Definition: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Other names Nerve Growth Factor Inducible Large External Glyco; NGF Inducible Glycoprotein; Glycoprotein, NILE; Glycoprotein, NGF-Inducible; Neural Adhesion Molecule L1; Nerve Growth Factor-Inducible Large External Glyco; NILE Protein; NILE Glycoprotein; NGF-Inducible Glycoprotein; L1CAM; L1 Cell Adhesion Molecule; F11 Glycoprotein; Cell Surface Glycoprotein L1; Cell Adhesion Molecule L1; CamL1 Gene Product; CALL Protein
