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Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Definition: A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.     
See Also Sirtuins 		Other names Silent Mating Type Information Regulator Protein, ; Silent Information Regulator Proteins, S cerevisia; SIR Proteins, S cerevisiae
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SIR2 protein, S cerevisiae  EC 3.5.1.-   *Silent Information Regulator Proteins, Saccharomyces cerevisiae *Sirtuin 2. Mol Cell Biol 1994 Jul;14(7):4501-8
SIR3 protein, S cerevisiae  0   *Silent Information Regulator Proteins, Saccharomyces cerevisiae. Cell 1993 Nov 5;75(3):543-55
SIR1 protein, S cerevisiae  0   *Silent Information Regulator Proteins, Saccharomyces cerevisiae. Cell 1993 Nov 5;75(3):531-41
SIR4 protein, S cerevisiae  0   *Silent Information Regulator Proteins, Saccharomyces cerevisiae. Nature 1989;342(6245):24

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