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ADP Ribose Transferases

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Definition: Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.     
Examples Cholera Toxin; Diphtheria Toxin; NAD+ Nucleosidase; Pertussis Toxin; Poly(ADP-ribose) Polymerases; Sirtuins 		Other names Transferases, Mono ADPribose; Transferases, Mono ADP-ribose; Transferases, ART; Transferases, ADP Ribose; Transferase, Mono ADPribose; Transferase, ART; Transferase, ADP Ribose; Ribose Transferases, ADP; Ribose Transferase, ADP; NADP Arginine ADP Ribosyltransferase; NADP ADPRTase; NAD+ ADP Ribosyltransferase; NAD Arginine ADP Ribosyltransferase; NAD Agmatine ADP Ribosyltransferase; NAD ADP Ribosyltransferase; Mono ADP ribose Transferases; Mono ADP Ribosyltransferase; ADPribose Transferases, Mono; ADPribose Transferase, Mono; ADP-ribose Transferases, Mono
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
C0-05 ADP-ribosyltransferase  EC 2.4.2.-   *ADP Ribose Transferases. J Biol Chem 2002 Sep 6;277(36):32820-9
C3-07 ADP-ribosyltransferase  EC 2.4.2.-   *ADP Ribose Transferases. J Neurosci 2005 Feb 2;25(5):1113-21
NarE protein, Neisseria meningitidis  EC 2.4.2.-   *ADP Ribose Transferases. Mol Microbiol 2003 Nov;50(3):1055-67
C3stau2 protein, Staphylococcus aureus  EC 2.4.2.-   *ADP Ribose Transferases. J Biol Chem 2003 Nov 14;278(46):45924-30
ExoT protein, Pseudomonas aeruginosa  0   *GTPase-Activating Proteins *ADP Ribose Transferases Bacterial Toxins. J Biol Chem 2003 Aug 29;278(35):32794-800
Art2b protein, mouse  EC 2.4.2.31   *ADP Ribose Transferases. Mol Cell Biochem. 1999 Mar;193(1-2):61-8
Art2a protein, mouse  EC 2.4.2.31   *ADP Ribose Transferases. Mol Cell Biochem. 1999 Mar;193(1-2):61-8
ART1 protein, human  EC 2.4.2.31   *ADP Ribose Transferases GPI-Linked Proteins.
ART4 protein, mouse  EC 2.4.2.31   *ADP Ribose Transferases.
Art3 protein, mouse  EC 2.4.2.31   *ADP Ribose Transferases GPI-Linked Proteins.
exoenzyme S  EC 2.4.2.31   *Bacterial Toxins *ADP Ribose Transferases Cytotoxins.
spvB protein, Salmonella enterica virulence plasmid  EC 2.4.2.-   *ADP Ribose Transferases *Virulence Factors. Mol Microbiol 2000 Sep;37(5):1106-15
actin-specific ADP-ribosyltransferase, Clostridium  EC 2.4.2.31   *Bacterial Proteins *ADP Ribose Transferases. FEMS Microbiol Lett 2000 May 15;186(2):307-12
ART5 protein, mouse  EC 2.4.2.31   *ADP Ribose Transferases. Gene. 2001 Sep 19;275(2):267-77; Mol Cell Biochem 1999 Mar;193(1-2):109-13
MBP-PE40  0   *Myelin Basic Proteins *Exotoxins *Recombinant Fusion Proteins *ADP Ribose Transferases Immunotoxins. Immunol Lett 1999 Jun 1;68(2-3):403-10
L-GnRH-PE66 protein, chimeric  0   *Exotoxins *Gonadotropin-Releasing Hormone *Recombinant Fusion Proteins *ADP Ribose Transferases. Med Oncol 1999 Apr;16(1):38-45
BMS-191352 protein, recombinant  0   *Bacterial Toxins *Exotoxins *Recombinant Fusion Proteins *ADP Ribose Transferases *Single-Chain Antibodies Immunotoxins. J Immunoassay 1998 May-Aug;19(2-3):145-65
pierisin protein, insect  0   *Insect Proteins *ADP Ribose Transferases Cytotoxins Apoptosis. Jpn J Cancer Res 1998 May;89(5):556-61
ART4 protein, human  EC 2.4.2.31   *Membrane Proteins *ADP Ribose Transferases. Genomics 1997 Feb 1;39(3):370-6
ART3 protein, human  EC 2.4.2.31   *ADP Ribose Transferases GPI-Linked Proteins. Genomics 1997 Feb 1;39(3):370-6
Art2b protein, rat  EC 2.4.2.31   *Antigens, Differentiation, T-Lymphocyte *ADP Ribose Transferases Histocompatibility Antigens. J Mol Biol 1994 Oct 28;243(3):537-46
interleukin-6-PE66(4Glu) chimeric protein, recombinant  0   *Exotoxins *Recombinant Fusion Proteins *Interleukin-6 *ADP Ribose Transferases. Cancer Res 1991;51(11):2831
IL-6-PE40 protein, chimeric  0   *Exotoxins *Recombinant Fusion Proteins *Interleukin-6 *ADP Ribose Transferases Bacterial Proteins. Mol Cell Biol 1990;10(6):2443
exoenzyme C3, Clostridium botulinum  EC 2.4.2.-   *Botulinum Toxins *ADP Ribose Transferases Clostridium botulinum Recombinant Proteins. Biochem Biophys Res Commun 1990;166(3):1398
dinitrogenase reductase ADP-ribosyltransferase  EC 2.4.2.37   *ADP Ribose Transferases Nitrogen Fixation. J Biol Chem 1988;263(32):16714
iota toxin, Clostridium spiroforme  0   *Bacterial Toxins *ADP Ribose Transferases Clostridium Enterotoxins. Vet Microbiol 1987;15(1-2):115
NAD-cysteine ADP-ribosyltransferase  EC 2.4.2.-   *ADP Ribose Transferases. Seikagaku 1987;59(6):361
iota toxin, Clostridium perfringens  0   *Bacterial Toxins *ADP Ribose Transferases Clostridium perfringens Enterotoxins. Toxicon 1986;24(8):767
toxA protein, Pseudomonas aeruginosa  EC 2.4.2.31   *Bacterial Toxins *Exotoxins *Virulence Factors *ADP Ribose Transferases Antineoplastic Agents. Infect Immun 13(5):1467;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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