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Proprotein Convertases

More information in Books or onNLM PubMed
Definition: Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.     
Examples Carboxypeptidase H; Carboxypeptidase U; Furin; Proprotein Convertase 1; Proprotein Convertase 2; Proprotein Convertase 5; Renin 		Other names Subtilisin Like Proprotein Convertases; Proprotein Convertases, Subtilisin-Like; Pro Opiomelanocortin Converting Enzyme; Pro Opiocortin Converting Protease; Pro Opiocortin Converting Enzyme; POMC Converting Enzyme; Converting Protease, Pro-Opiocortin; Converting Enzyme, Pro-Opiomelanocortin; Converting Enzyme, Pro-Opiocortin; Convertases, Subtilisin-Like Proprotein; Convertases, Proprotein; Convertases, Prohormone; Convertase, Proprotein; Convertase, Proopiomelanocortin; Convertase, Prohormone; Convertase, POMC; Subtilisin-Like Proprotein Convertases; Proopiomelanocortin Convertase; Prohormone Convertase; Pro-Opiocortin Converting Protease
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
FurinA protein, zebrafish  EC 3.4.-   *Zebrafish Proteins *Proprotein Convertases. PLoS Genet 2010;6(4):e1000907
Pcsk6 protein, rat  EC 3.4.21.-   *Proprotein Convertases.
Pcsk6 protein, mouse  EC 3.4.21.-   *Proprotein Convertases.
PCSK4 protein, human  EC 3.4.21.-   *Subtilisins *Proprotein Convertases.
PCSK9 protein, human  EC 3.4.21.-   *Serine Endopeptidases *Proprotein Convertases Apoptosis. Proc Natl Acad Sci U S A 2003 Feb 4;100(3):928-33
membrane-bound transcription factor peptidase, site 1  EC 3.4.21.112   *Serine Endopeptidases *Proprotein Convertases. Mol Cell 1998 Oct;2(4):505-14
RCE1 protein, S cerevisiae  EC 3.4.24.-   *Metalloendopeptidases *Saccharomyces cerevisiae Proteins *Proprotein Convertases. Genomics 1999 Jun 15;58(3):270-80; Science 1997 Mar 21;275(5307):1796-800
PCSK6 protein, human  EC 3.4.21.-   *Serine Endopeptidases *Proprotein Convertases Isoenzymes. J Biochem (Tokyo) 1993 Feb;113(2):132-5
photosystem II, D1 polypeptide carboxy-terminal processing protease  EC 3.4.99.-   *Carboxypeptidases *Proprotein Convertases. J Biol Chem 1992 Mar 15;267(8):5424-33
KEX2 protein, S cerevisiae  EC 3.4.21.61   *Saccharomyces cerevisiae Proteins *Proprotein Convertases. FEBS Lett 1987;218(1):31; FEBS Lett 1988;229(1):167; Proc Natl Acad Sci USA 1989;86(5):1434

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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