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Intercellular Signaling Peptides and Proteins

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Definition: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.  general or unspecified; prefer specifics; coordinate with PARACRINE COMMUNICATION if pertinent; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS is also available   
See Also Paracrine Communication; Peptide Hormones; Receptors, Growth Factor
Examples Adipokines; Agouti Signaling Protein; Agouti-Related Protein; Angiogenic Proteins; CCN Intercellular Signaling Proteins; Cytokines; Endothelial Growth Factors; Endothelins; Ephrins; Epidermal Growth Factor; Fibroblast Growth Factors; Hedgehog Proteins; Interferons; Kinins; Kisspeptins; Nerve Growth Factors; Parathyroid Hormone-Related Protein; Platelet-Derived Growth Factor; Semaphorins; Somatomedins; Tolloid-Like Metalloproteinases; TGF-beta Superfamily Proteins; Transforming Growth Factors; Tumor Necrosis Factors 		Other names Peptide Factors, Paracrine; Paracrine Protein Factors; Paracrine Peptide Factors; Growth Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gremlin 2 protein, zebrafish  0   *Zebrafish Proteins *Intercellular Signaling Peptides and Proteins Bone Morphogenetic Proteins/antagonists & inhibitors. Development. 2011 Dec;138(23):5147-56
CLE42 protein, Arabidopsis  0   *Arabidopsis Proteins *Intercellular Signaling Peptides and Proteins. Plant Cell Physiol. 2011 Aug;52(8):1354-64.
DLL1 protein, Xenopus  0   *Xenopus Proteins *Intercellular Signaling Peptides and Proteins. Nat Cell Biol. 2011 Jun;13(6):693-9
Dlk2 protein, mouse  0   *Intercellular Signaling Peptides and Proteins. Biochim Biophys Acta. 2011 Jun;1813(6):1153-64
R-spondin2 protein, human  0   *Intercellular Signaling Peptides and Proteins. J Invest Dermatol 2011 Mar;131(3):644-54
tsukushi protein, mouse  0   *Proteoglycans *Intercellular Signaling Peptides and Proteins. Biochem Biophys Res Commun 2010 Nov 26;402(4):813-8
acylation stimulating protein, human  0   *Intercellular Signaling Peptides and Proteins. Int J Circumpolar Health. 2009 Dec;68(5):421-32
acylation stimulating protein, mouse  0   *Intercellular Signaling Peptides and Proteins. J Vet Sci. 2009 Sep;10(3):197-201
Amot protein, rat  0   *Membrane Proteins *Intercellular Signaling Peptides and Proteins. J Physiol. 2009 Aug 15;587(Pt 16):4105-19
ILP3 protein, Drosophila  0   *Drosophila Proteins *Intercellular Signaling Peptides and Proteins Insulin. Fly (Austin). 2007 Mar-Apr;1(2); 113-5
draxin protein, mouse  0   *Intercellular Signaling Peptides and Proteins. Science. 2009 Jan 16;323(5912):388-93
tissue PA-herstatin adenovirus fusion protein  0   *Recombinant Fusion Proteins *Intercellular Signaling Peptides and Proteins. Arthritis Rheum 2008 Oct;58(10):3071-80
apelin-13, Ala(13)  0   *Intercellular Signaling Peptides and Proteins. Endocrinology 2005 Jan;146(1):231-6
dickkopf-1 protein, rat  0   *Intercellular Signaling Peptides and Proteins. J Neurosci 2008 Aug 20;28(34):8430-41
salusin-beta, rat  0   *Intercellular Signaling Peptides and Proteins. J Neuroendocrinol. 2008 Feb;20(2):207-19
chemerin protein, mouse  0   *Chemotactic Factors *Intercellular Signaling Peptides and Proteins. J Biol Chem 2007 Sep 21;282(38):28175-88
Grem1 protein, mouse  0   *Intercellular Signaling Peptides and Proteins. Development 2007 Jul;134(13):2397-405
Wif1 protein, rat  0   *Extracellular Matrix Proteins *Intercellular Signaling Peptides and Proteins.
EGFL9 protein, mouse  0   *Intercellular Signaling Peptides and Proteins. J Mol Biol. 2007 Apr 13;367(5):1270-80
Prdc protein, zebrafish  0   *Zebrafish Proteins *Intercellular Signaling Peptides and Proteins Glycoproteins. Dev Dyn 2006 Oct;235(10):2881-8
MAU2 protein, human  0   *Intercellular Signaling Peptides and Proteins Chromosomal Proteins, Non-Histone. PLoS Biol 2006 Jul;4(8):e242
Sfrp5 protein, zebrafish  0   *Zebrafish Proteins *Intercellular Signaling Peptides and Proteins. Development 2006 Aug;133(16):3191-200
apelin protein, Xenopus  0   *Xenopus Proteins *Intercellular Signaling Peptides and Proteins. Dev Biol 2006 Aug 1;296(1):177-89
Dkk4 protein, mouse  0   *Intercellular Signaling Peptides and Proteins. Proc Natl Acad Sci U S A 2006 Jun 13;103(24):9142-7
DLK1 protein, human  0   *Membrane Proteins *Intercellular Signaling Peptides and Proteins Cell Differentiation Adipocytes.
