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Receptors, G-Protein-Coupled

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Definition: The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS.  GEN or unspecified; prefer specifics   
Examples Calcitonin Receptor-Like Protein; Frizzled Receptors; Receptor, Anaphylatoxin C5a; Receptor, PAR-2; Receptors, Adrenomedullin; Receptors, Angiotensin; Receptors, Bombesin; Receptors, Bradykinin; Receptors, Calcitonin; Receptors, Calcitonin Gene-Related Peptide; Receptors, Calcium-Sensing; Receptors, Cannabinoid; Receptors, Catecholamine; Receptors, Chemokine; Receptors, Cholecystokinin; Receptors, Corticotropin-Releasing Hormone; Receptors, Eicosanoid; Receptors, Endothelin; Receptors, Formyl Peptide; Receptors, FSH; Receptors, GABA-B; Receptors, Galanin; Receptors, Ghrelin; Receptors, Glucagon; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Islet Amyloid Polypeptide; Receptors, LH; Receptors, LHRH; Receptors, Lysophospholipid; Receptors, Melanocortin; Receptors, Melatonin; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, Neuropeptide Y; Receptors, Neurotensin; Receptors, Odorant; Receptors, Opioid; Receptors, Oxytocin; Receptors, Parathyroid Hormone; Receptors, Pheromone; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Purinergic; Receptors, Serotonin; Receptors, Somatostatin; Receptors, Thrombin; Receptors, Vasoactive Intestinal Peptide; Receptors, Vasopressin; Rhodopsin 		Other names Receptors, G Protein Coupled; G Protein Coupled Receptors; G-Protein-Coupled Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GPR18 protein, mouse  0   *Receptors, G-Protein-Coupled. Mamm Genome. 1996 Dec;7(12):920-1.
CG4395 protein, Drosophila  0   *Drosophila Proteins *Receptors, G-Protein-Coupled. PLoS One. 2011;6(11):e28369.
GPR21 protein, mouse  0   *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun. 2012 Feb 3;418(1):1-5.
Cand7 protein, Arabidopsis  0   *Arabidopsis Proteins *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun. 2012 Jan 20;417(3):991-5.
Cand2 protein, Arabidopsis  0   *Arabidopsis Proteins *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun. 2012 Jan 20;417(3):991-5.
MrgF protein, mouse  0   *Receptors, G-Protein-Coupled. Mol Pain. 2008 Jan 15;4:2.
GPR133 protein, mouse  0   *Cell Adhesion Molecules *Receptors, G-Protein-Coupled. J Biol Chem. 2011 Dec 9;286(49):41912-6.
Gpr153 protein, human  0   *Receptors, G-Protein-Coupled. Biochim Biophys Acta. 2005 Apr 15;1722(3):235-46.
Gpr162 protein, human  0   *Receptors, G-Protein-Coupled. Biochim Biophys Acta. 2005 Apr 15;1722(3):235-46.
dihydrocaffeic acid receptor 1, C elegans  0   *Caenorhabditis elegans Proteins *Receptors, G-Protein-Coupled. J Neurosci. 2011 Nov 16;31(46):16603-10
STR-33 protein, C elegans  0   *Caenorhabditis elegans Proteins *Receptors, G-Protein-Coupled. J Biol Chem. 2011 Nov 18;286(46):39860-70
Lgr6 protein, zebrafish  0   *Zebrafish Proteins *Receptors, G-Protein-Coupled. Gene Expr Patterns. 2011 Oct;11(7):378-83.
Lgr4 protein, zebrafish  0   *Receptors, G-Protein-Coupled. Gene Expr Patterns. 2011 Oct;11(7):378-83.
GPR55 protein, rat  0   *Receptors, G-Protein-Coupled *Receptors, Cannabinoid. Br J Pharmacol. 2007 Dec;152(7):1092-101.
GPR172B protein, human  0   *Membrane Transport Proteins *Receptors, G-Protein-Coupled. Hum Mutat. 2011 Jan;32(1):E1976-84.
TAS2R1 protein, human  0   *Receptors, G-Protein-Coupled Taste. J Recept Signal Transduct Res. 2011 Jun;31(3):229-40.
GPR61 protein, mouse  0   *Receptors, G-Protein-Coupled. Life Sci. 2011 Nov 21;89(21-22):765-72
CG34381 protein, Drosophila  0   *Drosophila Proteins *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun. 2011 Oct 14;414(1):44-8.
RXFP4 protein, mouse  0   *Receptors, G-Protein-Coupled. Biochemistry. 2011 Oct 4;50(39):8352-61.
