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Taxoids

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Definition: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.  ROTAXANES is also available   
Examples Paclitaxel 		Other names Taxanes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
felotaxel  0   *Taxoids. Biomed Pharmacother. 2012 Mar;66(2):98-102.
2alpha,9alpha,10beta-triacetoxy-13alpha(beta-D-glucopyranosyloxy)taxa-4(20),11-dien-5alpha-ol  0   *Glucosides *Taxoids. Planta Med. 2011 Feb;77(3):281-3
5alpha,10beta,13beta-triacetoxy-2 alpha,7beta-dihydroxy-2(3-20) abeotaxa-4(20),11-dien-9-one  0   *Taxoids. Planta Med. 2011 Feb;77(3):281-3
5alpha,10beta,13alpha-triacetoxytax-11-ene-2alpha,7beta,9alpha,20-tetraol  0   *Taxoids. Planta Med. 2011 Feb;77(3):281-3
taxawallin I  0   *Taxoids. Fitoterapia. 2011 Mar;82(2):276-81
4-deacetylbaccatin III  0   *Taxoids. Nat Prod Commun. 2010 Nov;5(11):1727-8
cabazitaxel  0 4-acetoxy-13-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate  *Taxoids. Nat Rev Drug Discov 2010 Sep;9(9):677-8JEVTANA KIT
Syl611 compound  0   *Taxoids P-Glycoprotein/antagonists & inhibitors. Cancer Chemother Pharmacol 2010 Oct;66(5):851-9
4-deacetyl-1-dimethylsilyl-7-triethylsilylbaccatin III  0   *Alkaloids *Trimethylsilyl Compounds *Taxoids. J Org Chem. 2009 Mar 6;74(5):2186-8
7'-epidocetaxel  0   *Taxoids. Int J Clin Pharmacol Ther. 2010 Jul;48(7):483-4
2,10-diacetyl-5(Z)-cinnamoylphototaxicin II  0   *Taxoids Stereoisomerism. J Asian Nat Prod Res. 2009 Jun;11(6):534-8
5a-acetoxy-20-(benzoyloxy)-2a,4a,7b,9a,15-pentahydroxy-10- oxo-10,19-epoxy-11(15-1)abeo-tax-11(12)-ene  0   *Taxoids. Chem Biodivers 2009 Dec;6(12):2255-62
7,13-dideacetyl-2,9,10-debenzoyl-2-tigloyl-7beta,9alpha-p-hydroxylbenzylidenedioxy-taxchinin C  0   *Taxoids. Chem Pharm Bull (Tokyo). 2009 Sep;57(9):1008-10
7,13-dideacetyl-9,10-debenzoyl-7beta,9alpha-p-hydroxylbenzylidenedioxy-taxchinin C  0   *Taxoids. Chem Pharm Bull (Tokyo). 2009 Sep;57(9):1008-10
taxusecone  0   *Taxoids. Biosci Biotechnol Biochem 2009 Mar 23;73(3):756-8
1-deoxybaccatin VI  0   *Taxoids. Bioorg Med Chem Lett 2009 Feb 15;19(4):1148-51
neolaulimalide  0   *Taxoids. Org Lett 2008 Oct 16;10(20):4701-4
XRP6258  0   *Taxoids. Ann Oncol 2008 Sep;19(9):1547-52
larotaxel  0   *Taxoids. Ann Oncol 2008 Jul;19(7):1255-60
taxchinin A  0   *Taxoids. Bioorg Med Chem 2008 May 1;16(9):4860-71
5(12)-oxa-3(11)-cyclotaxane  0   *Taxoids. J Biol Chem 2008 Mar 7;283(10):6067-75
MST 997  0   *Taxoids. Clin Cancer Res 2006 Jun 1;12(11 Pt 1):3459-69
8,9-single-epoxy brevifolin  0   *Taxoids. Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(18):1529-32
2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyltaxa-4 (20) , 11-dien-5-ol  0   *Taxoids Alkaloids. Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(18):1510-3
1 beta-hydroxybaccatin I  0   *Taxoids Alkaloids. Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(18):1510-3
2alpha,5alpha,7beta,9alpha,13alpha-pentahydroxy-10beta-acetoxytaxa-4(20),11-diene  0   *Taxoids. Magn Reson Chem 2007 Jun;45(6):527-30
2alpha,7beta-diacetoxy-5alpha,10beta,13beta-trihydroxy-2(3-20)abeotaxa-4(20),11-dien-9-one  0   *Taxoids. Magn Reson Chem 2007 Jun;45(6):527-30
2-deacetoxytaxinine J  0   *Taxoids. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1579-83
