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Integrin alpha4

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Definition: An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.      Other names Integrin, alpha4; Antigen, CD49d; alpha4 Integrin; CD49d Antigen; CD49d Antigens; Antigens, CD49d
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
natalizumab  0   *Antibodies, Monoclonal, Humanized Cell Migration Inhibition Multiple Sclerosis Integrin alpha4. Nervenarzt 2002 Jun;73(6):552-5TYSABRI

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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