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MicroRNAs

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Definition: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.     
See Also RNA, Small Interfering 		Other names pri miRNA; pre miRNA; miRNA, Primary; Temporal RNA, Small; RNA, Micro; MicroRNA, Primary; pri-miRNA; pre-miRNA; miRNAs; Primary miRNA; Primary MicroRNA; MicroRNA; Micro RNA; stRNA; miRNA; Small Temporal RNA; RNA, Small Temporal
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MIRN124 microRNA, Drosophila  0   *MicroRNAs. Development. 2012 Apr;139(2):1427-34.
MIRN509 microRNA, human  0   *MicroRNAs. Gene. 2012 Apr 10;497(1):93-7
MIRN508 microRNA, human  0   *MicroRNAs. Biochem Biophys Res Commun. 2012 Mar 23;419(4):621-6
MIRN642 microRNA, human  0   *MicroRNAs. Genome Biol. 2011;12(7):R64
MIRN1266 microRNA, human  0   *MicroRNAs. Eur J Dermatol. 2012 Jan-Feb;22(1):68-71
MIRN187 microRNA, human  0   *MicroRNAs. Oncogene. 2012 Feb 9;31(6):764-75
MIRN98 microRNA-98, rat  0   *MicroRNAs. Circ Res. 2011 Feb 4;108(3):305-13.
MIRN1186 microRNA, mouse  0   *MicroRNAs. Nucleic Acids Res. 2012 Feb;40(4):1695-707.
MIRN744 microRNA, mouse  0   *MicroRNAs. Nucleic Acids Res. 2012 Feb;40(4):1695-707.
MIRN126 microRNA, rat  0   *MicroRNAs. Genes Cells. 2011 Jul;16(7):803-14.
MIRN518 microRNA, human  0   *MicroRNAs. Hypertension. 2012 Feb;59(2):265-73.
MIRN503 microRNA, rat  0   *MicroRNAs. Mol Biol Cell. 2012 Jan;23(1):151-62.
MIRN1236 microRNA, human  0   *MicroRNAs. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):633-42
MIRN489 microRNA, mouse  0   *MicroRNAs. Nature. 2012 Feb 23;482(7386):524-8
MIRN34 microRNA, Drosophila  0   *Drosophila Proteins *MicroRNAs. Curr Biol. 2011 Nov 22;21(22):1878-87.
Mirn15 microRNA, mouse  0   *MicroRNAs. Circ Res. 2012 Jan 6;110(1):71-81
MIRN330 microRNA, human  0   *MicroRNAs. Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1214-22
Mirn141 microRNA, rat  0   *MicroRNAs. Am J Physiol Renal Physiol. 2012 Feb;302(3); F369-79
MIRN28 microRNA, human  0   *MicroRNAs. Breast Cancer Res Treat. 2011 Oct;129(3); 983-91
MIRN35 microRNA, C elegans  0   *MicroRNAs. Cell Res. 2011 Nov;21(11):1605-18
MIRN877 microRNA, human  0   *MicroRNAs. Nucleic Acids Res. 2012 Jan;40(1):438-48.
MIRN31 microRNA, rat  0   *MicroRNAs. J Biol Chem. 2011 Dec 9;286(49):42371-80.
MIRN624 microRNA, human  0   *MicroRNAs. PLoS One. 2011;6(10) (dup#6):e25946
MIRN340 microRNA, human  0   *MicroRNAs. PLoS One. 2011;6(10) (dup#6):e25946
MIRN1826 microRNA, human  0   *MicroRNAs. Carcinogenesis. 2012 Jan;33(1):41-8
Mirn26 microRNA, zebrafish  0   *MicroRNAs. Genes Dev. 2012 Jan 1;26(1):25-30
MIRN330 microRNA, mouse  0   *MicroRNAs. Am J Physiol Renal Physiol. 2012 Jan;302(1):F29-37
MIRN246 microRNA, C elegans  0   *MicroRNAs. PLoS Genet. 2011 Sep;7(9) (dup#6):e1002306
MIRN74 microRNA, C elegans  0   *MicroRNAs. PLoS Genet. 2011 Sep;7(9) (dup#6):e1002306
MIRN239 microRNA, C elegans  0   *MicroRNAs. PLoS Genet. 2011 Sep;7(9) (dup#6):e1002306
MIRN298 microRNA, mouse  0   *MicroRNAs. RNA. 2012 Jan;18(1):135-44.
