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11-beta-Hydroxysteroid Dehydrogenases

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Definition: Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.     
Examples 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2 		Other names beta-Hydroxysteroid Dehydrogenase, 11; Dehydrogenases, 11-beta-Hydroxysteroid; Dehydrogenase, 11beta-Hydroxysteroid; Dehydrogenase, 11B-Hydroxysteroid; Dehydrogenase, 11-Hydroxysteroid; Dehydrogenase, 11 beta-Hydroxysteroid; Cortisone 11 Oxoreductase; Corticosteroid 11 Reductase; Corticosteroid 11 Oxidoreductase; 11beta Hydroxysteroid Dehydrogenase; 11B Hydroxysteroid Dehydrogenase; 11-Reductase, Corticosteroid; 11-Oxoreductase, Cortisone; 11-Oxidoreductase, Corticosteroid; 11 beta Hydroxysteroid Dehydrogenases; 11 beta Hydroxysteroid Dehydrogenase; 11 Hydroxysteroid Dehydrogenase; Cortisone 11-Oxoreductase; Corticosteroid 11-Reductase; Corticosteroid 11-Oxidoreductase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-eicosahydro-5,5,7a,7b,9a,12,15b-heptamethyl-3,15-dioxo-N-hydroxy-N-methyl-1H-chryseno(2,1-c)azepine-12-carboxylic acid amide  0   *Azepines Glycyrrhetinic Acid/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):1866-80
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone  0   *Cyclic S-Oxides *Thiazines 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Biochem Pharmacol 2011 Apr 15;81(8):1028-35
massarinolin C  0   *Sesquiterpenes 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Phytochemistry. 2010 Jan;71(1):100-3
craterellin B  0   *Sesquiterpenes 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Phytochemistry. 2010 Jan;71(1):100-3
craterellin C  0   *Sesquiterpenes 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Phytochemistry. 2010 Jan;71(1):100-3
craterellin A  0   *Sesquiterpenes 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Phytochemistry. 2010 Jan;71(1):100-3
PF 877423  0   *Pyrrolidines Adamantane/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Bioorg Med Chem Lett 2010 May 1;20(9):2897-902
Cortisone reductase deficiency  0   *Hirsutism/congenital *Steroid Metabolism, Inborn Errors *46, XX Disorders of Sex Development 11-beta-Hydroxysteroid Dehydrogenases/deficiency.
HSD1 protein, Arabidopsis  EC 1.1.1.146   *Arabidopsis Proteins *11-beta-Hydroxysteroid Dehydrogenases. Plant Physiol 2007 Sep;145(1):87-97
4-propyl-N-(2-thiophen-2-ylethyl)benzenesulfonamide  0   *Sulfonamides *Thiophenes 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9
3-chloro-2-methyl-N-(9-oxo-9H-fluoren-3-yl)benzenesulfonamide  0   *Fluorenes *Sulfonamides 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9
3,5-dichloro-N-(2-methylbenzothiazol-5-yl)benzamide  0   *Benzamides *Benzimidazoles 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9
BVT.14225  0   *Sulfonamides *Thiazoles 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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