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Vascular Endothelial Growth Factor Receptor-1

More information in Books or onNLM PubMed
Definition: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.      Other names Vascular Endothelial Growth Factor Receptor 1; VEGF Receptor flt 1 Protein; Tyrosine Kinase, fms-Like; Receptor, FLT VEGF; Proto Oncogene Protein flt; FLT VEGF Receptor; fms-Like Tyrosine Kinase; VEGF Receptor, FLT; VEGF Receptor flt-1 Protein; Proto-Oncogene Protein flt; FLT1 Receptor Tyrosine Kinase; FLT1 RTK; VEGFR-1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Flt(1-3)-IgG  0   *Immunoglobulin G *Recombinant Fusion Proteins *Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor A/antagonists & inhibitors. Nat Med 1999 Jun;5(6):623-8
3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one  0   *Indoles Vascular Endothelial Growth Factor Receptor-1/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. J Cell Physiol 2010 Jul;224(1):262-72
Flt1 protein, rat  EC 2.7.1.112   *Vascular Endothelial Growth Factor Receptor-1.
Flt1 protein, mouse  EC 2.7.1.112   *Vascular Endothelial Growth Factor Receptor-1.
FLT1 protein, human  EC 2.7.10.1   *Vascular Endothelial Growth Factor Receptor-1.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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