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Receptor, Adenosine A1

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Definition: A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.      Other names Receptors, Adenosine A1; A1 Receptors, Adenosine; A1 Receptor, Adenosine; Adenosine A1 Receptor; Adenosine A1 Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-4-phenyl-8-pyrrolidin-1-ylmethylindeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Receptor, Adenosine A1 Receptor, Adenosine A2A Purinergic P1 Receptor Antagonists. Chem Res Toxicol 2011 Jul 18;24(7):1012-30
2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-indeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Receptor, Adenosine A1 Receptor, Adenosine A2A. J Med Chem 2010 Nov 25;53(22):8104-15
3,4',5-tri(glucose-3-O-succinyl)resveratrol  0   *Glucosides *Stilbenes Receptor, Adenosine A1/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Dec 1;19(23):6721-4
7-chloro-4-hydroxy-2-phenyl-1,8-naphthyridine  0   *Naphthyridines Receptor, Adenosine A1/antagonists & inhibitors. Blood 2009 Jul 30;114(5):1110-22
1-butyl-8-(3-noradamantyl)-3-(3-hydroxypropyl)xanthine  0   *Xanthines Receptor, Adenosine A1. Cell Biochem Funct 2008 Dec;26(8):833-43
5-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one  0   *Aminopyridines *Piperazines Receptor, Adenosine A1/antagonists & inhibitors Receptor, Adenosine A2A/antagonists & inhibitors. J Pharmacol Exp Ther 2007 Nov;323(2):708-19
selodenoson  0   Adenosine/*analogs & derivatives Receptor, Adenosine A1/agonists. Expert Rev Cardiovasc Ther 2007 Jul;5(4):707-14
N-cyclopentyl-2-(4-carbamoylpyrazol-1-yl)adenosine  0   *Pyrazoles Adenosine/*analogs & derivatives Receptor, Adenosine A1. Bioorg Med Chem Lett 2007 Jan 1;17(1):161-6
N-norbornyl-2-(4-carboxypyrazol-1-yl)adenosine  0   *Pyrazoles Adenosine/*analogs & derivatives Receptor, Adenosine A1. Bioorg Med Chem Lett 2007 Jan 1;17(1):161-6
7,8-dihydro-8-ethyl-2-(4-bicyclo(2.2.2)octan-1-ol)-4-propyl-1H-imidazo(2,1-i)purin-5(4H)-one  0   *Bicyclo Compounds *Purines Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2006 Nov 30;49(24):7132-9
9-butyl-2-(3-noradamantyl)-4,5-dihydro-6H,8H-pyrimido(1,2,3-cd)purine-8,10-dione  0   *Xanthines Adamantane/*analogs & derivatives Receptor, Adenosine A1/antagonists & inhibitors. ChemMedChem 2006 Aug;1(8):891-902
1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine  0   *Xanthines Adamantane/*analogs & derivatives Receptor, Adenosine A1/antagonists & inhibitors. ChemMedChem 2006 Aug;1(8):891-902
2-(6-((2-hydroxycyclopentyl)amino)purin-9-yl)-5-((2-fluorophenylthio)methyl)oxolane-3,4-diol  0   Adenosine/*analogs & derivatives Receptor, Adenosine A1/agonists. J Pharmacol Exp Ther 2006 May;317(2):676-84
8-cyclopentyl-2,6-diphenylpurine  0   *Purines Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2006 May 18;49(10):2861-7
isopropyl 1-(2-chloro-2-phenylethyl)-4-((2-(4-methoxyphenyl)ethyl)amino)-1H-pyrazolo(3,4-b)pyridine-5-carboxylate  0   *Pyrazoles *Pyridines Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2005 Nov 17;48(23):7172-85
methyl 1-(2-chloro-2-phenylethyl)-4-((2-(4-methoxyphenyl)ethyl)amino)-1H-pyrazolo(3,4-b)pyridine-5-carboxylate  0   *Pyrazoles *Pyridines Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2005 Nov 17;48(23):7172-85
BG 9928  0   *Xanthines Receptor, Adenosine A1. Curr Opin Investig Drugs 2005 Sep;6(9):962-8
3-(2-(4-aminophenyl)ethyl)-8-benzyl-7-(2-ethyl(2-hydroxyethyl)aminoethyl)-1-propyl-3,7-dihydropurine-2,6-dione  0   *Purines Receptor, Adenosine A1/antagonists & inhibitors. J Pharmacol Exp Ther 2005 Oct;315(1):329-36
2-amino-4-(3-trifluoromethylphenyl)-6-(2-hydroxyethylsulfanyl)pyridine-3,5-dicarbonitrile  0   *Aminopyridines Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):2045-53
2-amino-4-benzo(1,3)dioxol-5-yl-6-(2-hydroxyethylsulfanyl)pyridine-3,5-dicarbonitrile  0   *Aminopyridines *Dioxoles Receptor, Adenosine A1/agonists. J Med Chem 2005 Mar 24;48(6):2045-53
2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-3(2H)-pyridazinone  0   *Piperidines *Pyridazines Receptor, Adenosine A1/antagonists & inhibitors. J Pharmacol Sci. 2004 Sep;96(1):42-52
N-(4,6-diphenylpyrimidin-2-yl)butyramide  0   *Pyrimidinones Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2004 Dec 16;47(26):6529-40
2'-deoxyribose-N6-cyclopentyladenosine  0   *Deoxyadenosines Receptor, Adenosine A1/agonists. J Pharmacol Exp Ther 2004 Dec;311(3):1138-46
8-methylamino-N6-cyclopentyladenosine  0   Adenosine/*analogs & derivatives Receptor, Adenosine A1/agonists. J Pharmacol Exp Ther 2004 Dec;311(3):1138-46
8-cyclopentyl-3-(3-iodoprop-2-en-1-yl)-1-propylxanthine  0   *Xanthines Iodine Radioisotopes Receptor, Adenosine A1/antagonists & inhibitors. Nucl Med Biol 2003 Aug;30(6)661-8
1-butyl-8-(4-((4-nitrophenoxy)sulfonyl)phenyl)xanthine  0   *Sulfonic Acids *Xanthines Receptor, Adenosine A1/antagonists & inhibitors Receptors, Adenosine A2/antagonists & inhibitors. J Med Chem 2004 Feb 12;47(4):1031-43
1-propyl-8-(4-((4-nitrophenoxy)sulfonyl)phenyl)xanthine  0   *Sulfonic Acids *Xanthines Receptor, Adenosine A1/antagonists & inhibitors Receptors, Adenosine A2/antagonists & inhibitors. J Med Chem 2004 Feb 12;47(4):1031-43
5-N-methylimino-2-(3-methylphenyl)-3-phenyl-2H-(1,2,4)-thiadiazole  0   *Thiadiazoles Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2004 Jan 29;47(3):663-72

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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