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RNA Interference

More information in Books or onNLM PubMed
Definition: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.     
See Also RNA, Small Interfering; RNA-Induced Silencing Complex 		Other names Silencing, Post-Transcriptional Gene; Post-Transcriptional Gene Silencings; Post Transcriptional Gene Silencing; Interference, RNA; Gene Silencings, Posttranscriptional; Gene Silencing, Posttranscriptional; Gene Silencing, Post Transcriptional; Co Suppression; RNA Silencing; Posttranscriptional Gene Silencing; Cosuppression; Co-Suppression; Post-Transcriptional Gene Silencing; Gene Silencing, Post-Transcriptional
 
SubstanceCAS Registry & nameCategoriesSource
Ars2 protein, Drosophila  0   *Drosophila Proteins RNA Interference. Cell 2009 Jul 23;138(2):340-51
Prp19p protein, mouse  0   *Nuclear Matrix-Associated Proteins RNA Interference. J Biol Chem. 2007 Jan 26;282(4):2456-65
MUT-7 protein, C elegans  EC 3.1.-   *Exoribonucleases *Caenorhabditis elegans Proteins RNA Interference. Cell 1999 Oct 15;99(2):133-41

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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