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Receptors, Vascular Endothelial Growth Factor

More information in Books or onNLM PubMed
Definition: A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.  GEN; prefer specifics, DF: VEGF RECEPT   
Examples Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3 		Other names Receptors, VEGF; Vascular Permeability Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Cell Growth Factor Receptor; VEGF Receptors; VEGF Receptor; VPF Receptor; Receptor, Vascular Permeability Factor; Receptor, Vascular Endothelial Cell Growth Factor; Receptor, Endothelial Growth Factors; Endothelial Growth Factor Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DEspR protein, rat  0   *Receptors, Vascular Endothelial Growth Factor *Receptor, Endothelin A. Mol Imaging Biol. 2011 Dec;13(6):1096-106.
PF 00337210  0   *Benzofurans *Quinolines Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. AAPS PharmSciTech 2011 Mar;12(1):362-71
TAK 593  0   *Pyrazoles *Azabicyclo Compounds Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Biochemistry 2011 Feb 8;50(5):738-51
farnesiferol C  0   *Coumarins Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Mol Cancer Ther 2010 Feb;9(2):389-99
tivozanib  0   *Phenylurea Compounds *Quinolines Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. IDrugs 2010 Sep;13(9):636-45
GSK 1363089  0   *Anilides *Quinolines Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Cancer Res 2009 Sep 1;69(17):6871-8
N-(2-chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)urea  0   *Isoxazoles *Phenylurea Compounds Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Cancer Res 2006 Sep 15;66(18):9134-42
4-(2-(5-cyanothiazol-2-ylamino)pyridin-4-ylmethyl)piperazine-1-carboxylic acid methylamide  0   *Aminopyridines *Thiazoles Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. J Med Chem 2004 Dec 2;47(25):6363-72
BSF 476921  0   *Organic Chemicals Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Restor Neurol Neurosci 2004;22(2):73-9
AEE 788  0   *Purines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Cancer Res 2004 Jul 15;64(14):4931-41
GW 654652  0   *Imidazoles *Pyrimidines Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Blood 2004 May 1;103(9):3474-9
3-(5-methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid  0   *Indoles *Propionic Acids Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Sep;306(3):838-45
VEGF-Trap fusion protein, recombinant  0   *Recombinant Fusion Proteins *Receptors, Vascular Endothelial Growth Factor. Proc Natl Acad Sci U S A 2002 Aug 20;99(17):11393-8
sorafenib  0   *Benzenesulfonates *Pyridines Receptors, Vascular Endothelial Growth Factor raf Kinases.
Pharma Action Antineoplastic Agents ; Protein Kinase Inhibitors 		Curr Pharm Des 2002;8(25):2249-53NEXAVAR
Pvr protein, Drosophila  EC 2.7.1.112   *Receptor Protein-Tyrosine Kinases *Drosophila Proteins Receptors, Platelet-Derived Growth Factor Receptors, Vascular Endothelial Growth Factor. Cell 2001 Oct 5;107(1):17-26

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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