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Vascular Endothelial Growth Factor A

More information in Books or onNLM PubMed
Definition: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.      Other names VEGF; Permeability Factor, Vascular; Glioma Derived Vascular Endothelial Cell Growth Fa; Vasculotropin; Vascular Permeability Factor; VEGF-A; Glioma-Derived Vascular Endothelial Cell Growth Fa; GD-VEGF; Vascular Endothelial Growth Factor-A; Vascular Endothelial Growth Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Flt(1-3)-IgG  0   *Immunoglobulin G *Recombinant Fusion Proteins *Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor A/antagonists & inhibitors. Nat Med 1999 Jun;5(6):623-8
FP3 VEGF receptor Fc-fusion protein  0   *Recombinant Fusion Proteins Vascular Endothelial Growth Factor A/antagonists & inhibitors. Cancer Immunol Immunother 2010 Feb;59(2):239-46
64Cu-DOTA-VEGF(DEE)  0   *Organometallic Compounds *Vascular Endothelial Growth Factor A Copper Radioisotopes. Eur J Nucl Med Mol Imaging 2007 Dec;34(12):2001-10
technetium 99m HYNIC-vascular endothelial growth factor  0   *Vascular Endothelial Growth Factor A. Eur J Nucl Med Mol Imaging 2006 Jul;33(7):841-8
vammin protein, Vipera ammodytes ammodytes  0   *Viper Venoms *Vascular Endothelial Growth Factor A. J Biol Chem 2003 Dec 26;278(52):51985-8
vascular endothelial growth factor A (138-165)  0   *Peptide Fragments *Vascular Endothelial Growth Factor A Neuropilin-1/antagonists & inhibitors. J Biol Chem 2006 May 12;281(19):13493-502
arginyl-arginyl-lysyl-arginyl-arginyl-arginine  0   *Oligopeptides Vascular Endothelial Growth Factor A/antagonists & inhibitors. J Biol Chem 2000 May 5;275(18):13588-96
pegaptanib  0   *Aptamers, Nucleotide Vascular Endothelial Growth Factor A. N Engl J Med 2004 Dec 30;351(27):2805-16MACUGEN
bevacizumab  0   *Antibodies, Monoclonal, Humanized Vascular Endothelial Growth Factor A.
Pharma Action Angiogenesis Inhibitors
Curr Oncol Rep 2002 Sep;4(5):369-74AVASTIN
vascular endothelial growth factor A, rat  0   *Vascular Endothelial Growth Factor A.
VEGFA protein, human  0   *Vascular Endothelial Growth Factor A.
vascular endothelial growth factor A, mouse  0   *Vascular Endothelial Growth Factor A.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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