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Dynamins

More information in Books or onNLM PubMed
Definition: A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.  GEN: prefer specifics; see SCR for organism-specific dynamins   
Examples Dynamin I; Dynamin II; Dynamin III 		Other names GTPase Deficient Dynamin; Dynamin, GTPase-Deficient; Dynamin, Mutated Form, K44A; Dynamin, Alanine44 Substituted With Lysine; Dynamin K44A; Dynamin; Dephosphin; GTPase-Deficient Dynamin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
dynamin-related protein 1, C elegans  EC 3.6.5.5   *Caenorhabditis elegans Proteins *Dynamins Membrane Proteins Mitochondrial Proteins. Mol Cell. 1999 Nov;4(5):815-26.
dyngo-4a  0   *Hydrazones *Naphthols Dynamins/antagonists & inhibitors. J Biol Chem. 2011 Oct 14;286(41):35966-76.
DD-11 compound  0   *Hydrazones Dynamins/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Aug 15;20(16):4858-64
DD-6 compound  0   *Hydrazones Dynamins/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Aug 15;20(16):4858-64
DRP1C protein, Arabidopsis  EC 3.6.1.50   *Arabidopsis Proteins *Dynamins. Plant Physiol 2008 Aug;147(4);1590-602
Drp1 protein, rat  EC 3.6.5.5   *Dynamins. J Biol Chem 2007 Apr 13;282(15):11521-9
N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide  0   *Hydrazones Dynamins/antagonists & inhibitors. Dev Cell 2006 Jun;10(6):839-50
Dyn-1 protein, C elegans  EC 3.6.5.5   *Caenorhabditis elegans Proteins *Dynamins. Dev Cell 2006 Jun;10(6):743-57
Dnm1 protein, S pombe  EC 3.6.1.50   *Schizosaccharomyces pombe Proteins *Dynamins. FEBS Lett 2005 Feb 14;579(5):1109-16
Msp1 protein, S pombe  EC 3.6.1.50   *Schizosaccharomyces pombe Proteins *Dynamins. FEBS Lett 2005 Feb 14;579(5):1109-16
Dnm1l protein, mouse  EC 3.6.5.5   *Dynamins.
dynamin-like protein, Trypanosoma brucei  EC 3.6.1.50   *Dynamins. J Biol Chem 2004 Mar 12;279(11):10692-701
ADL1A protein, Arabidopsis  EC 3.6.1.50   *Arabidopsis Proteins *Dynamins. Plant Physiol 2001 May;126(1):47-68
ARC5 protein, Arabidopsis  EC 3.6.1.50   *Arabidopsis Proteins *Dynamins. Proc Natl Acad Sci U S A 2003 Apr 1;100(7):4328-33
shibire protein, Drosophila  EC 3.6.1.50   *Drosophila Proteins *Dynamins.
ADL6 protein, Arabidopsis  EC 3.6.1.-   *Arabidopsis Proteins *Dynamins. Plant Cell 2001 Jul;13(7):1511-26
dynamin A protein, Dictyostelium discoideum  EC 3.6.5.5   *Protozoan Proteins *Dynamins. Mol Biol Cell 1999 Jan;10(1):225-43

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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