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Eukaryotic Initiation Factor-4A

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Definition: A component of eukaryotic initiation factor 4F that as an RNA helicase involved in unwinding the secondary structure of the 5' UNTRANSLATED REGION of MRNA. The unwinding facilitates the binding of the 40S ribosomal subunit.      Other names Eukaryotic Initiation Factor 4A3; Eukaryotic Initiation Factor 4A2; Eukaryotic Initiation Factor 4A1; Eukaryotic Initiation Factor 4A; Eukaryotic Translation-Initiation Factor 4AIII; Eukaryotic Peptide Initiation Factor-4A; Eukaryotic Initiation Factor-4A3; Eukaryotic Initiation Factor-4A2; Eukaryotic Initiation Factor-4A1; Eukaryotic Initiation Factor EIF-4A; EIF4AIII; EIF-4A3; EIF-4A2; EIF-4A1; Peptide Initiation Factor EIF 4A; Initiation Factor-4A3, Eukaryotic; Initiation Factor-4A2, Eukaryotic; Initiation Factor-4A1, Eukaryotic; Initiation Factor-4A, Eukaryotic; Factor-4A3, Eukaryotic Initiation
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BPSL1549 protein, Burkholderia pseudomallei  0   *Bacterial Proteins *Bacterial Toxins Cytotoxins Eukaryotic Initiation Factor-4A/antagonists & inhibitors. Science. 2011 Nov 11;334(6057):821-4
pateamine A  0   *Epoxy Compounds *Thiazoles *Macrolides Eukaryotic Initiation Factor-4A. Ernst Schering Res Found Workshop 2000 ;(32):103-48

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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