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Electron Transport Complex I

More information in Books or onNLM PubMed
Definition: A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.      Other names Ubiquinone Reductase; Respiratory Complex I; NADH-Ubiquinone Reductase; NADH-Ubiquinone Oxidoreductase; NADH-Coenzyme Q Reductase; NADH-CoQ Reductase; NADH Q1 Oxidoreductase; NADH Dehydrogenase I; NADH Dehydrogenase Complex 1; Complex I Dehydrogenase; NADH DH I; Rotenone Sensitive Mitochondrial NADH Ubiquinone O; Reductase, NADH-Ubiquinone; Oxidoreductase, NADH-Ubiquinone; Oxidoreductase, NADH Q1; NADH Ubiquinone Reductase; NADH Ubiquinone Oxidoreductase; NADH Coenzyme Q Reductase; NADH CoQ Reductase; Dehydrogenase, Complex I
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NDUFA4L2 protein, mouse  EC 1.5.6.3   *Electron Transport Complex I Protein Subunits Mitochondrial Proteins. Cell Metab. 2011 Dec 7;14(6):768-79.
NDUFA9 protein, human  EC 1.6.5.3   *Electron Transport Complex I Protein Subunits. J Med Genet. 2012 Jan;49(1): 10-5
NuoG protein, E coli  EC 1.6.99.3.   *Escherichia coli Proteins *Electron Transport Complex I. Biochim Biophys Acta. 2010 Dec;1797(12):1894-900
NuoE protein, E coli  EC 1.6.99.3.   *Escherichia coli Proteins *Electron Transport Complex I. Biochim Biophys Acta. 2010 Dec;1797(12):1894-900
NDUFS4 protein, Arabidopsis  EC 1.6.5.3   *Arabidopsis Proteins *Electron Transport Complex I. J Biol Chem 2009 Nov 20;284(47):603-19
NuoH protein, E coli  EC 1.6.5.3   *Membrane Proteins *Escherichia coli Proteins Protein Subunits Electron Transport Complex I. J Biol Chem 2009 Apr 10;284(15):9814-23
Mitochondrial complex I deficiency  0   *Mitochondrial Diseases Electron Transport Complex I/deficiency.
Ndufs4 protein, mouse  0   *Electron Transport Complex I. Methods 2008 Dec;46(4):241-7
NDUFAB1 protein, human  EC 1.6.5.3   *Electron Transport Complex I. BMC Cell Biol 2008;9:8
NDUFA11 protein, human  0   *Electron Transport Complex I. Ann Neurol. 2008 Mar;63(3):405-8
2-(4-(4-fluorobutyl)benzylsulfanyl)-3-methylchromen-4-one  0   *Chromones *Sulfides Electron Transport Complex I/antagonists & inhibitors. J Med Chem 2007 Sep 6;50(18):4304-15
Ndufb11 protein, mouse  EC 1.6.5.3   *Nerve Tissue Proteins *Electron Transport Complex I Nerve Tissue Proteins Protein Subunits Mitochondrial Proteins. Gene Expr Patterns 2007 Jan;7(3):370-4
NDUFB11 protein, human  EC 1.6.5.3   *Electron Transport Complex I Protein Subunits. Biochem Biophys Res Commun 2007 Mar 30;355(1):181-7
NAD4 protein, Arabidopsis  EC 1.6.99.3   *Arabidopsis Proteins *Electron Transport Complex I Protein Subunits. Curr Genet 2001 Oct;40(3):214-9
circumdatin H  0   *Benzodiazepinones Electron Transport Complex I/antagonists & inhibitors. J Antibiot (Tokyo) 2005 Jun;58(6):416-9
Ndi1 protein, S cerevisiae  EC 1.6.5.3   *Saccharomyces cerevisiae Proteins *Electron Transport Complex I. Hum Gene Ther 2004 Sep;15(9):887-95
NUO-1 protein, C elegans  EC 1.6.5.3   *Electron Transport Complex I. Biochem Biophys Res Commun 2004 Jul 9;319(4):1307-13
ajudazol B  0   *Coumarins Electron Transport Complex I/antagonists & inhibitors. J Antibiot (Tokyo) 2004 Feb;57(2):151-5
ajudazol A  0   *Coumarins Electron Transport Complex I/antagonists & inhibitors. J Antibiot (Tokyo) 2004 Feb;57(2):151-5
ND5 protein, human  EC 1.6.99.3   *Mitochondrial Proteins *Electron Transport Complex I Protein Subunits. Neurology 2003 Jun 10;60(11):1857-61
NuoB protein, E coli  EC 1.6.99.3   *Escherichia coli Proteins *Electron Transport Complex I Protein Subunits. J Biol Chem 2003 Nov 28;278(48):47602-9
fenpyroximate  134098-61-6   *Benzoates *Pyrazoles Electron Transport Complex I/antagonists & inhibitors. J Chromatogr A 2000 Jun 2;880(1-2):121-8
MT-ND3 protein, human  EC 1.6.5.3   *Electron Transport Complex I. Genetics 1998 Sep;150(1):359-68

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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