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Integrin alpha Chains

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Definition: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.     
Examples Antigens, CD11a; Antigens, CD11b; Antigens, CD11c; Integrin alpha1; Integrin alpha2; Integrin alpha3; Integrin alpha4; Integrin alpha5; Integrin alpha6; Integrin alphaV; Platelet Membrane Glycoprotein IIb 		Other names alpha Chains, Integrin; Integrins, alpha; Integrin alpha Subunits; alpha Integrins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ITGA11 protein, rat  0   *Integrin alpha Chains. Reprod Sci 2011 Feb;18(2):156-63
integrin alphaD, mouse  0   *Antigens, CD11 *Integrin alpha Chains Protein Subunits. J Immunol 2008 Jan 1;180(1):590-600
integrin alphaHr1, Halocynthia roretzi  0   *Integrin alpha Chains. J Immunol 2001 Feb 1;166(3):1710-5
Integrin alphaP, Strongylocentrotus purpuratus  0   *Integrin alpha Chains. Biochem Biophys Res Commun 2000 Jun 16;272(3):929-35
ITGAD protein, human  0   *Antigens, CD11 *Integrin alpha Chains. J Biol Chem 2000 Mar 24;275(12):8959-69
integrin alpha 10  0   *Integrin alpha Chains. Cytogenet Cell Genet 1999 ;87(3-4):238-44
ITGA11 protein, human  0   *Integrin alpha Chains. J Biol Chem 1999 Sep 3;274(36):25735-42
integrin alpha8  0   *Integrin alpha Chains. J Cell Sci 1995 Feb;108( Pt 2):537-44
alpha E integrins  0   *Antigens, CD *Integrin alpha Chains. J Biol Chem 1994 Feb 25;269(8):6016-25
integrin alpha7  0   *Antigens, CD *Integrin alpha Chains Biological Markers. Exp Cell Res 1994 Feb;210(2):278-86
integrin alpha9  0   *Integrin alpha Chains. J Cell Biol 1993 Dec;123(5):1289-97
if protein, Drosophila  0   *Drosophila Proteins *Integrin alpha Chains. Biochem Biophys Res Commun 1993 Jul 15;194(1):490-5
CDw49d  0   *Integrin alpha Chains Receptors, Very Late Antigen. J Immunol 1990;144(3):777

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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