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Receptor, EphB4

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Definition: An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of proteins in this class there is little or no expression of EphB4 receptor in the BRAIN. It has been found at high levels in developing mammary glands and in invasive mammary tumors.      Other names Transmembrane Kinase, Hepatoma; Kinase, Hepatoma Transmembrane; Hepatoma Transmembrane Kinase; EPHB4 Protein; EphB4 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
XL647  0   *Quinazolines *Azabicyclo Compounds Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors Receptor, EphB4/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Clin Cancer Res. 2007 Jun 15;13(12):3713-23.
1-(1-(2-amino-pyridin-4-ylmethyl)-1H-indol-4-yl)-3-(5-bromo-2-methoxyphenyl)urea  0   *Indoles *Phenylurea Compounds Receptor, EphB4/antagonists & inhibitors. Biomed Chromatogr 2011 Jul;25(7):794-800
Ephb4 protein, mouse  EC 2.7.1.-   *Receptor, EphB4. Oncogene 1994 May;9(5):1461-7; Oncogene 1995 Nov 16;11(10):2085-95

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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