis Proteins. Plant Physiol 2003 Aug;132(4):1913-24
IMB-1 protein, C elegans  0   *Karyopherins *Caenorhabditis elegans Proteins. Mol Biol Cell 2002 Dec;13(12):4355-70
HASTY protein, Arabidopsis  0   *Karyopherins *Arabidopsis Proteins. Development 2003 Apr;130(8):1493-504
Kap119 protein, S cerevisiae  0   *Karyopherins *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2003 Mar;23(6):2042-54
IMA-2 protein, C elegans  0   *Karyopherins *Caenorhabditis elegans Proteins. Mol Biol Cell 2002 Sep;13(9):3138-47
IPO7 protein, human  0   *Karyopherins *Receptors, Cytoplasmic and Nuclear. J Biol Chem 2002 Sep 6;277(36):32480-9
XPO5 protein, human  0   *Karyopherins. J Cell Biol 2002 Jan 7;156(1):53-64
Xpo4 protein, human  0   *Karyopherins. EMBO J. 2000 Aug 15;19(16):4362-71
MSN5 protein, S cerevisiae  0   *Karyopherins *Saccharomyces cerevisiae Proteins. Genetics 1999 Nov;153(3):1219-31
SXM1 protein, S cerevisiae  0   *Karyopherins *Saccharomyces cerevisiae Proteins. J Cell Biol 1997 Dec 29;139(7):1655-61
exportin 1 protein  0   *Receptors, Cytoplasmic and Nuclear *Karyopherins Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins Drosophila Proteins. Mol Cell Biol 1992 Dec;12(12):5474-84

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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