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Polypyrimidine Tract-Binding Protein

More information in Books or onNLM PubMed
Definition: A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.      Other names p57 Cytoplasmic RNA Binding Protein; Tract-Binding Protein, Polypyrimidine; Splicing Factor, PTB; Polypyrimidine Tract Binding Protein; p57 Cytoplasmic RNA-Binding Protein; PTB Splicing Factor; pPTB; PTB Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PTBP2 protein, human  0   *Nerve Tissue Proteins *Polypyrimidine Tract-Binding Protein. Mol Cell Biol 2000 Oct;20(20):7463-79
PTBP2 protein, rat  0   *Nerve Tissue Proteins *Polypyrimidine Tract-Binding Protein. Genomics 2004 Jan;83(1):76-84
PTBP1 protein, human  0   *Heterogeneous-Nuclear Ribonucleoproteins *Polypyrimidine Tract-Binding Protein.
hnRNP I-related RNA transport protein VgRBP60, Xenopus  0   *Xenopus Proteins *Polypyrimidine Tract-Binding Protein.
Ptbp2 protein, mouse  0   *Nerve Tissue Proteins *Polypyrimidine Tract-Binding Protein. Proc Natl Acad Sci U S A 2000 Jun 6;97(12):6350-5
PTBP3 protein, human  0   *Polypyrimidine Tract-Binding Protein. Mol Cell Biol 1999 May;19(5):3829-41
PTB-associated splicing factor  0   *RNA-Binding Proteins RNA Splicing Polypyrimidine Tract-Binding Protein. Genes Dev 1993 Mar;7(3):393-406

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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