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Galectins

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Definition: A class of animal lectins that bind specifically to beta-galactoside in a calcium-independent manner. Members of this class are distiguished from other lectins by the presence of a conserved carbohydrate recognition domain. The majority of proteins in this class bind to sugar molecules in a sulfhydryl-dependent manner and are often referred to as S-type lectins, however this property is not required for membership in this class.  GALECTIN 1 through GALECTIN 4 are available   
Examples Galectin 1; Galectin 2; Galectin 3; Galectin 4 		Other names beta Galactoside Binding Lectin; beta D Galactosyl Specific Lectin; S Type Lectins; S Type Lectin; Lectin, beta-Galactoside Binding; Lectin, beta-D-Galactosyl-Specific; Lectin, S-Type; Lectin, Galactose-Binding; Lectins, S Type; Lectin, D-Galactoside-Binding; Galactose Binding Lectin; D Galactoside Binding Lectin; Binding Lectin, beta-Galactoside; beta-Galactoside Binding Lectin; beta-D-Galactosyl-Specific Lectin; beta-D-Gal(1-3)D-GalNAc Specific Lectins; S-Type Lectins; S-Type Lectin; Galectin; Galactose-Binding Lectin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
frutalin  0   *Galectins Antineoplastic Agents. J Biomed Biotechnol. 2011;2011() (dup#59):568932
LEC-8 protein, C elegans  0   *Caenorhabditis elegans Proteins *Galectins. J Biol Chem 2009 Sep 25;284(39):26493-501
EW29 lectin, Lumbricus terrestris  0   *Galectins. Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):49-57
Gal1-L2 protein, zebrafish  0   *Zebrafish Proteins *Galectins. Glycoconjug J 2009 Apr;26(3):277-83
LEC-6 protein, C elegans  0   *Galectins *Caenorhabditis elegans Proteins. Glycobiology 2008 Nov;18(11):882-90
GRIFIN protein, zebrafish  0   *Zebrafish Proteins *Galectins. Biochem Biophys Res Commun 2008 Jul 4;371(3):350-5
galectin-VIa protein, Xenopus  0   *Xenopus Proteins *Galectins. Gene Expr Patterns 2007 Oct;7(8):852-7
galectin-8, mouse  0   *Galectins. Glycobiology 2007 Dec;17(12):1404-12
Lec-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Galectins. Biol Pharm Bull 2007 Nov;30(11):2012-7
galectin 10, human  0   *Galectins. Blood 2007 Sep 1;110(5):1550-8
galectin 15, mouse  0   *Galectins. Biol Reprod 2006 Aug;75(2):289-96
galectin 9, rat  0   *Galectins. Int J Biochem Cell Biol 2006;38(10):1741-58
CVL galactose-specific lectin, Chaetopterus variopedatus  0   *Galectins. J Clin Pediatr Dent 2005 Winter;30(2):115-9
galectin 9, mouse  0   *Galectins. J Am Soc Nephrol 2005 Nov;16(11):3222-34
Lgals12 protein, mouse  0   *Cell Cycle Proteins *Galectins.
LGALS12 protein, human  0   *Cell Cycle Proteins *Galectins.
Lgals7 protein, rat  0   *Galectins.
Lgals7 protein, mouse  0   *Galectins.
Grifin protein, mouse  0   *Eye Proteins *Galectins.
galectin 12, human  0   *Galectins. Cell Mol Life Sci 2003 Feb;60(2):267-76
Galig protein, human  0   *Blood Proteins *Galectins. J Biol Chem 2001 Jan 26;276(4):2652-7
congerin II protein, Conger eel  0   *Galectins Eels. Comp Biochem Physiol B Biochem Mol Biol 1999 May;123(1):33- 45
GRIFIN protein, rat  0   *Eye Proteins *Galectins. J Biol Chem 1998 Oct 30;273(44):28889-96
Lgals6 protein, mouse  0   *Galectins. J Biol Chem 1998 Jan 30;273(5):2961-70
LGALS9 protein, human  0   *Galectins. J Biol Chem 1997 Mar 7;272(10):6416-22
CGL1 protein, Coprinus cinereus  0   *Fungal Proteins *Galectins. J Biol Chem 1997 Jan 17;272(3):1514-21
LGALS7 protein, human  0   *Galectins. J Biol Chem 1995 Mar 17;270(11):5823-9
galectin 5  0   *Galectins. J Biol Chem 1995 Mar 10;270(10):5032-8
LGALS8 protein, human  0   *Galectins Antigens, Neoplasm. J Biol Chem 1995 Feb 17;270(7):3447-53
lectin-1, Geodia cydonium  0   *Galectins Porifera. Glycobiology 1993 Apr;3(2):179-84
congerin protein, Conger myriaster  147096-61-5   *Galectins Eels. Biochim Biophys Acta 1992 Apr 22;1116(2):129-36
LGALS13 protein, human  0   *Pregnancy Proteins *Galectins. Oncodev Biol Med 1983;4(5):343; Protein Eng 2001;14(11):875

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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