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Glutamate Carboxypeptidase II

More information in Books or onNLM PubMed
Definition: A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8.      Other names Peptidase, N-Acetylaspartylglutamate; N Acetylated alpha Linked Acidic Dipeptidase; N Acetylaspartylglutamate Peptidase; Hydrolase I, Folate; Dipeptidase, N-Acetylated-alpha-Linked Acidic; Carboxypeptidase II, Glutamate; Acidic Dipeptidase, N-Acetylated-alpha-Linked; NAALADase L; NAALADase II; NAALADase; NAAG Peptidase; N-Acetylated-alpha-Linked Acidic Dipeptidase; N-Acetylaspartylglutamate Peptidase; Folate Hydrolase I; FOLH1 Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-((1-carboxy-4-mercaptobutyl)thio)benzoic acid  0   *Benzoic Acids *Sulfhydryl Compounds Glutamate Carboxypeptidase II/antagonists & inhibitors. J Med Chem 2006 May 18;49(10):2876-85
3-(1-carboxy-4-mercaptobutoxy)benzoic acid  0   *Sulfhydryl Compounds *Benzoic Acids Glutamate Carboxypeptidase II/antagonists & inhibitors. J Med Chem 2006 May 18;49(10):2876-85
2-(hydroxypentafluorophenylmethylphosphinoylmethyl)pentanedioic acid  0   *Glutarates *Phosphinic Acids Glutamate Carboxypeptidase II/antagonists & inhibitors. J Med Chem 2005 Apr 7;48(7):2319-24
Glutamate carboxypeptidase III, mouse  EC 3.4.17.21   *Glutamate Carboxypeptidase II. J Neurochem. 2004 May;89(3) :627-35
2-(3-(1-carboxy-2-(4-hydroxyphenyl)ethyl)ureido)pentanedioic acid  0   *Glutamates Urea/*analogs & derivatives Glutamate Carboxypeptidase II/antagonists & inhibitors. J Med Chem 2004 Mar 25;47(7):1729-38
glutamate carboxypeptidase II, human  EC 3.4.17.21   *Antigens, Surface *Glutamate Carboxypeptidase II.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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