Definition: A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Other names Non-Sedating H1 Antihistamines; Histamine H1 Antagonists, Non Sedating; H1 Antihistamines, Non Sedating; Antihistamines, Second Generation; Third Generation H1 Antagonists; Second Generation H1 Antagonists; Second Generation Antihistamines; H1 Antihistamines, Non-Sedating