GPRC5C protein, mouse  0   *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun 2011 Sep 2;412(3):460-5
Tas2R108 protein, mouse  0   *Receptors, G-Protein-Coupled. Proc Natl Acad Sci U S A 2011 Jun 7;108(23):9478-83
Tas2R105 protein, mouse  0   *Receptors, G-Protein-Coupled. Proc Natl Acad Sci U S A 2011 Jun 7;108(23):9478-83
Rxfp1 protein, zebrafish  0   *Zebrafish Proteins *Receptors, G-Protein-Coupled Receptors, Peptide. Dev Growth Differ 2010 Dec;52(9):799-806
OCTR-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Receptors, G-Protein-Coupled. Science. 2011 May 6;332(6030):729-32
GPR91 protein, human  0   *Receptors, G-Protein-Coupled. J Mol Biol 2001 Mar 30;307(3):799-813
RXFP2 protein, mouse  0   *Receptors, G-Protein-Coupled. Mamm Genome. 2010 Oct;21(9-10):442-9
CG30106 protein, Drosophila  0   *Drosophila Proteins *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun 2011 Jan 7;404(1):184-9
CG14593 protein, Drosophila  0   *Drosophila Proteins *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun 2011 Jan 7;404(1):184-9
GPR160 protein, human  0   *Receptors, G-Protein-Coupled. Cell Prolif 2011 Feb;44(1):59-66
GPR177 protein, zebrafish  0   *Zebrafish Proteins *Receptors, G-Protein-Coupled. Dev Dyn 2010 Sep;239(9):2426-34
Hcar2 protein, rat  0   *Receptors, Nicotinic *Receptors, G-Protein-Coupled. Bioorg Med Chem Lett 2010 Sep 15;20(18):5426-30
GPRC5A protein, mouse  0   *Receptors, G-Protein-Coupled. Cancer Res. 2010 Nov 1;70(21):8917-26
GPR124 protein, mouse  0   *Receptors, G-Protein-Coupled. Science 2010 Nov 12;330(6006):985-9
Gpr183 protein, rat  0   *Receptors, G-Protein-Coupled. Nature. 2010 Sep 23;467(7314):460-4
Gpr155 protein, mouse  0   *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun 2010 Jul 16;398(1):19-25
Gpr126 protein, mouse  0   *Receptors, G-Protein-Coupled. PLoS One 2010;5(2):e9198
GPER protein, zebrafish  0   *Zebrafish Proteins *Receptors, G-Protein-Coupled. Dev Biol 2010 Jun 15;342(2):194-206
GPR177 protein, rat  0   *Receptors, G-Protein-Coupled *Intracellular Signaling Peptides and Proteins. BMC Neurosci. 2010;11() (dup#18):33
GPR177 protein, human  0   *Receptors, G-Protein-Coupled *Intracellular Signaling Peptides and Proteins. BMC Neurosci. 2010;11() (dup#18):33
GPR125 protein, human  0   *Receptors, G-Protein-Coupled. Biol Reprod 2010 Feb;82(2):363-72
Lgr6 protein, mouse  0   *Receptors, G-Protein-Coupled. Science. 2010 Mar 12;327(5971):1385-9
Gpr149 protein, mouse  0   *Receptors, G-Protein-Coupled. Endocrinology 2010 Jan;151(1):358-68
GPR133 protein, human  0   *Receptors, G-Protein-Coupled. Hum Mol Genet 2009 Dec 1;18(23):4662-8
MrgprA3 protein, mouse  0   *Receptors, G-Protein-Coupled. Cell. 2009 Dec 24;139(7):1353-65
SRBC-66 protein, C elegans  0   *Caenorhabditis elegans Proteins *Receptors, G-Protein-Coupled. Science. 2009 Nov 13;326(5955):994-8
SRBC-64 protein, C elegans  0   *Caenorhabditis elegans Proteins *Receptors, G-Protein-Coupled. Science. 2009 Nov 13;326(5955):994-8
Gpr177 protein, mouse  0   *Receptors, G-Protein-Coupled *Intracellular Signaling Peptides and Proteins. Proc Natl Acad Sci U S A 2009 Nov 3;106(44):18598-603
Gpr183 protein, mouse  0   *Receptors, G-Protein-Coupled. Immunity 2009 Aug 21;31(2):259-69
gpr126 protein, Zebrafish  0   *Zebrafish Proteins *Receptors, G-Protein-Coupled. Science. 2009 Sep 11;325(5946):1353-4
TDAG8 protein, rat  0   *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun 2009 Aug 28;386(3):420-5
moody protein, Drosophila  0   *Drosophila Proteins *Receptors, G-Protein-Coupled. Cell 2005 Oct 7;123(1):145-56
sensory neuron-specific receptor 1, rat  0   *Receptors, G-Protein-Coupled. Pain. 2009 May;143(1-2):130-7
GPR30 protein, zebrafish  0   *Receptors, Estradiol *Receptors, G-Protein-Coupled. Gen Comp Endocrinol 2009 Mar;161(1):58-61
GPR172A protein, human  0   *Receptors, G-Protein-Coupled. Proc Natl Acad Sci U S A 2009 Apr 7;106(14):5848-53
ceramide 1-phosphate receptor, mouse  0   *Receptors, G-Protein-Coupled. Cell Signal 2009 Mar;21(3):405-12
GPR63 protein, human  0   *Receptors, G-Protein-Coupled. Clin Genet 2009 Feb;75(2):199-202
pyrokinin receptor, C elegans  0   *Caenorhabditis elegans Proteins *Receptors, G-Protein-Coupled. Biochem Biophys Res Commun 2009 Feb 13;379(3):760-4
GPR39 protein, rat  0   *Receptors, G-Protein-Coupled. Peptides 2008 Dec;29(12):2150-8
GPR17 protein, mouse  0   *Nerve Tissue Proteins *Receptors, G-Protein-Coupled. EMBO J 2006 Oct 4;25(19):4615-27
GTG2 protein, Arabidopsis  EC 3.6.1.-   *Arabidopsis Proteins *Receptors, G-Protein-Coupled GTP-Binding Proteins. Cell 2009 Jan 9;136(1):136-48
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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