MIRN298 microRNA, human  0   *MicroRNAs. RNA. 2012 Jan;18(1):135-44.
MIRN296 microRNA, mouse  0   *MicroRNAs. RNA. 2012 Jan;18(1):135-44.
MIRN744 microRNA, human  0   *MicroRNAs. PLoS One. 2011;6(10) (dup#1):e25044
MIRN629 microRNA, human  0   *MicroRNAs. Cell. 2011 Dec 9;147(6):1233-47
MIRN453 microRNA, human  0   *MicroRNAs. Biomed Pharmacother. 2011 Sep;65(6):436-42.
MIRN637 microRNA, human  0   *MicroRNAs. Hepatology. 2011 Dec;54(6):2137-48
MIRN143 microRNA, rat  0   *MicroRNAs. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2909-19
MIRN5787 microRNA, human  0   *MicroRNAs. Biochem Biophys Res Commun. 2011 Dec 2;415(4):567-72.
MIRN125 microRNA, zebrafish  0   *MicroRNAs. PLoS Genet. 2011 Sep;7(9) (dup#3):e1002242
MIRN758 microRNA, mouse  0   *MicroRNAs. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2707-14.
MIRN758 microRNA, human  0   *MicroRNAs. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2707-14.
MIRN208 microRNA, rat  0   *MicroRNAs. J Hypertens. 2011 Aug;29(8):1560-8
MIRN202 microRNA, human  0   *MicroRNAs. Free Radic Biol Med. 2009 Jan 15;46(2):282-8.
MIRN195 microRNA, mouse  0   *MicroRNAs. Circ Res. 2011 Sep 2;109(6):670-9.
MIRN5739 microRNA, human  0   *MicroRNAs. Biochem Biophys Res Commun. 2011 Nov 18;415(2):258-62
MIRN134 microRNA, human  0   *MicroRNAs. J Transl Med. 2011;9() (dup#125):159
MIRN10 microRNA, mouse  0   *MicroRNAs. J Immunol. 2011 Dec 1;187(11):5879-86
MIRN130 microRNA, rat  0   *MicroRNAs. Am J Hypertens. 2011 Oct;24(10):1087-93
MIRN467 microRNA, mouse  0   *MicroRNAs. Biochem Biophys Res Commun. 2011 Nov 4;414(4):664-9
MIRN17-92 microRNA, human  0   *MicroRNAs. EMBO J. 2011 Nov 2;30(21):4450-64
MIRN222 microRNA, rat  0   *MicroRNAs. Mol Biol Cell. 2011 Sep;22(17):3055-69.
MIRN671 microRNA, human  0   *MicroRNAs. Leuk Lymphoma. 2011 Aug;52(8):1567-73
MIRN720 microRNA, human  0   *MicroRNAs. Leuk Lymphoma. 2011 Aug;52(8):1567-73
MIRN32 microRNA, human  0   *MicroRNAs. Cancer Res. 2011 Oct 1;71(19):6230-9
MIRN708 microRNA, human  0   *MicroRNAs. Cancer Res. 2011 Oct 1;71(19):6208-19
MIRN410 microRNA, human  0   *MicroRNAs. Br J Cancer. 2011 Oct 25;105(9):1352-61
MIRN487 microRNA, human  0   *MicroRNAs. Br J Cancer. 2011 Oct 25;105(9):1352-61
MIRN279 microRNA, Drosophila  0   *MicroRNAs. Nat Cell Biol. 2011 Sep;13(9):1062-9
MIRN193 microRNA, mouse  0   *MicroRNAs. J Cell Mol Med. 2011 May;15(5):1071-4
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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