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RNA-Induced Silencing Complex

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Definition: A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).     
See Also RNA Interference; RNA, Small Interfering
Examples Argonaute Proteins 		Other names Silencing Complex, RNA-Induced; RNA Induced Silencing Complex; Nuclease, RISC Multicomponent; Multicomponent Nuclease, RISC; Complex, RNA-Induced Silencing; RISC Multicomponent Nuclease

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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