Dlk1 protein, mouse  0   *Intercellular Signaling Peptides and Proteins.
Dlk1 protein, rat  0   *Membrane Proteins *Intercellular Signaling Peptides and Proteins.
Ogn protein, mouse  0   *Intercellular Signaling Peptides and Proteins.
Ogn protein, rat  0   *Glycoproteins *Intercellular Signaling Peptides and Proteins.
INSL6 protein, human  0   *Intercellular Signaling Peptides and Proteins.
Amot protein, mouse  0   *Microfilament Proteins *Intercellular Signaling Peptides and Proteins. J Cell Biol 2001 Mar 19;152(6):1247-54
progranulin B, zebrafish  0   *Zebrafish Proteins *Intercellular Signaling Peptides and Proteins. BMC Genomics 2005;6:156
progranulin A, zebrafish  0   *Zebrafish Proteins *Intercellular Signaling Peptides and Proteins. BMC Genomics 2005;6:156
hepatoma-derived growth factor-related protein-3, rat  0   *Nerve Tissue Proteins *Intercellular Signaling Peptides and Proteins. BMC Neurosci 2006;7() (dup#2):6
Wnt8a protein, mouse  0   *Intercellular Signaling Peptides and Proteins. Dev Dyn 2005 Jul;233(3):1064-75
BTC protein, human  0   *Intercellular Signaling Peptides and Proteins. Biochem Biophys Res Commun 1993 Feb 15;190(3):1173-9
Spink1 protein, rat  0   *Intercellular Signaling Peptides and Proteins.
Dkk4 protein, rat  0   *Intercellular Signaling Peptides and Proteins. Int J Mol Med 2005 Sep;16(3):477-81
NLRC3 protein, human  0   *Intercellular Signaling Peptides and Proteins. J Biol Chem 2005 May 6;280(18):18375-85
METRN protein, human  0   *Nerve Tissue Proteins *Intercellular Signaling Peptides and Proteins. EMBO J 2004 May 5;23(9):1998-2008
CECR2 protein, mouse  0   *Intercellular Signaling Peptides and Proteins. Hum Mol Genet 2005 Feb 15;14(4):513-24
dkk1 protein, zebrafish  0   *Zebrafish Proteins *Intercellular Signaling Peptides and Proteins.
Dkk1 protein, mouse  0   *Intercellular Signaling Peptides and Proteins.
DKK1 protein, human  0   *Intercellular Signaling Peptides and Proteins.
NENF protein, human  0   *Nerve Tissue Proteins *Intercellular Signaling Peptides and Proteins. J Neurosci Res 2005 Feb 1;79(3):287-94
Sfrp1 protein, rat  0   *Membrane Proteins *Intercellular Signaling Peptides and Proteins. Endocrinology 2005 May;146(5);2415-23
Dkk3 protein, rat  0   *Intercellular Signaling Peptides and Proteins.
DKK3 protein, human  0   *Intercellular Signaling Peptides and Proteins Cell Aging/genetics.
DKK2 protein, human  0   *Intercellular Signaling Peptides and Proteins.
Apln protein, rat  0   *Intercellular Signaling Peptides and Proteins.
pancreatic secretory trypsin inhibitor II, rat  0   *Intercellular Signaling Peptides and Proteins. J Biomed Sci 2004 Jul-Aug;11(4):528-30
CXXC10 protein, human  0   *Intercellular Signaling Peptides and Proteins. Int J Oncol 2004 Oct;25(4);1193-9
apelin-12 peptide  0   *Intercellular Signaling Peptides and Proteins. Endocrinology 2005 Jan;146(1):231-6
apelin-13 peptide  0   *Intercellular Signaling Peptides and Proteins Ligands. Endocrinology 2005 Jan;146(1):231-6
DAND5 protein, human  0   *Intercellular Signaling Peptides and Proteins. Oncol Rep 2004 Aug;12(2);423-7
GREM2 protein, human  0   *Intercellular Signaling Peptides and Proteins. Oncol Rep 2004 Aug;12(2);423-7
nephroblastoma overexpressed protein, rat  0   *Immediate-Early Proteins *Intercellular Signaling Peptides and Proteins. Biochem Pharmacol. 2004 Oct 1;68(7):1391-400
GRN protein, human  0   *Intercellular Signaling Peptides and Proteins Protein Precursors.
RFNG protein, human  EC 2.4.1.222   *Glucosyltransferases *Intercellular Signaling Peptides and Proteins.
CFC1 protein, human  0   *Intercellular Signaling Peptides and Proteins.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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