taxuspine F  0   *Taxoids. Yao Xue Xue Bao. 2005 Aug;40(8):734-9
14-hydroxy-10-deacetyl-2-O-debenzoylbacatin III  0   *Taxoids. Chem Biodivers 2005 Oct;2(10):1316-9
2,20-O-diacetyltaxumairol N  0   *Taxoids. Chem Biodivers 2005 Oct;2(10):1316-9
1-acety-5,7,10-deacetyl-baccatin I  0   *Taxoids. J Asian Nat Prod Res. 2006 Apr-May;8(3):229-39
(2alpha,5alpha,7beta,9alpha,10beta,13alpha)-5,10,13,20-tetraacetoxytax-11-ene-2,7,9-triol  0   *Taxoids. Chem Biodivers. 2006 Oct;3(10):1153-61
(2alpha,5alpha,9alpha,10beta)-2,9,10-triacetoxy-5-((beta-D-glucopyranosyl)oxy)-3,11-cyclotax-11-en-13-one  0   *Taxoids. Chem Biodivers. 2006 Oct;3(10):1153-61
taxinine A  0   *Taxoids. Zhongguo Zhong Yao Za Zhi 2005 Aug;30(16):1260-3
taxchinin N  0   *Taxoids. J Nat Prod 2006 Dec;69(12):1813-5
11-desmethyllaulimalide  0   *Taxoids. Org Lett 2006 Mar 30;8(7):1507-10
2-debenzoyl-2-m-methoxybenozyl-7-triethylsilyl-13-oxo-14-hydroxybaccatin III 1,14-carbonate  0   *Trimethylsilyl Compounds *Taxoids. Bioorg Med Chem Lett 2006 Oct 15;16(20):5389-91
14-hydroxy-10-deacetylbaccatin III  0   *Taxoids. Bioorg Med Chem Lett 2006 Oct 15;16(20):5389-91
1-hydroxy- 2-deacetoxy-5-decinnamoyl-taxinine j  0   *Taxoids. Bioorg Med Chem Lett. 2006 May 1;16(9):2446-9
5alpha,13alpha-diacetoxy-10beta-cinnamoyloxy-4(20),11-taxadien-9alpha-ol  0   *Taxoids. Chem Pharm Bull (Tokyo) 2006 Mar;54(3):306-9
nonataxel  0   *Taxoids. Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4256-61
dibromo-10-deacetylcephalomannine  0   *Taxoids. J Med Chem 2006 Mar 23;49(6):1891-9
10-deacetyltaxinine  0   *Taxoids. Nat Prod Res. 2006 Jan;20(1):47-51
taxezopidine M  0   *Taxoids. J Nat Prod 2005 Jun;68(6):935-7
taxezopidine N  0   *Taxoids. J Nat Prod 2005 Jun;68(6):935-7
tasumatrol G  0   *Taxoids. J Nat Prod 2005 Jan;68(1):90-3
tasumatrol F  0   *Taxoids. J Nat Prod 2005 Jan;68(1):90-3
tasumatrol E  0   *Taxoids. J Nat Prod 2005 Jan;68(1):90-3
DF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Taxoids. J Clin Oncol 2005 Jan 20;23(3):494-501
9alpha-hydroxy-2alpha,10beta,13alpha-triacetoxy-5alpha-(3'-N,N-dimethylamino-3'-phenyl)-propionyloxytaxa-4(20),11-diene  0   *Taxoids. Phytochemistry. 2004 Dec;65(23):3097-106
2alpha-hydroxy-7beta,9alpha,10beta,13alpha-tetraacetoxy-5alpha-(2'-hydroxy-3'-N,N-dimethylamino-3'-phenyl)-propionyloxytaxa-4(20),11-diene  0   *Taxoids. Phytochemistry. 2004 Dec;65(23):3097-106
2alpha,9alpha-dihydroxy-10beta,13alpha-diacetoxy-5alpha-(3'-methylamino-3'-phenyl)-propionyloxytaxa-4(20),11-diene  0   *Taxoids. Phytochemistry. 2004 Dec;65(23):3097-106
2alpha,7beta,9alpha,10beta,13-pentaacetoxy-11beta-hydroxy-5alpha-(3'-N,N-dimethylamino-3'-phenyl)-propionyloxytaxa-4(20),12-diene  0   *Taxoids. Phytochemistry. 2004 Dec;65(23):3097-106
taxuyunnanine C  0   *Taxoids. Biotechnol Bioeng 2004 Jun 30;86(7):809-16
7-deoxy-10-deacetylbaccatin-III  0   *Taxoids. Biotechnol Appl Biochem 2004 Apr;39(Pt 2):209-14
6-alpha-hydroxy-7-deoxy-10-deacetylbaccatin-III  0   *Taxoids. Biotechnol Appl Biochem 2004 Apr;39(Pt 2):209-14
BAY59  0   *Taxoids. Oncology 2004;67(2):123-9
EDP protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Epirubicin Taxoids. Br J Cancer 2004 Jul 5;91(1);18-22
14beta-benzoyloxy-2-deacetylbaccatin VI  0   *Taxoids. J Nat Prod 2004 May;67(5);905-7
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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